1. the 7th letter of the Roman alphabet (同)g

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/24 14:38:05」(JST)

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English Journal

  • Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells via a GSK-3β-Dependent Mechanism.
  • Shyu HY1,2, Ko CJ1, Luo YC1, Lin HY1, Wu SR1, Lan SW1, Cheng TS1, Hu SH2, Lee MS1.
  • Journal of cellular biochemistry.J Cell Biochem.2016 Apr;117(4):881-93. doi: 10.1002/jcb.25372. Epub 2015 Sep 22.
  • Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous effects, including renal failure; however, the underlying mechanism is poorly understood. The process called epithelial phenotypi
  • PMID 26365534
  • The Neuroprotective Role of Insulin Against MPP(+) -Induced Parkinson's Disease in Differentiated SH-SY5Y Cells.
  • Ramalingam M1, Kim SJ1.
  • Journal of cellular biochemistry.J Cell Biochem.2016 Apr;117(4):917-26. doi: 10.1002/jcb.25376. Epub 2015 Sep 30.
  • Parkinson's disease (PD) is a common chronic neurodegenerative disorder associated with aging that primarily caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SN). Retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells (SH-SY5Y+RA) have been broadly util
  • PMID 26364587
  • TMPyP4-regulated cell proliferation and apoptosis through the Wnt/β-catenin signaling pathway in SW480 cells.
  • Zhang YQ1,2, Zhang YH1, Xie J1, Li MN1, Liu ZR1, Shen JY1, Shi SS3, Lan XY1, Wang S1, Cheng NL1.
  • Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Apr;36(2):167-72. doi: 10.3109/10799893.2015.1069846. Epub 2015 Sep 18.
  • BACKGROUND: The aim of this study was to investigate the potential effects of the 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP4) on the proliferation and apoptosis of SW480 cells and the underlying mechanisms by which TMPyP4 exerted its actions.METHODS: After treated with differ
  • PMID 26382555

Japanese Journal

  • Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage.
  • Maesako M,Uemura K,Kubota M,Hiyoshi K,Ando K,Kuzuya A,Kihara T,Asada M,Akiyama H,Kinoshita A
  • Neuroscience 177, 298-307, 2011-03-17
  • … Presenilin 1 (PS1), a causative molecule of familial Alzheimer's disease (AD), is known to be an unprimed substrate of glycogen synthase kinase 3 β (GSK3β) [Twomey and McCarthy (2006) FEBS Lett 580:4015-4020] and is phosphorylated at serine 353, 357 residues in its cytoplasmic loop region [Kirschenbaum et al. …
  • NAID 120002970866
  • 双極性障害の分子生物学の最近の進歩 (特集 双極性障害の新たな展開)
  • 高田 篤,加藤 忠史
  • 臨床精神医学 40(3), 291-298, 2011-03
  • NAID 40018750152

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glycogen synthase
  • グリコーゲンの合成酵素
inactive:glycogen synthase a
active  :glycogen synthase b
  • GSKによってリン酸化を受けて不活化する





glycogen synthase kinase, GSK
グリコーゲンシンターゼ glycogen synthase
glycogen synthase kinase 3 alpha
glycogen synthase kinase 3 beta




glycogen synthase kinase 3