glycogen synthase kinase

グリコーゲンシンターゼキナーゼ

WordNet

1. one form in which body fuel is stored; stored primarily in the liver and broken down into glucose when needed by the body (同)animal_starch
2. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
3. the basic unit of money in Papua New Guinea

PrepTutorEJDIC

1. グリコーゲン,糖原

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/02 21:19:39」(JST)

wiki en

[Wiki en表示]

Glycogen synthase kinase is an enzyme.

Types include:

• GSK1
• GSK2
• GSK-3
  • GSK3A
  • GSK3B

References

UpToDate Contents

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• 1. フォンヒッペル・リンダウ病の分子生物学および病因molecular biology and pathogenesis of von hippel lindau disease [show details]
  …cell polarity and results in cyst formation . Coordinate inactivation of VHL and glycogen synthase kinase 3 beta (GSK3B) is sufficient to induce loss of primary cilium and, in animal models of Vhlh and…
• 2. 特発性肺線維症の病因pathogenesis of idiopathic pulmonary fibrosis [show details]
  …following to lung injury . The Wnt proteins inhibit phosphorylation of beta-catenin by glycogen synthase kinase 3b (GSK3b), and prevent its translocation to nucleus and activation of the lymphoid enhancing…
• 3. 進行性核上性麻痺（PSP）：マネージメントおよび予後progressive supranuclear palsy psp management and prognosis [show details]
  …properties . One approach involves agents such as tideglusib, which inhibits a key enzyme (glycogen synthase kinase 3 beta) that plays a role in the hyperphosphorylation of tau . Another approach involves the…
• 4. 腎性尿崩症の治療treatment of nephrogenic diabetes insipidus [show details]
  …membrane and exposed to therapeutic concentrations of lithium (0.6 to 1.2 mmol/L) . Glycogen synthase kinase 3 (GSK-3 beta) is inhibited by lithium and is probably the common molecular target for the primary…
• 5. 腎性尿崩症の臨床症状および原因clinical manifestations and causes of nephrogenic diabetes insipidus [show details]
  …inhibits signaling pathways that involve glycogen synthase kinase type 3 beta (GSK3beta), resulting in dysfunction of the aquaporin-2 water channel . GSK3beta knock-out mice have a reduced response to…

English Journal

• Lithium inhibits palatal fusion and osteogenic differentiation in palatal shelves in vitro.

• Meng L1, Wang X2, Torensma R3, Von den Hoff JW4, Bian Z5.
• Archives of oral biology.Arch Oral Biol.2015 Mar;60(3):501-7. doi: 10.1016/j.archoralbio.2014.12.011. Epub 2014 Dec 18.
• OBJECTIVE: Glycogen synthase kinase-3β (Gsk-3β)/β-catenin signaling regulates development of the secondary palate. It has been unclear about the effects of Gsk-3β/β-catenin signaling on palatal fusion and osteogenic differentiation in palatal shelves.DESIGN: In this study, palatal shelves from
• PMID 25555252

• Intranodal Palisaded Myofibroblastoma: Another Mesenchymal Neoplasm With CTNNB1 (β-catenin Gene) Mutations: Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 18 Cases.

• Laskin WB1, Lasota JP, Fetsch JF, Felisiak-Golabek A, Wang ZF, Miettinen M.
• The American journal of surgical pathology.Am J Surg Pathol.2015 Feb;39(2):197-205. doi: 10.1097/PAS.0000000000000299.
• Intranodal palisaded myofibroblastoma is a benign, lymph node-based myofibroblastic tumor of unknown pathogenesis. We report the clinicopathologic, immunohistochemical, and molecular genetic features of this rare entity. The study cohort consisted of 14 men and 4 women ranging in age from 31 to 65 (
• PMID 25025452

• Looking beyond the role of glycogen synthase kinase-3 genetic expression on electroretinogram response: what about lithium?

• Lavoie J1, Hébert M2, Beaulieu JM3.
• Biological psychiatry.Biol Psychiatry.2015 Feb 1;77(3):e15-7. doi: 10.1016/j.biopsych.2014.07.024. Epub 2014 Aug 1.
• PMID 25193244

Japanese Journal

• L-theanine attenuates Isoflurane-induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice

• Chen Yong,Lian Fang,Lu Qiang,Peng Shengliang,Li Jiahao,Huang Song,Du Xiaohong
• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ, 2020
• <p>The neurodevelopmental toxicity of isoflurane has been proved by many studies, which makes it essential to explore the underline mechanisms and search for protective agents to attenuate its n …
• NAID 130007812029

• Differentiation-inducing factor-1は骨髄由来間葉系幹細胞の脂肪細胞への分化誘導を促進する

• 石兼 真,幾島 栄悟,瀧口 知浩,豊平 由美子,高橋 富美
• 日本薬理学会年会要旨集 93(0), 2-O-027, 2020
• … Further, the effects of DIF-1 on adipogenic and osteogenic differentiations were attenuated by treatment with glycogen synthase kinase-3 (GSK-3) inhibitor CHIR99021.</p><p><b>Conclusion:</b> …
• NAID 130007811526

• Adenosine N1-Oxide Exerts Anti-inflammatory Effects through the PI3K/Akt/GSK-3β Signaling Pathway and Promotes Osteogenic and Adipocyte Differentiation

• Ohashi Emiko,Kohno Keizo,Arai Norie,Harashima Akira,Ariyasu Toshio,Ushio Shimpei
• Biological & pharmaceutical bulletin 42(6), 968-676, 2019-06
• NAID 40021899852

Related Links

• GSK-3β - 脳科学辞典

Glycogen synthase kinase-3: functions in oncogenesis and development. Biochim. Biophys. Acta: 1992, 1114(2-3);147-62 [PubMed:1333807] [WorldCat.org] ↑ V Stambolic, J R Woodgett Mitogen inactivation of glycogen ↑ ...

• GSK-3阻害物質 | 酵素阻害物質 | フナコシ

GSK-3（Glycogen synthase kinase 3，グリコーゲン合成酵素 3）は，αとβの二種類のアイソフォームを持つセリン・スレオニンキナーゼで，グリコーゲン代謝の重要な因子として発見されました。また，細胞分裂，細胞増殖，細胞運動性 ...

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★リンクテーブル★

リンク元	「グリコーゲンシンターゼキナーゼ」
拡張検索	「glycogen synthase kinase 3」「glycogen synthase kinase 3beta」「glycogen synthase kinase 3 alpha」「glycogen synthase kinase 3 beta」
関連記事	「synthase」「kinase」「glycogen synthase」「glycogen」

「グリコーゲンシンターゼキナーゼ」

　　[★]

英

glycogen synthase kinase, GSK

関

グリコーゲンシンターゼ glycogen synthase

• GSK-3

glycogen synthase kinase 3 alpha

glycogen synthase kinase 3 beta

「glycogen synthase kinase 3」

　　[★]

グリコーゲン合成酵素キナーゼ3、グリコーゲンシンターゼキナーゼ3

関

GSK-3

同

GSK3＆NFAT activation

「glycogen synthase kinase 3beta」

　　[★]

グリコーゲン合成酵素キナーゼ3β

「glycogen synthase kinase 3 alpha」

　　[★]

• http://en.wikipedia.org/wiki/GSK3A

「glycogen synthase kinase 3 beta」

　　[★]

• Glycogen synthase kinase 3 beta

「synthase」

　　[★]

• n.

• (脱離酵素リアーゼの逆反応である合成方向の反応を指す) シンターゼ, 合成酵素, 付加酵素

関

lyase、synthetase、transferase

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「glycogen synthase」

　　[★] グリコーゲンシンターゼ

「glycogen」

　　[★] グリコーゲン