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1. 原発性両側副腎皮質大結節性過形成によるクッシング症候群cushings syndrome due to primary bilateral macronodular adrenal hyperplasia [show details]
…been reported in approximately 20 patients with BMAH . GIP receptors are not expressed in the normal adult or fetal zona fasciculata . GIP receptor overexpression in BMAH occurs from a single allele of …
2. 副腎皮質腫瘍の臨床症状および評価clinical presentation and evaluation of adrenocortical tumors [show details]
3. クッシング症候群の原因の特定establishing the cause of cushings syndrome [show details]
4. クッシング症候群の原因および病態生理causes and pathophysiology of cushings syndrome [show details]

English Journal

Hoizumi M, Sato T, Shimizu T, Kato S, Tsukiyama K, Narita T, Fujita H, Morii T, Sassa MH, Seino Y, Yamada Y.
Biochemical and biophysical research communications. 2019 Jun;513(4)974-982.
Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes glucose-depend
PMID 31003779

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands.

Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD.
Pharmacology & therapeutics. 2019 Jun;198()90-108.
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form. It is responsible for proteolytic cleavage o
PMID 30759373

GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men.

Skov-Jeppesen K, Svane MS, Martinussen C, Gabe MBN, Gasbjerg LS, Veedfald S, Bojsen-Møller KN, Madsbad S, Holst JJ, Rosenkilde MM, Hartmann B.
Bone. 2019 May;125()178-185.
Glucagon-like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) both inhibit bone resorption in humans but the underlying mechanisms are poorly understood. In vitro, GLP-2 activates the GIP-receptor (GIPR). Based on in vitro studies, we hypothesized that the antiresorptive eff
PMID 31100534

宮永之寛,上村陽一郎,上田昌宏
生物物理 58(5), 237-240, 2018
… We have identified a novel regulator of heterotrimeric G proteins, G protein interacting protein 1 (Gip1), that extends a dynamic range of <i>Dictyostelium</i> … Our studies revealed that the Gip1-dependent spatial regulation of G protein contributed to the dynamic range extension. … This differs from commonly known mechanisms including adaptation associated with the chemical modification of receptor. …
NAID 130007493735

Joo Erina,Harada Norio,Yamane Shunsuke,Fukushima Toru,Taura Daisuke,Iwasaki Kanako,Sankoda Akiko,Shibue Kimitaka,Harada Takanari,Suzuki Kazuyo,Hamasaki Akihiro,Inagaki Nobuya
Diabetes : a journal of the American Diabetes Association 11(1), 2-13, 2017-12
NAID 40021434294

Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes: A randomized, open-label, 2-arm parallel comparative, exploratory trial

Yabe Daisuke,Eto Takashi,Shiramoto Masanari,Irie Shin,Murotani Kenta,Seino Yusuke,Kuwata Hitoshi,Kurose Takeshi,Seino Susumu,Ahren Bo,Seino Yutaka
Diabetes Obesity and Metabolism 19(3), 442-447, 2017-03
… Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. …
NAID 120006382333