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1. T-B-NK+ SCID：病因および遺伝学 t b nk scid pathogenesis and genetics
2. DNAによる親子鑑定 parentage testing using dna
3. 次世代DNAシークエンシングの原理および臨床応用 principles and clinical applications of next generation dna sequencing
4. 小頭症に対する臨床遺伝学的アプローチ microcephaly a clinical genetics approach
5. サイトメガロウイルス感染の診断へのアプローチ approach to the diagnosis of cytomegalovirus infection

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells.

Hsu CC, Wang CH, Wu LC, Hsia CY, Chi CW, Yin PH, Chang CJ, Sung MT, Wei YH, Lu SH, Lee HC.SourceDepartment and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taiwan.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1830(10):4743-51. doi: 10.1016/j.bbagen.2013.06.004. Epub 2013 Jun 18.
BACKGROUND: Hypoxia-inducible factor-1α (HIF-1α) is an important transcription factor that modulates cellular responses to hypoxia and also plays critical roles in cancer progression. Recently, somatic mutations and decreased copy number of mitochondrial DNA (mtDNA) were detected in hepatocellular
PMID 23791554

Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17α-estradiol-induced apoptosis in human Jurkat T cells.

Han CR, Jun do Y, Kim YH, Lee JY, Kim YH.SourceLaboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1833(10):2220-32. doi: 10.1016/j.bbamcr.2013.05.016. Epub 2013 May 23.
In Jurkat T cell clone (JT/Neo), G2/M arrest, apoptotic sub-G1 peak, mitochondrial membrane potential (Δψm) loss, and TUNEL-positive DNA fragmentation were induced following exposure to 17α-estradiol (17α-E2), whereas none of these events (except for G2/M arrest) were induced in Jurkat cells ove
PMID 23707954

Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.

Jeon YH, Park YH, Kwon JH, Lee JH, Kim IY.SourceLaboratory of Cellular and Molecular Biochemistry, School of Life Sciences and Biotechnology, Korea University, 1, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, Republic of Korea.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1833(10):2135-42. doi: 10.1016/j.bbamcr.2013.05.005. Epub 2013 May 13.
14-3-3 reduces cell proliferation by inhibiting the activity of proteins involved in the signaling pathway that includes Akt kinase. Activation of Akt is enhanced by activating the mammalian target of rapamycin complex 2 (mTORC2). 14-3-3 is also a negative regulator of the mTORC2/Akt pathway, by int
PMID 23680186

Green Tea Extract Increases mRNA Expression of Enzymes Which Influence Epigenetic Marks in Newborn Female Offspring from Undernourished Pregnant Mother

Sun Yongkun,Mukai Yuuka,Tanaka Masato,Saito Takeshi,Sato Shin,Kurasaki Masaaki
PLoS ONE 8(8), e74559, 2013-08-29
… We found that green tea extract intake during lactation up-regulated the activation of AMP-activated protein kinase in young female offspring from protein-restricted dams and modulated the AMP-activated protein kinase pathway in the kidney. …
NAID 120005324559

A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.

Tomida Junya,Itaya Akiko,Shigechi Tomoko,Unno Junya,Uchida Emi,Ikura Masae,Masuda Yuji,Matsuda Shun,Adachi Jun,Kobayashi Masahiko,Meetei Amom Ruhikanta,Maehara Yoshihiko,Yamamoto Ken-Ichi,Kamiya Kenji,Matsuura Akira,Matsuda Tomonari,Ikura Tsuyoshi,Ishiai Masamichi,Takata Minoru
Nucleic acids research 41(14), 6930-6941, 2013-08-01
… When DNA replication is stalled at sites of DNA damage, a cascade of responses is activated in the cell to halt cell cycle progression and promote DNA repair. … A pathway initiated by the kinase Ataxia teleangiectasia and Rad3 related (ATR) and its partner ATR interacting protein (ATRIP) plays an important role in this response. …
NAID 120005323036

Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcome the cytarabine resistance in HL-60 leukemia cell line.

Nishi Rie,Yamauchi Takahiro,Negoro Eiju,Takemura Haruyuki,Ueda Takanori
Cancer Science 104, 502-507, 2013-04-00
… After being transported into leukemic cells, ara-C is phosphorylated, by several enzymes including deoxycytidine kinase (dCK), to ara-C triphosphate (ara-CTP), an active metabolite, and then incorporated into DNA, thereby inhibiting DNA synthesis. …
NAID 120005254373