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the 20th letter of the Roman alphabet (同)t
a brilliant and notable success

PrepTutorEJDIC

tritiumの化学記号
不意に一激 / 大当たり,大成功 / =coup d'etat
Colorado

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/26 05:58:00」(JST)

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[Wiki en表示]

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.^[1]^[2] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.^[3]^[4] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.^[5]

Interactions

COUP-TFI has been shown to interact with:

BCL11A,^[6]
BCL11B,^[6]
COPS2,^[7] and
ESR1.^[8]

References

^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (September 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (1 December 1986). "Identification of two factors required for transcription of the ovalbumin gene". Mol. Cell. Biol. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602.
^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (August 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258.
^ Tsai SY, Tsai MJ (April 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocr. Rev. 18 (2): 229–40. doi:10.1210/er.18.2.229. PMID 9101138.
^ ^a ^b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (1 May 1999). "Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 84131. PMID 10207062.
^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (July 2002). "Formation of an hERα–COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.

UpToDate Contents

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5. 再発性または転移性子宮頸癌のマネージメント management of recurrent or metastatic cervical cancer

English Journal

Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb.

Zhou X1, Liu F1, Tian M1, Xu Z1, Liang Q1, Wang C1, Li J1, Liu Z1, Tang K2, He M1, Yang Z3.
Development (Cambridge, England).Development.2015 May 1;142(9):1593-605. doi: 10.1242/dev.115279.
Neural stem cells (NSCs) persist in the adult mammalian subventricular zone (SVZ) of the lateral ventricle. Primary NSCs generate rapidly dividing intermediate progenitor cells, which in turn generate neuroblasts that migrate along the rostral migratory stream (RMS) to the olfactory bulb (OB). Here,
PMID 25922524

COUP-TFs and eye development.

Tang K1, Tsai SY2, Tsai MJ3.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Feb;1849(2):201-9. doi: 10.1016/j.bbagrm.2014.05.022. Epub 2014 May 27.
Recent studies reveal that COUP-TF genes are essential for neural development, cardiovascular development, energy metabolism and adipogenesis, as well as for organogenesis of multiple systems. In this review, we mainly describe the COUP-TF genes, molecular mechanisms of COUP-TF action, and their cru
PMID 24878540

The role of the orphan nuclear receptor COUP-TFII in tumorigenesis.

Xu M1, Qin J2, Tsai SY1, Tsai MJ1.
Acta pharmacologica Sinica.Acta Pharmacol Sin.2015 Jan;36(1):32-6. doi: 10.1038/aps.2014.86. Epub 2014 Oct 6.
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be
PMID 25283503

Japanese Journal

Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues

Demura Masashi,Wang Fen,Yoneda Takashi,Karashima Shigehiro,Mori Shunsuke,Oe Masashi,Kometani Mitsuhiro,Sawamura Toshitaka,Cheng Yuan,Maeda Yuji,Namiki Mikio,Ino Hidekazu,Fujino Noboru,Uchiyama Katsuharu,Tsubokawa Toshinari,Yamagishi Masakazu,Nakamura Yasuhiro,Ono Katsuhiko,Sasano Hironobu,Demura Yoshiki,Takeda Yoshiyu
Journal of Hypertension 29(6), 1185-1195, 2011-06
… Nuclear receptor families NR4A [nerve growth factor-induced clone B (NGFIB), Nur-related factor 1 (NURR1) and neuron-derived orphan receptor 1 (NOR1)] and NR2F [chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), COUP-TFII and NR2F6) activate, whereas NR5A1 [steroidogenic factor 1 (SF1)] represses CYP11B2 (aldosterone synthase) gene transcription. …
NAID 120003141563

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development

NAKA H
Nat Neurosci 11, 1014-1023, 2008
NAID 80019754546

Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions

PARK Joo-In,TSAI Sophia Y.,TSAI Ming-Jer
Keio journal of medicine 52(3), 174-181, 2003-09-01
… Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are one of the most characterized orphan receptors of the steroid/thyroid hormone receptor superfamily. … COUP-TFs play important roles in the regulation of organogenesis, neurogenesis, and cellular differentiation during embryonic development. …
NAID 10012735857

Related Pictures

★リンクテーブル★

リンク元	「COUP転写因子I」「COUP transcription factor I」
拡張検索	「COUP-TFII」
関連記事	「TF」「T」「CO」

「COUP転写因子I」

Nuclear receptor subfamily 2, group F, member 1
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2EBL
Identifiers
Symbols	NR2F1 ; BBOAS; BBSOAS; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F2; SVP44; TCFCOUP1; TFCOUP1
External IDs	OMIM: 132890 MGI: 1352451 HomoloGene: 21158 IUPHAR: 617 GeneCards: NR2F1 Gene
Gene ontology
Molecular function	• sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • transcription coactivator activity; • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; • protein binding; • zinc ion binding; • sequence-specific DNA binding; • retinoic acid-responsive element binding;
Cellular component	• nucleus; • nucleoplasm;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • neuron migration; • transcription initiation from RNA polymerase II promoter; • signal transduction; • gene expression; • negative regulation of neuron projection development; • cerebral cortex regionalization; • intracellular receptor signaling pathway; • steroid hormone mediated signaling pathway; • positive regulation of transcription from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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