English Journal

Prospective randomized study of cefepime, panipenem, or meropenem monotherapy for patients with hematological disorders and febrile neutropenia.

Nakagawa Y, Suzuki K, Ohta K, Hino M, Ohyashiki K, Kanamaru A, Tamura K, Urabe A, Masaoka T; Japan Febrile Neutropenia Study Group.SourceDepartment of Hematology and Chemotherapy, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan. y-nak@white.plala.or.jp
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2013 Feb;19(1):103-11. doi: 10.1007/s10156-012-0466-8. Epub 2012 Sep 5.
The aim of this study was to evaluate the usefulness of carbapenems as initial treatment for febrile neutropenia (FN), and in patients unresponsive to this initial therapy, to evaluate the efficacy of subsequent treatment with aminoglycosides (AGs) or ciprofloxacin (CPFX). FN patients were randomize
PMID 22948387

Randomized controlled trial comparing ciprofloxacin and cefepime in febrile neutropenic patients with hematological malignancies.

Yasuda T, Suzuki R, Ishikawa Y, Terakura S, Inamoto Y, Yanada M, Nagai H, Ozawa Y, Ozeki K, Atsuta Y, Emi N, Naoe T.SourceDepartment of Hematology and Oncology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.Int J Infect Dis.2013 Jan 10. pii: S1201-9712(12)01327-6. doi: 10.1016/j.ijid.2012.12.005. [Epub ahead of print]
BACKGROUND: Ciprofloxacin (CPFX) is a potential alternative in patients with febrile neutropenia (FN) because of its activity against Gram-negative organisms. We conducted a non-inferiority, open-label, randomized controlled trial comparing intravenous CPFX and cefepime (CFPM) for FN patients with h
PMID 23317527

Japanese Journal

多剤耐性緑膿菌に対する抗菌性の基礎的検討

高岡洋五
医学検査 : 日本臨床衛生検査技師会誌 = The Japanese journal of medical technology 60(3), 197-201, 2011-03-25
NAID 10030458262

カルバペネム系抗菌薬の使用と緑膿菌の薬剤耐性

栃倉尚広,鏑木盛雄,山舘周恒,本石寛行,林国樹
日本環境感染学会誌 = Japanese journal of environmental infections 24(3), 195-201, 2009-05-25
… た緑膿菌38株について，カルバペネム5抗菌薬のMICを測定した．①カルバペネム使用量は2007年7〜12月以降，著明な増加がみられた．②2007年1〜6月以前では，感性率の経時変化は乏しくAMK, GM, CPFX, LVFX, PIPC, CFPMでは90%以上が感性であり，IPM, MEPMにおいても感性率80%以上を維持していた．これに対し2008年では90%以上の感性率を示した抗菌薬はAMK, GM, PIPCの3抗菌薬に減少し，使用量増加と感性菌減少との関連が示唆された …
NAID 10024804412

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