登上線維 CF climbing fiber
WordNet
- tell a relatively insignificant lie; "Fibbing is not acceptable, even if you dont call it lying"
- a trivial lie; "he told a fib about eating his spinach"; "how can I stop my child from telling stories?" (同)story, tale, tarradiddle, taradiddle
PrepTutorEJDIC
- (ささいな,罪のない)うそ / 軽いうそをつく
- =fiber
- 登る,はい登る / 登ること,登山
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/26 08:39:55」(JST)
[Wiki en表示]
| Climbing fiber |
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Microcircuitry of the cerebellum. Excitatory synapses are denoted by (+) and inhibitory synapses by (-). Climbing fiber is shown originating from the inferior olive (green).
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| Details |
| Location |
Inferior Olive and Cerebellum |
| Morphology |
Unique projection neuron (see text) |
| Function |
Unique excitatory function (see text) |
| Neurotransmitter |
Aspartate |
| Presynaptic connections |
Inferior olive |
| Postsynaptic connections |
Purkinje cells |
| Anatomical terminology
[edit on Wikidata]
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Climbing fibers are the name given to a series of neuronal projections from the inferior olivary nucleus located in the medulla oblongata.[1][2]
These axons pass through the pons and enter the cerebellum via the inferior cerebellar peduncle where they form synapses with the deep cerebellar nuclei and Purkinje cells. Each climbing fiber will form synapses with 1-10 Purkinje cells.
Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell.
These fibers provide very powerful, excitatory input to the cerebellum which results in the generation of complex spike excitatory postsynaptic potential (EPSP) in Purkinje cells.[1] In this way climbing fibers (CFs) perform a central role in motor behaviors.[3]
The climbing fibers carry information from various sources such as the spinal cord, vestibular system, red nucleus, superior colliculus, reticular formation and sensory and motor cortices. Climbing fiber activation is thought to serve as a motor error signal sent to the cerebellum, and is an important signal for motor timing. In addition to the control and coordination of movements,[4] the climbing fiber afferent system contributes to sensory processing and cognitive tasks likely by encoding the timing of sensory input independently of attention or awareness .[5][6] [7]
In the central nervous system, these fibers are able to undergo remarkable regenerative modifications in response to injuries, being able to generate new branches by sprouting to innervate surrounding Purkinje cells if these lose their CF innervation.[8] This kind of injury-induced sprouting has been shown to need the growth associated protein GAP-43.[9][10][11]
See also
- Axon terminals
- Parallel fiber
References
- ^ a b Harting, John K.; Helmrick, Kevin J. (1996,1997). "Cerebellum - Circuitry - Climbing Fibers". Retrieved 2008-12-25.
- ^ Bear, Mark F.; Michael A. Paradiso; Barry W. Connors (2006). Neuroscience: Exploring the Brain (Digitised online by Google Books). Lippincott Williams & Wilkins. p. 773. ISBN 978-0-7817-6003-4. Retrieved 2008-12-25. Image of Parallel fiber
- ^ McKay, Bruce E.; Engbers, Jordan D. T., W. Hamish Mehaffey, Grant R. J. Gordon, Michael L. Molineux, Jaideep S. Bains, and Ray W. Turner; Mehaffey, WH; Gordon, GR; Molineux, ML; Bains, JS; Turner, RW (January 31, 2007). "Climbing Fiber Discharge Regulates Cerebellar Functions by Controlling the Intrinsic Characteristics of Purkinje Cell Output" (PDF). Journal of neurophysiology (J Neurophysiol) 97 (4): 2590–604. doi:10.1152/jn.00627.2006. PMID 17267759. Retrieved 2008-12-25.
- ^ "Medical Neurosciences".
- ^ Xu D, Liu T, Ashe J, Bushara KO. Role of the olivo-cerebellar system in timing" J Neurosci 2006; 26: 5990-5.
- ^ Liu T, Xu D, Ashe J, Bushara K. Specificity of inferior olive response to stimulus timing. J Neurophysiol 2008; 100: 1557-61.
- ^ Wu X, Ashe J, Bushara KO. Role of olivocerebellar system in timing without awareness. Proc Natl Acad Sci U S A 2011.
- ^ Carulli D, Buffo A, Strata P; Buffo; Strata (April 2004). "Reparative mechanisms in the cerebellar cortex". Prog Neurobiol 72 (6): 373–98. doi:10.1016/j.pneurobio.2004.03.007. PMID 15177783.
- ^ Grasselli G, Mandolesi G, Strata P, Cesare P; Mandolesi; Strata; Cesare (June 2011). "Impaired Sprouting and Axonal Atrophy in Cerebellar Climbing Fibres following In Vivo Silencing of the Growth-Associated Protein GAP-43". PLoS ONE 6 (6): e20791. doi:10.1371/journal.pone.0020791. PMC 3112224. PMID 21695168.
- ^ Grasselli G, Strata P; Strata (February 2013). "Structural plasticity of climbing fibers and the growth-associated protein GAP-43". Front. Neural Circuits 7 (25): 25. doi:10.3389/fncir.2013.00025. PMC 3578352. PMID 23441024.
- ^ Mascaro, Allegra; Cesare, P.; Sacconi, L.; Grasselli, G.; Mandolesi, G.; Maco, G.; Knott, G.W.; Huang, L.; De Paola, V.; et al. (2013). "In vivo single branch axotomyinduces GAP-43-dependent sprouting and synaptic remodeling in cerebellarcortex". Proc Natl Acad Sci U S A 110 (26): 10824–10829. doi:10.1073/pnas.1219256110. PMID 23754371.
External links
- Climbing Fiber Discharge Regulates Cerebellar Functions by Controlling the intrinsic Characteristics of Purkinje Cell Output
- Spatiotemporal Tuning of Optic Flow Inputs to the Vestibulocerebellum in Pigeons: Differences Between Mossy and Climbing Fiber Pathways
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Anatomy of the cerebellum
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| Surface |
| Lobes |
- Anterior lobe
- Posterior lobe
- Flocculonodular lobe
- Primary fissure
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| Medial/lateral |
- Vermis: anterior
- Central lobule
- Culmen
- Lingula
- posterior
- Vallecula of cerebellum
- Hemisphere: anterior
- posterior
- Biventer lobule
- Cerebellar tonsil
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| Grey matter |
| Deep cerebellar nuclei |
- Dentate
- interposed
- Fastigial
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| Cerebellar cortex |
- Molecular layer
- Stellate cell
- Basket cell
- Purkinje cell layer
- Purkinje cell
- Bergmann glia cell = Golgi epithelial cell
- Granule cell layer
- Golgi cell
- Granule cell
- Unipolar brush cell
- Fibers: Mossy fibers
- Climbing fiber
- Parallel fiber
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| White matter |
| Internal |
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| Peduncles |
- Inferior (medulla): Dorsal spinocerebellar tract
- Olivocerebellar tract
- Cuneocerebellar tract
- Juxtarestiform body (Vestibulocerebellar tract)
- Trigeminocerebellar fibers
- Middle (pons): Pontocerebellar fibers
- Superior (midbrain): Ventral spinocerebellar tract
- Dentatothalamic tract
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Index of the central nervous system
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| Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
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| Disease |
- Addiction
- Cerebral palsy
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
- Tests
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| Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- dependence
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
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UpToDate Contents
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English Journal
- Fear conditioning-related changes in cerebellar Purkinje cell activities in goldfish.
- Yoshida M, Kondo H.SourceGraduate School of Biosphere Science, Hiroshima University, Higashihiroshima, 739-8528, Japan. yosidam@hiroshima-u.ac.jp.
- Behavioral and brain functions : BBF.Behav Brain Funct.2012 Oct 31;8:52. doi: 10.1186/1744-9081-8-52.
- ABSTRACT:BACKGROUND: Fear conditioning-induced changes in cerebellar Purkinje cell responses to a conditioned stimulus have been reported in rabbits. It has been suggested that synaptic long-term potentiation and the resulting increases in firing rates of Purkinje cells are related to the acquisitio
- PMID 23114007
- Conserved cellular distribution of the glutamate receptors GluA2/3, mGlu1a and mGlu2/3 in isolated cultures of rat cerebellum.
- Ramos-Uriarte A, Elezgarai I, Grandes P, Gomez-Urquijo SM.SourceDepartment of Neurosciences, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, E-48940 Leioa, Spain.
- Journal of chemical neuroanatomy.J Chem Neuroanat.2012 Oct;45(1-2):26-35. doi: 10.1016/j.jchemneu.2012.07.001. Epub 2012 Aug 10.
- To what extent the intrinsic glutamatergic system of the cerebellum is able to keep normal features in the absence of mossy and climbing fibres, is at present not known. To answer this question, immunocytochemistry for light and high resolution electron microscopy was used to reveal the cellular and
- PMID 22902587
- Functional integration of calcium regulatory mechanisms at Purkinje neuron synapses.
- Empson RM, Knöpfel T.SourceDepartment of Physiology, Brain Health and Repair Research Centre, University of Otago School of Medical Sciences, Dunedin, New Zealand.
- Cerebellum (London, England).Cerebellum.2012 Sep;11(3):640-50. doi: 10.1007/s12311-010-0185-6.
- Cerebellar Purkinje neurons receive synaptic inputs from three different sources: the excitatory parallel fibre and climbing fibre synapses as well as the inhibitory synapses from molecular layer stellate and basket cells. These three synaptic systems use distinct mechanisms in order to generate Ca(
- PMID 20596808
Japanese Journal
- 登上線維入力が小脳プルキンエ細胞の活動に与える影響(脳・ヒューマンモデリング1, 脳・ヒューマンモデリング, 一般)
- Correlation between multiple climbing fibre regression and parallel fibre response development in the postnatal mouse cerebellum
- A novel morphological technique to investigate a single climbing fibre synaptogenesis with a Purkinje cell in the developing mouse cerebellum : Dil injection into the inferior cerebellar peduncle
Related Links
- The climbing fibers carry information from various sources such as the spinal cord, vestibular system, red nucleus, superior colliculus, reticular formation and sensory and motor cortices. Climbing fiber activation is thought to serve as a motor ...
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線維
- 関
- fiber、filament