WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
informal term for information; "give me the gen on your new line of computers"

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1. 毛細血管拡張性運動失調症 ataxia telangiectasia
2. 遺伝性乳癌・卵巣癌症候群の特徴 characteristics of hereditary breast and ovarian cancer syndromes
3. マントル細胞リンパ腫の病理学 pathobiology of mantle cell lymphoma
4. 膵外分泌癌の分子学的病因 molecular pathogenesis of exocrine pancreatic cancer
5. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency

Class Switch Recombination Process in Ataxia Telangiectasia Patients with Elevated Serum Levels of IgM.

Mohammadinejad P1, Abolhassani H, Aghamohammadi A, Pourhamdi S, Ghosh S, Sadeghi B, Nasiri Kalmarzi R, Durandy A, Borkhardt A.
Journal of immunoassay & immunochemistry.J Immunoassay Immunochem.2015;36(1):16-26. doi: 10.1080/15321819.2014.891525.
Ataxia telangiectasia (AT) is a rare primary immunodeficiency disorder with various clinical manifestations. Increased serum levels of IgM and recurrent infections, mainly sinopulmonary infections, can be the presenting feature in a number of AT patients and may be initially misdiagnosed as hyper-Ig
PMID 24568663

A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway.

Sarma P1, Ramaiah MJ2, Kamal A3, Bhadra U4, Bhadra MP2.
Cancer biology & therapy.Cancer Biol Ther.2014 Oct 1;15(10):1320-32. doi: 10.4161/cbt.29705. Epub 2014 Jul 10.
DNA damage response (DDR) that includes cell cycle check points, DNA repair, apoptosis, and senescence is intimately linked with cancer. It shields an organism against cancer development when genomic integrity fails. DNA repair pathways protect the cells from tumor progression caused as a result of
PMID 25010292

The antioxidant butylated hydroxyanisole potentiates the toxic effects of propylparaben in cultured mammalian cells.

Martín JM1, Freire PF1, Daimiel L2, Martínez-Botas J2, Sánchez CM2, Lasunción MÁ2, Peropadre A1, Hazen MJ3.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2014 Oct;72:195-203. doi: 10.1016/j.fct.2014.07.031. Epub 2014 Jul 30.
Butylated hydroxyanisole and propylparaben are phenolic preservatives commonly used in food, pharmaceutical and personal care products. Both chemicals have been subjected to extensive toxicological studies, due to the growing concern regarding their possible impacts on environmental and human health
PMID 25086368

Shamma Awad,Suzuki Misa,Hayashi Naoyuki,Kobayashi Masahiko,Sasaki Nobunari,Nishiuchi Takumi,Doki Yuichiro,Okamoto Takahiro,Kohno Susumu,Muranaka Hayato,Kitajima Shunsuke,Yamamoto Ken-ichi,Takahashi Chiaki
Molecular biology of the cell 33(16), 3113-3124, 2013-08
… The retinoblastoma tumor suppressor gene (RB) product has been implicated in epigenetic control of gene expression owing to its ability to physically bind to many chromatin modifiers. … Here we report that the genetic interaction of Rb and ATM regulates DNMT1 protein stability and hence controls the DNA methylation status in the promoters of at least the Ink4a, Shc2, FoxO6, and Noggin genes. …
NAID 120005312327

Role of NBS1 in DNA damage response and its relationship with cancer development

Saito Yuichiro,Fujimoto Hiroko,Kobayashi Junya
Translational Cancer Research 2(3), 178-189, 2013-06
… NBS1, the product of the causative gene in NBS, contains several protein-interaction motifs in the N-terminus and C-terminus. … The N-terminal FHA/BRCT domains interact with MDC1, γ-H2AX, TopBP1, and WRN, and the C-terminal motifs are indispensable for binding MRE11, ataxia telangiectasia mutated (ATM), RAD18, and RNF20. …
NAID 120005300469

Global Identification of Genes Related to Nutrient Deficiency in Intervertebral Disc Cells in an Experimental Nutrient Deprivation Model

Sudo Hideki,Yamada Katsuhisa,Iwasaki Koji,Higashi Hideaki,Ito Manabu,Minami Akio,Iwasaki Norimasa
PLOS ONE 8(3), e58806, 2013-03-08
… Global gene expression was profiled by microarray analysis. … Serum starvation of NP cells significantly affected the expression of several genes involved in DNA damage checkpoints of the cell cycle, including Atm, Brca1, Cdc25, Gadd45, Hus1, Ppm1D, Rad 9, Tp53, and Cyclin D1. …
NAID 120005295654