WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

answer / ampere
antipersonnel / (またA.P.)Associated Press

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 尿素サイクル障害：管理 urea cycle disorders management
2. 幼児期および小児期早期の一過性高リン血症 transient hyperphosphatasemia of infancy and early childhood
3. 尿素サイクル障害：臨床的特徴および診断 urea cycle disorders clinical features and diagnosis
4. 正常な副腎皮質性第二次性徴 normal adrenarche
5. 結核の微生物学および病因 microbiology and pathogenesis of tuberculosis

English Journal

Involvement of plasma membrane peroxidases and oxylipin pathway in the recovery from phytoplasma disease in apple (Malus domestica).

Patui S, Bertolini A, Clincon L, Ermacora P, Braidot E, Vianello A, Zancani M.SourceDepartment of Agricultural and Environmental Science, University of Udine, Udine 33100, Italy.
Physiologia plantarum.Physiol Plant.2013 Jun;148(2):200-13. doi: 10.1111/j.1399-3054.2012.01708.x. Epub 2012 Nov 1.
Apple trees (Malus domestica Borkh.) may be affected by apple proliferation (AP), caused by 'Candidatus Phytoplasma mali'. Some plants can spontaneously recover from the disease, which implies the disappearance of symptoms through a phenomenon known as recovery. In this article it is shown that NAD(
PMID 23039876

Alzheimer's Disease Associated Polymorphisms in Human OGG1 Alter Catalytic Activity and Sensitize Cells to DNA Damage.

Jacob KD, Hooten NN, Tadokoro T, Lohani A, Barnes J, Evans MK.SourceLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224-6825, USA.
Free radical biology & medicine.Free Radic Biol Med.2013 May 14. pii: S0891-5849(13)00220-7. doi: 10.1016/j.freeradbiomed.2013.05.010. [Epub ahead of print]
Brain tissues from Alzheimer's Disease (AD) patients show increased levels of oxidative DNA damage and 7,8-dihydro-8-oxoguanine (8-oxoG) accumulation. In humans, the base excision repair protein 8-oxoguanine-DNA glycosylase (OGG1) is the major enzyme that recognizes and excises the mutagenic DNA bas
PMID 23684897

A Covalent Protein-DNA 5'-Product Adduct is Generated Following AP Lyase Activity of Human AlkB Homolog 1 (ALKBH1).

Müller TA, Andrzejak MM, Hausinger RP.AbstractALKBH1 is a mammalian AlkB homolog that possesses abasic site (AP) lyase activity. The AP lyase reaction is catalyzed by imine formation with an active site Lys, and a covalent intermediate can be trapped in the presence of NaBH4. Surprisingly, ALKBH1 also forms a stable protein-DNA adduct in the absence of a reducing agent. Experiments with different substrates demonstrated that the protein covalently binds to the 5' DNA product; i.e., the fragment containing an α,β-unsaturated aldehyde. The amino terminal domain of ALKBH1 was identified as the main site of linkage with DNA. By contrast, mutagenesis studies suggest that the primary catalytic residue forming the imine linkage is Lys133, with Lys154 and other Lys residues in this region serving in opportunistic roles. These findings confirm the classification of ALKBH1 as an AP lyase, identify the primary and a secondary Lys involved in the lyase reaction, and demonstrate the protein forms a covalent adduct with the 5' DNA product. We propose two plausible chemical mechanisms to account for the covalent attachment.
The Biochemical journal.Biochem J.2013 Apr 12. [Epub ahead of print]
ALKBH1 is a mammalian AlkB homolog that possesses abasic site (AP) lyase activity. The AP lyase reaction is catalyzed by imine formation with an active site Lys, and a covalent intermediate can be trapped in the presence of NaBH4. Surprisingly, ALKBH1 also forms a stable protein-DNA adduct in the ab
PMID 23577621

Japanese Journal

Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage

KANAMITSU Kyoichiro,IKEDA Shogo
Genes & genetic systems 86(2), 83-91, 2011-04-25
… Here, we studied the roles of NER components in repair of 3-meA and BER intermediates such as the AP site and single strand breaks. … pombe, AP lyase activity of Nth1p mainly incises the AP site to generate a 3′-blocked end, which is in turn converted to 3′-OH by Apn2p. … Deletion of rad16 or rhp26 in the nth1Δ strain greatly enhanced MMS sensitivity, suggesting that the AP site could also be corrected by TCR. …
NAID 10029516389

Radiation Resistance in Glioma Cells Determined by DNA Damage Repair Activity of Ape1/Ref-1

NAIDU Mamta D.,MASON James M.,PICA Raymond V.,FUNG Hua,PENA Louis A.
Journal of radiation research 51(4), 393-404, 2010-07-16
… Human apurinic endonuclease 1 (Ape1, Ref-1, APEX, HAP1, AP endo) is a multifunctional protein involved in base excision repair of DNA and a redox-dependent transcriptional co-activator. …
NAID 10026563796