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a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes

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Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction.

Aonuma T1, Takehara N2, Maruyama K1, Kabara M3, Matsuki M1, Yamauchi A1, Kawabe JI3, Hasebe N1.
Stem cells translational medicine.Stem Cells Transl Med.2016 Jun 22. pii: sctm.2015-0281. [Epub ahead of print]
: Overcoming the insufficient survival of cell grafts is an essential objective in cell-based therapy. Apurinic/apyrimidinic endonuclease/redox factor 1 (APE1) promotes cell survival and may enhance the therapeutic effect of engrafted cells. The aim of this study is to determine whether APE1 overexp
PMID 27334489

Base excision DNA repair in the embryonic development of the sea urchin, Strongylocentrotus intermedius.

Torgasheva NA1, Menzorova NI2, Sibirtsev YT2, Rasskazov VA2, Zharkov DO1, Nevinsky GA1.
Molecular bioSystems.Mol Biosyst.2016 Jun 21;12(7):2247-56. doi: 10.1039/c5mb00906e.
In actively proliferating cells, such as the cells of the developing embryo, DNA repair is crucial for preventing the accumulation of mutations and synchronizing cell division. Sea urchin embryo growth was analyzed and extracts were prepared. The relative activity of DNA polymerase, apurinic/apyrimi
PMID 27158700

APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.

Stetler RA1, Gao Y2, Leak RK3, Weng Z4, Shi Y4, Zhang L4, Pu H5, Zhang F1, Hu X1, Hassan S4, Ferguson C6, Homanics GE6, Cao G1, Bennett MV7, Chen J8.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 Jun 21;113(25):E3558-67. doi: 10.1073/pnas.1606226113. Epub 2016 Jun 6.
A major hallmark of oxidative DNA damage after stroke is the induction of apurinic/apyrimidinic (AP) sites and strand breaks. To mitigate cell loss after oxidative DNA damage, ischemic cells rapidly engage the base excision-repair proteins, such as the AP site-repairing enzyme AP endonuclease-1 (APE
PMID 27274063

Formation of the Nitrative DNA Lesion 8-Nitroguanine is Associated with Asbestos Contents in Human Lung Tissues: A Pilot Study

Hiraku Yusuke,Sakai Kiyoshi,Shibata Eiji,Kamijima Michihiro,Hisanaga Naomi,Ma Ning,Kawanishi Shosuke,Murata Mariko
Journal of Occupational Health 56(3), 186-196, 2014
… Results: In subjects without mesothelioma, staining intensities of 8-nitroG and apurinic/apyrimidinic endonuclease 1 (APE1) were significantly correlated with total asbestos and amphibole contents (p<0.05), but not with chrysotile content. …
NAID 130004447649

Apurinic/apyrimidinic endonuclease-1 (APE-1) is overexpressed via the activation of NF-κB-p65 in MCP-1-positive esophageal squamous cell carcinoma tissue

Song Junmin,Futagami Seiji,Nagoya Hiroyuki,Kawagoe Tetsuro,Yamawaki Hiroshi,Kodaka Yasuhiro,Tatsuguchi Atsushi,Gudis Katya,Wakabayashi Taiga,Yonezawa Masaoki,Shimpuku Mayumi,Watarai Yasuhiko,Iwakiri Katsuhiko,Hoshihara Yoshio,Makino Hiroshi,Miyashita Masao,Tsuchiya Shinichi,Li Yan,E. Crowe Sheila,Sakamoto Choitsu
Journal of Clinical Biochemistry and Nutrition 52(2), 112-119, 2013
… Apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzyme responsible for DNA base excision repair (BER), has been linked to cancer chemoradiosensitivity. …
NAID 130004466710

Radiation Resistance in Glioma Cells Determined by DNA Damage Repair Activity of Ape1/Ref-1

Naidu Mamta D.,Mason James M.,Pica Raymond V. [他],FUNG Hua,PENA Louis A.
Journal of radiation research 51(4), 393-404, 2010-07-16
… Human apurinic endonuclease 1 (Ape1, Ref-1, APEX, HAP1, AP endo) is a multifunctional protein involved in base excision repair of DNA and a redox-dependent transcriptional co-activator. …
NAID 10026563796