3-hydroxyacyl-CoA dehydrogenase

3-ヒドロキシアシルCoA脱水素酵素、3-ヒドロキシアシルCoAデヒドロゲナーゼ

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

1. carbonの化学記号
2. cobaltの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/08 18:27:20」(JST)

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See also: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase

3-hydroxyacyl-CoA dehydrogenase
Identifiers
EC number	1.1.1.35
CAS number	9028-40-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Hydroxyacyl-Coenzyme A dehydrogenase
PDB rendering based on 3had.
Identifiers
Symbol	HADH
Alt. symbols	HADHSC
Entrez	3033
HUGO	4799
OMIM	601609
RefSeq	NM_005327
UniProt	Q16836
Other data
EC number	1.1.1.35
Locus	Chr. 4 q22-q26

In enzymology, a 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxyacyl-CoA + NAD⁺ 3-oxoacyl-CoA + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-3-hydroxyacyl-CoA and NAD⁺, whereas its 3 products are 3-oxoacyl-CoA, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor.

Isozymes

In humans, the following genes encode proteins with 3-hydroxyacyl-CoA dehydrogenase activity:

• HADH – Hydroxyacyl-Coenzyme A dehydrogenase
• HSD17B10 – 3-Hydroxyacyl-CoA dehydrogenase type-2
• EHHADH – Peroxisomal bifunctional enzyme
• HSD17B4 – Peroxisomal multifunctional enzyme type 2

Function

3-Hydroxyacyl CoA dehydrogenase is classified as an oxidoreductase.It is involved in fatty acid metabolic processes. Specifically it catalyzes the third step of beta oxidation; the oxidation of L-3-hydroxyacyl CoA by NAD⁺. The reaction converts the hydroxyl group into a keto group.

The end product is 3-ketoacyl CoA.

Metabolic pathways

This enzyme participates in 8 metabolic pathways:

• fatty acid elongation in mitochondria
• fatty acid metabolism
• valine, leucine and isoleucine degradation
• lysine degradation
• tryptophan metabolism
• benzoate degradation via coa ligation
• butanoate metabolism
• caprolactam degradation

Nomenclature

The systematic name of this enzyme class is (S)-3-hydroxyacyl-CoA:NAD⁺ oxidoreductase. Other names in common use include:

• 1-specific DPN-linked beta-hydroxybutyric dehydrogenase
• 3-hydroxyacetyl-coenzyme A dehydrogenase
• 3-hydroxyacyl coenzyme A dehydrogenase
• 3-hydroxybutyryl-CoA dehydrogenase
• 3-hydroxyisobutyryl-CoA dehydrogenase
• 3-keto reductase
• 3-L-hydroxyacyl-CoA dehydrogenase
• 3beta-hydroxyacyl coenzyme A dehydrogenase
• beta-hydroxy acid dehydrogenase
• beta-hydroxyacyl CoA dehydrogenase
• beta-hydroxyacyl dehydrogenase
• beta-hydroxyacyl-coenzyme A synthetase
• beta-hydroxyacylcoenzyme A dehydrogenase
• beta-hydroxybutyrylcoenzyme A dehydrogenase
• beta-keto-reductase
• beta-ketoacyl-CoA reductase
• L-3-hydroxyacyl CoA dehydrogenase
• L-3-hydroxyacyl coenzyme A dehydrogenase

Structural studies

As of 20 January 2010, 22 structures have been solved for this class of enzymes, with PDB accession codes 1F0Y, 1F12, 1F14, 1F17, 1F67, 1GZ6, 1IKT, 1IL0, 1LSJ, 1LSO, 1M75, 1M76, 1S9C, 1WDK, 1WDL, 1WDM, 1ZBQ, 1ZCJ, 2D3T, 2HDH, 3HAD, and 3HDH.

References

• Hillmer P and Gottschalk G (1974). "Solubilization and partial characterisation of particulate dehydrogenases from Clostridium kluyveri". Biochim. Biophys. Acta 334: 12–23. 
• Lehninger AL, Greville GD (1953). "The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate". Biochim. Biophys. Acta 12 (1-2): 188–202. doi:10.1016/0006-3002(53)90138-3. PMID 13115428. 
• Stern JR (November 1957). "Crystalline beta-hydroxybutyryl dehydrogenase from pig heart". Biochim. Biophys. Acta 26 (2): 448–9. doi:10.1016/0006-3002(57)90040-9. PMID 13499396. 
• Wakil SJ, Green DE, Mii S and Mahler HR (April 1954). "Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase". J. Biol. Chem. 207 (2): 631–8. PMID 13163047. 

UpToDate Contents

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English Journal

• Regular postexercise cooling enhances mitochondrial biogenesis through AMPK and p38 MAPK in human skeletal muscle.

• Ihsan M1, Markworth JF2, Watson G3, Choo HC4, Govus A5, Pham T2, Hickey A2, Cameron-Smith D2, Abbiss CR5.
• American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2015 Aug 1;309(3):R286-94. doi: 10.1152/ajpregu.00031.2015. Epub 2015 Jun 3.
• This study investigated the effect of regular postexercise cold water immersion (CWI) on muscle aerobic adaptations to endurance training. Eight males performed 3 sessions/wk of endurance training for 4 wk. Following each session, subjects immersed one leg in a cold water bath (10°C; COLD) for 15 m
• PMID 26041108

• Production of adipic acid by the native-occurring pathway in Thermobifida fusca B6.

• Deng Y1,2, Mao Y1,2.
• Journal of applied microbiology.J Appl Microbiol.2015 Jul 17. doi: 10.1111/jam.12905. [Epub ahead of print]
• AIMS: To identify the native-occurring adipate pathway in a previously engineered Thermobifida fusca B6 strain and optimize the adipic acid production of this strain on glucose and corncob.METHODS AND RESULTS: The native-occurring adipate pathway in T. fusca B6 was identified to be the reverse adipa
• PMID 26189483

• Oxidative capacity and glycogen content increase more in arm than leg muscle in sedentary women after intense training.

• Nordsborg NB1, Connolly L2, Weihe P3, Iuliano E4, Krustrup P5, Saltin B6, Mohr M7.
• Journal of applied physiology (Bethesda, Md. : 1985).J Appl Physiol (1985).2015 Jul 15;119(2):116-23. doi: 10.1152/japplphysiol.00101.2015. Epub 2015 May 28.
• The hypothesis that the adaptive capacity is higher in human upper- than lower-body skeletal muscle was tested. Furthermore, the hypothesis that more pronounced adaptations in upper-body musculature can be achieved by "low-volume high-intensity" compared with "high-volume low-intensity" exercise tra
• PMID 26023221

Japanese Journal

• Biochemical Characterization of L-Carnitine Dehydrogenases from Rhizobium sp. and Xanthomonas translucens

• ARIMA Jiro,UESUMI Akifumi,MITSUZUMI Hitoshi,MORI Nobuhiro
• Bioscience, biotechnology, and biochemistry 74(6), 1237-1242, 2010-06-23
• … Their primary structures exhibited high identities with those of 3-hydroxyacyl-CoA dehydrogenases. …
• NAID 10027556336

• 短鎖3-ヒドロキシアシル-CoA脱水素酵素欠損症と遺伝子診断した1例

• 七條 光市,梅本 多嘉子,杉本 真弓,松浦 里,東田 栄子,渡邉 力,中津 忠則,吉田 哲也,内藤 悦雄,重松 陽介,平岡 政弘
• 日本小児科学会雑誌 113(11), 1705-1710, 2009-11-01
• NAID 10026276613

Related Links

• 3-hydroxyacyl-CoA dehydrogenase deficiency - Genetics ...

3-hydroxyacyl-CoA dehydrogenase deficiency is an inherited condition that prevents the body from converting certain fats to energy, particularly during prolonged periods without food (fasting). Initial signs and symptoms of ...

• Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency

Long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency is a rare condition that prevents the body from converting certain fats to energy, particularly during periods without food (fasting). Signs and symptoms of ...

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★リンクテーブル★

リンク元	「ペルオキシソーム二頭酵素欠損症」「3-ヒドロキシアシルCoA脱水素酵素」
拡張検索	「long chain 3-hydroxyacyl-CoA dehydrogenase deficiency syndrome」「long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency」「short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency」
関連記事	「C」「CoA」「dehydrogenase」「dehydrogenases」「COA」

「ペルオキシソーム二頭酵素欠損症」

　　[★]

英

peroxisomal bifunctional enzyme

関

ペルオキシソーム、enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase

「3-ヒドロキシアシルCoA脱水素酵素」

　　[★]

英

3-hydroxyacyl-CoA dehydrogenase

関

3-ヒドロキシアシルCoAデヒドロゲナーゼ

「long chain 3-hydroxyacyl-CoA dehydrogenase deficiency syndrome」

　　[★] 長鎖3-ヒドロキシアシルCoA脱水素酵素欠損症候群

「long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency」

　　[★] 長鎖3-ヒドロキシアシルCoA脱水素酵素欠損症

「short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency」

　　[★] 短鎖3-ヒドロキシアシルCoA脱水素酵素欠損症

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「dehydrogenase」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「dehydrogenases」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「COA」

　　[★] 補酵素A coenzyme A CoA