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1. 上皮成長因子受容体変異を有する進行非小細胞肺癌に対する全身療法systemic therapy for advanced non small cell lung cancer with an activating mutation in the epidermal growth factor receptor [show details]
…newer data suggest improved outcomes with front-line treatment with the third-generation agent, osimertinib. Given these data, we prefer osimertinib as the front-line treatment option, although earlier-generation …
2. 小児における身体的診察：HEENTthe pediatric physical examination heent [show details]
… When a light source is held directly in front of a patient who is staring straight ahead,… for visualization of several middle ear structures (umbo, manubrium of the malleus, round window niche, pars flaccida, and chorda tympani nerve) The normal tympanic membrane varies slightly in color and…
3. 中等度および重度のアルコール離脱症候群のマネージメントmanagement of moderate and severe alcohol withdrawal syndromes [show details]
…sedation) is often referred to as "front-loading," as opposed to "symptom-triggered therapy." Although no evidence-based data help to define which patients are most in need of a front-loading strategy, one simple …
4. 自然免疫系の概要an overview of the innate immune system [show details]
…resistant to AMPs and thus may have had an evolutionary advantage over other microbes in adapting to this niche . In fact, human gut microbes from all dominant species can resist even the high levels of AMPs secreted … well-defended host is a reflection of the quiet efficiency of front-line defenses (eg,…
5. 歯の発達障害developmental defects of the teeth [show details]
…to the alveolar ridge between the crowns of the central incisors. Another cause of widely spaced front teeth is a mesiodens, a supernumerary tooth that is located between the maxillary central incisors…