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1. 哺乳類ラパマイシン標的タンパク質（mTOR）阻害薬の薬理学pharmacology of mammalian mechanistic target of rapamycin mtor inhibitors [show details]
…34 percent decrease in the maximum concentration (C_max), a 3.5-fold increase in the time to C_max, and a 35 percent increase in the area under the time-concentration curve (AUC) of sirolimus when …
2. 性腺機能低下を呈する男性の臨床的特徴および診断clinical features and diagnosis of male hypogonadism [show details]
… Increased SHBG concentrations – Aging, hyperthyroidism, high estrogen concentrations, liver disease, HIV, antiseizure drugs; Decreased SHBG concentrations – Moderate obesity,… which reaches a maximum at about 8 AM and a minimum (approximately 70 percent of the maximum) at about 8 PM .… which are determined by its time of onset during reproductive development A clinician…
3. 臨床使用する局所麻酔薬についてclinical use of local anesthetics in anesthesia [show details]
… the maximum plasma concentration is dose dependent . The plasma concentration of bupivacaine exhibits an initial peak… in the preparation, followed by a second peak 10 to 36 hours later. The maximal concentration, time to maximal concentration, and duration of detectable plasma bupivacaine vary widely depending on the injection …
4. シクロスポリンおよびタクロリムスの薬理学pharmacology of cyclosporine and tacrolimus [show details]
…decreased maximum concentration (Cmax) and delayed time to maximum concentration with extended-release formulations. However, extended-release tacrolimus tablets have an AUC0-24 (area under the time concentration …
5. 性腺機能低下を呈する男性に対するテストステロン治療testosterone treatment of male hypogonadism [show details]
… and a maximum of 70 mg, as determined by the serum testosterone concentration. A study in hypogonadal men showed that after 90 days of daily use, the mean serum testosterone concentration before… testosterone concentration increased to slightly higher than the upper limit of normal one to two days after the injection and gradually decreased to the mid-normal range by the time of the next…

Japanese Journal

研究循環時間の標準化とその臨床的意義

新谷冨士雄,井上晃男,赤須文人,渡辺真司,稲木一元,田中政
心臓 16(5), 441-449, 1984
… 補正では消失せず,身長補正で消失した.(2)身長補正による循環時間を循環時間係数と呼ぶことを提唱した.循環時間係数は心拍出量が体表面積補正で標準化されるのと同等な臨床的実用性を有し,とくにtpI(最高濃度時間係数)は身長の高低・男女の別・測定法の別によらず体格の異なる個人間の比較が可能な循環指標であることが示唆された.(3)色素希釈法における心係数と循環時間係数は対等な相互補足的意義を有し,検査 …
NAID 130004411322