参考

1. Multifocal demyelinating neuropathy with persistent conduction block.

Lewis RA, Sumner AJ, Brown MJ, Asbury AK.AbstractWe describe five patients with a chronic asymmetric sensorimotor neuropathy most pronounced in the upper extremities with focal involvement of individual nerves. Diagnosis was established by electrophysiologic evidence of persistent multifocal conduction block. Sural nerve biopsy in three patients showed primarily demyelinating-remyelinating changes with varying degrees of fiber loss. Two patients had acute optic neuritis, indicating that the disorder was not always restricted to the peripheral nervous system. Two patients treated with corticosteroids improved, whereas three untreated patients had static deficits or steady progression of symptoms. Chronic multifocal demyelinating neuropathy with persistent conduction block seems to be a variant of chronic acquired demyelinating polyneuropathy and may be immunologically mediated.
Neurology.Neurology.1982 Sep;32(9):958-64.
We describe five patients with a chronic asymmetric sensorimotor neuropathy most pronounced in the upper extremities with focal involvement of individual nerves. Diagnosis was established by electrophysiologic evidence of persistent multifocal conduction block. Sural nerve biopsy in three patients s
PMID 7202168

2. 多巣性運動ニューロパチーと伝導ブロックの新しい考え方

http://medicalfinder.jp/ejournal/1406100507.html

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1. 慢性炎症性脱髄性多発神経炎：病因、臨床的特徴、および診断chronic inflammatory demyelinating polyneuropathy etiology clinical features and diagnosis [show details]
… can cause multifocal, nonuniform slowing and conduction block. Hereditary neuropathy with liability to pressure palsies, which causes conduction slowing at compression sites.… Certain genetic neuropathies are associated with peripheral nerve demyelination,…
2. 免疫誘導性神経障害immune mediated neuropathies [show details]
… protein without pleocytosis; Nerve conduction evidence of a demyelinating neuropathy; Nerve biopsy evidence of segmental demyelination with or without inflammation;… features among the neuropathies associated with different types of paraprotein . Diagnostic evaluation of a patient with peripheral neuropathy and associated MGUS should include… of nerve conduction, prolonged distal latencies, and severe attenuation of compound muscle action potentials. Conduction block is rarely found, but slowing of motor conduction is proportionately…
3. 神経伝導検査の概要overview of nerve conduction studies [show details]
… hyperpolarization blocks conduction when the safety factor is reduced . Axonal membrane hyperpolarization was found distal to the site of conduction block in multifocal motor neuropathy . In multifocal motor neuropathy… Frequency-dependent conduction block has also been found in patients with carpal tunnel syndrome and significantly prolonged motor latencies. It may explain grip weakness associated with this condition . Conduction block…
4. 多発性神経障害の概要overview of polyneuropathy [show details]
… and nerve conduction study (NCS) testing are known. One clear distinction that can be made by clinical neurophysiology is whether a neuropathy is due to axon loss or demyelination.… homogeneous slowing of conduction across all nerves without conduction block; acquired features generally have more heterogeneous slowing and conduction block,… The polyneuropathies must be distinguished from other diseases of the peripheral nervous system, including the mononeuropathies and mononeuropathy multiplex (multifocal neuropathy),…
5. 成人のギラン・バレー症候群：臨床的特徴と診断guillain barre syndrome in adults clinical features and diagnosis [show details]
… reflecting demyelination at the level of the nerve roots . Increased distal latencies and conduction blocks with temporal dispersion of motor responses follow . Significant slowing of nerve conduction velocities… features in acute motor axonal neuropathy (AMAN) and acute motor and sensory axonal neuropathy (AMSAN). Glycolipid antibodies may be associated with different forms or aspects of GBS .…

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