- 関
- total body irradiation、whole-body radiation
WordNet
- invest with or as with a body; give body to (同)personify
- the external structure of a vehicle; "the body of the car was badly rusted"
- the main mass of a thing
- a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
- the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
- a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
- a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
- an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
- the central message of a communication; "the body of the message was short"
- including all components without exception; being one unit or constituting the full amount or extent or duration; complete; "gave his whole attention"; "a whole wardrobe for the tropics"; "the whole hog"; "a whole week"; "the baby cried the whole trip home"; "a whole loaf of bread"
- an assemblage of parts that is regarded as a single entity; "how big is that part compared to the whole?"; "the team is a unit" (同)unit
- all of something including all its component elements or parts; "Europe considered as a whole"; "the whole of American literature"
- (of siblings) having the same parents; "whole brothers and sisters"
- the condition of being exposed to radiation
- (Pavolvian conditioning) the elicitation of a conditioned response by stimulation similar but not identical to the original stimulus
- (physiology) the spread of sensory neural impulses in the cortex
- the apparent enlargement of a bright object when viewed against a dark background
PrepTutorEJDIC
- 〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
- 《the ~,one's ~ の形で名詞の前に用いて》『全体の』,全部の,全… / 《名詞の前にのみ用いて》(時間・距離などが)『まる』…,満… / (物が)完全な,欠けていない;《名詞の後に置いて》丸ごとで,ひとかたまりに / 《冠詞をつけずに複数名詞の前に用いて》ひじょうに多くの / 《古》(人が)無傷の,(肉体的に)健康な / 整数の,分数を含まない / 〈U〉《the ~》(…の)『全部』,全体,全量《+of+名》 / 〈C〉完全なもの,統一体
- 照らす(照らされる)こと;発光 / (知的)啓発,開明 / 放射線治療
- 《疑問代名詞》『だれが』,どんな人が / 《関係代名詞》(先行詞は「人」) / 《制限用法》(…する,…した)『ところの』 / 《非制限用法》『そしてその人は(を)』,それは…する(した)人だが / 《古》《先行詞を含んで》…する人[はだれでも]
- 《英話》人;(特に)男
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/24 03:50:27」(JST)
[Wiki en表示]
Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation. As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung injury.[1][2] Total body irradiation in the setting of bone marrow transplantation serves to destroy or suppress the recipient's immune system, preventing immunologic rejection of transplanted donor bone marrow or blood stem cells. Additionally, high doses of total body irradiation can eradicate residual cancer cells in the transplant recipient, increasing the likelihood that the transplant will be successful.
Contents
- 1 Dosage
- 2 Usage in other cancers
- 3 Fertility
- 4 References
Dosage
Doses of total body irradiation used in bone marrow transplantation typically range from 10 to >12 Gy. For reference, a dose of 4.5 Gy is fatal in 50% of exposed individuals without aggressive medical care.[3] Such high total body doses are made possible by spreading the total dose out between several sessions, or "fractions," with an interval of time in between allowing other normal tissues some time to repair some of the damage caused. However, at these doses, total body irradiation both destroys the patient's bone marrow (allowing donor marrow to engraft) and kills residual cancer cells. Non-myeloablative bone marrow transplantation uses lower doses of total body irradiation, typically about 2 Gy, which do not destroy the host bone marrow but do suppress the host immune system sufficiently to promote donor engraftment.
In modern practice, total body irradiation is typically fractionated. Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose.[4][5]
Usage in other cancers
In addition to its use in bone marrow transplantation, total body irradiation has been explored as a treatment modality for high-risk Ewing sarcoma.[6] However, subsequent findings suggest that TBI in this setting causes toxicity without improving disease control,[7] and TBI is not currently used in the treatment of Ewing sarcoma outside of clinical trials.
Fertility
Total body irradiation results in female infertility in most cases, with recovery of gonadal function occurring in 10−14% of cases. The number of pregnancies observed after hematopoietic stem cell transplantation involving such as procedure is lower than 2%.[8] Fertility preservation measures mainly include cryopreservation of ovarian tissue, embryos or oocytes.
References
- ^ Gore EM, Lawton CA, Ash RC, Lipchik RJ (August 1996). "Pulmonary function changes in long-term survivors of bone marrow transplantation". Int. J. Radiat. Oncol. Biol. Phys. 36 (1): 67–75. doi:10.1016/S0360-3016(96)00123-X. PMID 8823260.
- ^ Soule BP, Simone NL, Savani BN, et al. (September 2007). "Pulmonary function following total body irradiation (with or without lung shielding) and allogeneic peripheral blood stem cell transplant". Bone Marrow Transplant. 40 (6): 573–8. doi:10.1038/sj.bmt.1705771. PMID 17637691.
- ^ Department of Homeland Security Working Group on Radiological Dispersal Device (RDD) Preparedness, from the United States Department of Homeland Security. Accessed May 29, 2008.
- ^ Thomas ED, Buckner CD, Clift RA, et al. (September 1979). "Marrow transplantation for acute nonlymphoblastic leukemia in first remission". N. Engl. J. Med. 301 (11): 597–9. doi:10.1056/NEJM197909133011109. PMID 381925.
- ^ Thomas ED, Clift RA, Hersman J, et al. (May 1982). "Marrow transplantation for acute nonlymphoblastic leukemic in first remission using fractionated or single-dose irradiation". Int. J. Radiat. Oncol. Biol. Phys. 8 (5): 817–21. PMID 7050046.
- ^ Kinsella TJ, Glaubiger D, Diesseroth A, et al. (December 1983). "Intensive combined modality therapy including low-dose TBI in high-risk Ewing's Sarcoma Patients". Int. J. Radiat. Oncol. Biol. Phys. 9 (12): 1955–60. doi:10.1016/0360-3016(83)90368-1. PMID 9463099.
- ^ Burdach S, Meyer-Bahlburg A, Laws HJ, et al. (August 2003). "High-dose therapy for patients with primary multifocal and early relapsed Ewing's tumors: results of two consecutive regimens assessing the role of total-body irradiation". J. Clin. Oncol. 21 (16): 3072–8. doi:10.1200/JCO.2003.12.039. PMID 12915596.
- ^ André Tichelli, Alicia Rovó. Fertility Issues Following Hematopoietic Stem Cell Transplantation. Expert Rev Hematol. 2013;6(4):375-388.
In turn citing:Salooja N, Szydlo RM, Socie G et al. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet 358(9278), 271–276(2001).
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Organ transplantation
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| Types |
- Allotransplantation
- Autotransplantation
- Xenotransplantation
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| Organs and tissues |
- Bone
- Bone marrow
- Brain
- Corneal
- Face
- Hand
- Head
- Heart
- Heart–lung
- Intestine
- Kidney
- Liver
- Lung
- Pancreas
- Penis
- Skin
- Spleen
- Thymus
- Uterus
- Vagina
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| Medical grafting |
- Bone grafting
- Skin grafting
- Vascular grafting
|
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| Organ donation |
- Non-heart-beating donation
- Organ harvesting
- Organ trade
|
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| Complications |
- Graft-versus-host disease
- Post-transplant lymphoproliferative disorder
- Transplant rejection
|
|
| Organizations |
- Anthony Nolan
- Eurotransplant
- Halachic Organ Donor Society
- Human Tissue Authority
- National Marrow Donor Program
- National Transplant Organization
- NHS Blood and Transplant
- United Network for Organ Sharing
|
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| Countries |
- Organ transplantation in different countries
- Organ transplantation in China
- Organ transplantation in Israel
- Organ transplantation in Japan
- Organ theft in Kosovo
- Gurgaon kidney scandal
|
|
| People |
| Heart |
- Christiaan Barnard
- James D. Hardy
- Adrian Kantrowitz
- Richard Lower
- Norman Shumway
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|
| Kidney |
- J. Hartwell Harrison
- John P. Merrill
- Joseph Murray
- Michael Woodruff
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| Liver |
- Fikri Alican
- James D. Hardy
- Thomas Starzl
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| Lung |
- Fikri Alican
- Joel D. Cooper
- Vladimir Demikhov
- James D. Hardy
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| Penis |
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| Other |
- Alexis Carrel
- Jean-Michel Dubernard
- Donna Mansell
- Bruce Reitz
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- List of organ transplant donors and recipients
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|
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| Related topics |
- Biomedical tissue
- Edmonton protocol
- Eye bank
- Immunosuppressive drugs
- Lung allocation score
- Machine perfusion
- Total body irradiation
- Frankenstein's monster
|
UpToDate Contents
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English Journal
- Protective effect of the antioxidative peptide SS31 on ionizing radiation-induced hematopoietic system damage in mice.
- Han X, Gao P, Zhang Y, Wang J, Sun F, Liu Q, Zhang S.
- Blood cells, molecules & diseases. 2019 Jul;77()82-87.
- Ionizing radiation (IR) causes severe damage to the hematopoietic system; thus, it is necessary to explore agents or compounds that can reduce this damage. SS31 is a mitochondria-targeted peptide that can scavenge cellular reactive oxygen species (ROS) and inhibit the production of mitochondrial ROS
- PMID 31005751
- Prospective comparison of whole-body MRI and Ga-PSMA PET/CT for the detection of biochemical recurrence of prostate cancer after radical prostatectomy.
- Sawicki LM, Kirchner J, Buddensieck C, Antke C, Ullrich T, Schimmöller L, Boos J, Schleich C, Schaarschmidt BM, Buchbender C, Heusch P, Rabenalt R, Albers P, Antoch G, Müller HW, Hautzel H.
- European journal of nuclear medicine and molecular imaging. 2019 Jul;46(7)1542-1550.
- To assess whole-body magnetic resonance imaging (wb-MRI) for detection of biochemical recurrence in comparison to Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) in prostate cancer (Pca) patients after radical prostatectomy. This was a prospect
- PMID 30879122
- Effect of ionizing radiation on physiological and molecular processes in plants.
- Gudkov SV, Grinberg MA, Sukhov V, Vodeneev V.
- Journal of environmental radioactivity. 2019 Jun;202()8-24.
- The study of effects of ionizing radiation (IR) on plants is important in relation to several problems: (I) the existence of zones where background radiation - either natural or technogenic - is increased; (II) the problems of space biology; (III) the use of IR in agricultural selection; (IV) genera
- PMID 30772632
Japanese Journal
- Effect of Whole Body X-irradiation on the Rat Glutathione-related Antioxidant System
- Ishikawa Takashi,Kudo Shinya,Sato Yuya [他]
- Radiation emergency medicine 2(2), 49-55, 2013-08
- NAID 40019745080
- 高齢者に発症し放射線療法が奏効した頭部巨大有棘細胞癌の1例
- 穀内 康人,兪 明寿,黒川 晃夫,上田 英一郎,森脇 真一
- Skin Cancer 27(3), 322-325, 2013
- 99歳，男性。2010年5月頃より頭部に皮膚腫瘤が出現，徐々に増大傾向を示したため同年12月，当院を受診した。初診時，前頭部左側，頭頂部やや後方にそれぞれ径3.5×3cm，5.5×5cm，中央にクレーター状の潰瘍を伴う皮膚腫瘤とその周囲にびまん性の紅斑を認めた。血中SCC関連抗原は5.2ng/mlと高値であった。皮膚生検を行い病理組織検査にて有棘細胞癌と診断，PET－CTを施行したがリンパ節転移 …
- NAID 130003378145
- Toxicogenomics/proteomics Report : Protein array profiling of mouse serum, six months post whole body radiation with ⁵⁶Fe
- Chatterjee Anuran,Diordieva Inna,Yumoto Kenji [他],GLOBUS Ruth K.,BHATTACHARYA Sharmila
- Journal of toxicological sciences 37(1), 215-217, 2012-02-01
- … To determine the chronic effects of heavy ion irradiation, an antibody based proteomic microarray technology was applied to monitor alterations in the serum proteome, six months after whole body irradiation of adult male C57Bl/6 mice with 0.5 Gray of 56Fe. … Out of 507 proteins, irradiation reduced expression of 25 proteins and enhanced expression of 12 proteins in serum (> …
- NAID 10030037906
Related Links
- Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation. As the name implies, TBI involves irradiation of the entire body, though in ...
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- 関
- total body irradiation、whole-body irradiation
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- 関
- whom
- who whom whose
- which wihich whose
- 関
- World Health Organization
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- 関
- altogether、entire、entirety、gross、overall、total
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- bombardment、illuminate、irradiate、radiate、radiation
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- general、systemic、total body、whole-body
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