vitamin B12-refractory megaloblastic anemia

ビタミンB12不応性巨赤芽球性貧血

WordNet

1. temporarily unresponsive or not fully responsive to nervous or sexual stimuli; "the refractory period of a muscle fiber"
2. not responding to treatment; "a stubborn infection"; "a refractory case of acne"; "stubborn rust stains" (同)stubborn
3. the 2nd letter of the Roman alphabet (同)b
4. the blood group whose red cells carry the B antigen (同)type_B, group B
5. any of a group of organic substances essential in small quantities to normal metabolism
6. a deficiency of red blood cells (同)anaemia
7. a lack of vitality (同)anaemia
8. abnormally large red blood cell present in pernicious anemia and folic acid deficiency

PrepTutorEJDIC

1. (人などが)手に負えない,強情な / (病気が)治りにくい,がんこな / (金属などが)溶けにくい,耐火性の
2. 『ビタミン』,栄養素(身体の喜常な機能を維持するために少量ながら必要な有機化合物)

UpToDate Contents

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• 1. ビタミンB12欠乏や葉酸欠乏の臨床症状と診断 clinical manifestations and diagnosis of vitamin b12 and folate deficiency
• 2. ビタミンB12欠乏や葉酸欠乏の原因と病態生理 causes and pathophysiology of vitamin b12 and folate deficiencies
• 3. ビタミンB12欠乏や葉酸欠乏の治療 treatment of vitamin b12 and folate deficiencies
• 4. 大赤血球症/大球性貧血 macrocytosis macrocytic anemia
• 5. 原因不明の汎血球減少症が生じた成人へのアプローチ approach to the adult with unexplained pancytopenia

English Journal

• Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32.

• Lohmann AE1,2, Liebman MF3, Brien W4, Parulekar WR5, Gelmon KA6, Shepherd LE5, Ligibel JA7, Hershman DL8, Rastogi P9, Mayer IA10, Hobday TJ11, Lemieux J12, Thompson AM13, Pritchard KI14, Whelan TJ15, Mukherjee SD15, Chalchal HI16, Bernstein V17, Stambolic V18, Chen BE5, Goodwin PJ19,20; From the CCTG, Alliance, SWOG, ECOG, NSABP Cooperative Groups.
• Breast cancer research and treatment.Breast Cancer Res Treat.2017 Jul;164(2):371-378. doi: 10.1007/s10549-017-4265-x. Epub 2017 Apr 26.
• PMID 28447237

• Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin.

• Arora K1, Sequeira JM2, Quadros EV3.
• FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2017 Jul;31(7):3098-3106. doi: 10.1096/fj.201700025R. Epub 2017 Mar 28.
• PMID 28351841

• Efficacy of oral methylcobalamin in treatment of vitamin B12 deficiency anemia in children.

• Verma D1, Chandra J1, Kumar P1, Shukla S2, Sengupta S3.
• Pediatric blood & cancer.Pediatr Blood Cancer.2017 Jul 1. doi: 10.1002/pbc.26698. [Epub ahead of print]
• PMID 28667789

Related Links

• Megaloblastic anemia. - National Center for Biotechnology ...

1. Postgrad Med. 1978 Oct;64(4):117-22. Megaloblastic anemia. Castle WB. Most, but not all, megaloblastic anemia is produced by "ineffective erythropoiesis" in the bone marrow due to either folic acid or vitamin B12 ...

• Refractory megaloblastic anemia. - ResearchGate - Share and ...

Megaloblasts are seen in the marrow of patients with pernicious anemia and related anemias due to (leficiency of vitamin B12 and folic acid in relapse; and following the administration of specific therapy they rapidly disappear , ...

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★リンクテーブル★

リンク元	「ビタミンB12不応性巨赤芽球性貧血」
関連記事	「refractory」「B」「megaloblastic」「megaloblast」「vitamin B12」

「ビタミンB12不応性巨赤芽球性貧血」

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英

vitamin B12-refractory megaloblastic anemia

「refractory」

　　[★]

• adj.

• 手に負えない、御しがたい
• (病気などが)難治性の、抗療性の。(刺激に)不応性の、無反応性の。抵抗性がある、免疫性の(to)

関

intractable、inveterate、recalcitrance、recalcitrant、refractoriness、resistance、resistant、resistive

　 　 　

「B」

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• 気管分岐部下緑
• 補体のalternative pathwayに関わる蛋白質

• Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

　 　

「megaloblastic」

　　[★]

• 巨赤芽球性の、巨赤芽球の、巨大赤芽球の

関

megaloblast

　

「megaloblast」

　　[★]

• 巨赤芽球、巨大赤芽球

　

「vitamin B12」

　　[★] ビタミンB12 cobalamin