巨赤芽球、巨大赤芽球

WordNet

abnormally large red blood cell present in pernicious anemia and folic acid deficiency
of or relating to megaloblasts

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/15 23:41:15」(JST)

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A megaloblast is an unusually large erythroblast that can be associated with Vitamin B₁₂ deficiency (as caused by pernicious anemia or dietary insufficiency) and/or folic acid deficiency (collectively called megaloblastic anemia). It is differentiated from a normoblast, which is a normally-sized erythroblast. This kind of anemia leads to macrocytes (abnormally large red cells). The cause of this cellular gigantism is an impairment in DNA synthesis which delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony.

Additional images

Blood cell lineage
Hematopoiesis

External links

Pronormoblasts Presented by the University of Virginia
Basophilic Normoblasts Presented by the University of Virginia
Polychromatophilic Normoblasts Presented by the University of Virginia
Orthochromatic Normoblasts Presented by the University of Virginia
"Megaloblast" at Dorland's Medical Dictionary

"Normoblast" at Dorland's Medical Dictionary

"Erythroblast" at Dorland's Medical Dictionary

Normoblasts at the US National Library of Medicine Medical Subject Headings (MeSH)
Histology image: 01804loa – Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
Histology at uiowa.edu

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1. ビタミンB12および葉酸欠乏症の生理学 physiology of vitamin b12 and folate deficiency
2. 大赤血球症 macrocytosis
3. ビタミンB12および葉酸欠乏症の病因および臨床症状 etiology and clinical manifestations of vitamin b12 and folate deficiency

English Journal

Huge multinucleated megaloblasts found in a patient with refractory anemia with excess blasts-1.

Ohgiya D, Matsushita H, Kojima M, Ando K.SourceDepartment of Hematology/Oncology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan, giya_pen_1213.0@triton.ocn.ne.jp.
International journal of hematology.Int J Hematol.2012 Oct 26. [Epub ahead of print]
PMID 23099925

[Pronounced pancytopenia with concomitant jaundice in a 66-year-old woman].

Kächele V, Schneider-Kappus W, Bommer M.SourceHämato-Onkologische Praxis Ulm. volker.kaechele@gmx.de
Deutsche medizinische Wochenschrift (1946).Dtsch Med Wochenschr.2012 Aug;137(34-35):1693-6. doi: 10.1055/s-0032-1305226. Epub 2012 Aug 14.
HISTORY AND ADMISSION FINDINGS: A previously healthy 66-year-old women presented with onset of general weakness, shortness of breath and significant weight loss. Due to appearance of jaundice, biliary obstruction had been ruled out by a CAT scan previous to the patients presentation in our practice.
PMID 22893049

Japanese Journal

再メチル化障害により退行を示しベタイン食療法が効果を示した1例

島田姿野,舟塚真,中陣瑠美 [他],平野嘉子,伊藤進,吉井啓介,石垣景子,大澤真木子,SHIMADA Shino,FUNATSUKA Makoto,NAKAJIN Rumi,HIRANO Yoshiko,ITO Susumu,YOSHII Keisuke,ISHIGAKI Keiko,OSAWA Makiko
東京女子医科大学雑誌 83(E1), E307-E312, 2013-01-31
メチオニン、ホモシステインはDNAメチル化において重要な働きを担い、メチル基転移反応の中心的な役割を担う。脳は遺伝子の厳密な調整を必要とする臓器でありDNAメチル化により遺伝子発現調節を行う。故にメチル基転移機構の異常はしばしば重篤な神経疾患を引き起こしうる。今回、アミノ酸代謝異常による再メチル化障害により急激な退行を来たし、ベタイン食事療法により神経症状の改善を認めた一例につき報告した。症例は9 …
NAID 110009559396

Huge multinucleated megaloblasts found in a patient with refractory anemia with excess blasts-1

OHGIYA Daisuke,MATSUSHITA Hiromichi,KOJIMA Minoru,ANDO Kiyoshi
International journal of hematology 96(5), 531-532, 2012-11-01
NAID 10031126748

Anemia in the Aged

仁田正和,小出幸夫,松原充隆,佐藤磐男,中野小枝子,新美達司,前田甲子郎
日本老年医学会雑誌 16(4), 346-352, 1979
… There were some folate-deficiency anemia which had a few megaloblast in bone marrow showed hypersegmented neutrophils. …
NAID 130003651300