WordNet

of long duration; not new; "old tradition"; "old house"; "old wine"; "old country"; "old friendships"; "old money"
past times (especially in the phrase `in days of old'
skilled through long experience; "an old offender"; "the older soldiers" (同)older
(used especially of persons) having lived for a relatively long time or attained a specific age; "his mother is very old"; "a ripe old age"; "how old are you?"
(used for emphasis) very familiar; "good old boy"; "same old story"
precisely so; "on the very next page"; "he expected the very opposite"
used as intensifiers; `real is sometimes used informally for `really; `rattling is informal; "she was very gifted"; "he played very well"; "a really enjoyable evening"; "Im real sorry about it"; "a rattling good yarn" (同)really, real, rattling
precisely as stated; "the very center of town"
of a very early stage in development; "Old English is also called Anglo Saxon"; "Old High German is High German from the middle of the 9th to the end of the 11th century"

PrepTutorEJDIC

『年とった』,老齢の / 『年上の』,年長の / 『ある年月』(『年齢』)『の』,…歳の / (物事が)『古い』,古くさい,新しくない / 《名詞の前にのみ用いて》『昔なじみの』,昔なつかしい / 《名詞の前にのみ用いて》『古代の』,大昔の / 《名詞の前にのみ用いて》(現在に対して)以前の,もとの / (衣服など)使い古した / (人が)経験のある,老練な / 《話》《呼び掛けで親しみなどをこめて》 / 《話》《名詞の前にのみ用い,前の形容詞を強めて》非常な,すばらしい / 昔
《副詞・形容詞・分詞形容詞を強めて》『非常に』,とても,たいへん,きわめて / 《否定語と共に用いて》『あまり』,さほど,たいして(…でない) / 《same, opposite, [one's]ownなどの前で》『真に,まったく』,ほんとうに / 《古》まったくの,本物の,真の / 《the(this,that,one's)~》『まさにその』,ちょうどその / 《the(one's)~》ただ…だけで(mere);(…)でさえ,までも(even)

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1. 脂質疾患に対するスクリーニング screening for lipid disorders
2. 肝生検標本の解釈 interpretation of liver biopsy specimens
3. 高齢者における高血圧、特に収縮期高血圧の治療 treatment of hypertension in the elderly patient particularly isolated systolic hypertension
4. 冠動脈ステント血栓症：発症率および危険因子 coronary artery stent thrombosis incidence and risk factors
5. 中等度～高、超高リスク限局性前立腺癌の初期マネージメント initial management of regionally localized intermediate high and very high risk prostate cancer

English Journal

Bilateral femoral neck insufficiency fractures secondary to vitamin D deficiency and concurrent corticosteroid use--a case report.

Carter T1, Nutt J, Simons A.Author information 1Department of Orthogeriatrics, Birmingham Heartlands Hospital, Birmingham, UK, tjcarter@doctors.org.uk.AbstractWe present a rare case of a 67-year-old Indian female who was found to have bilateral insufficiency of the neck of femur fractures secondary to osteomalacia from vitamin D deficiency, with her symptoms exacerbated by a course of oral steroids prescribed for suspected polymyalgia rheumatica.
Archives of osteoporosis.Arch Osteoporos.2014 Dec;9(1):172. doi: 10.1007/s11657-014-0172-5. Epub 2014 Feb 11.
We present a rare case of a 67-year-old Indian female who was found to have bilateral insufficiency of the neck of femur fractures secondary to osteomalacia from vitamin D deficiency, with her symptoms exacerbated by a course of oral steroids prescribed for suspected polymyalgia rheumatica.INTRODUCT
PMID 24515953

Differential toxicological response to positively and negatively charged nanoparticles in the rat brain.

Knudsen KB1, Northeved H, Ek PK, Permin A, Andresen TL, Larsen S, Wegener KM, Lam HR, Lykkesfeldt J.Author information 1Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.AbstractWe investigated the potential for systemic and local toxicity after administration of empty nanosized anionic and cationic PEGylated-micelles and non-PEGylated liposomes, without a ligand attached, intended for use in drug-delivery systems. The particles were administered to 5-6-week-old male rats by three intravenous (IV) administrations over a period of one week at a dose of 100 mg/kg bodyweight or after a single intracerebroventricular (ICV) injection at a dose of 50 µg. The particles were stable and well characterised with respect to size and zeta potential. ICV administration of cationic particles was associated with histological changes near the injection site (hippocampus). Here, we detected focal infiltration with phagocytic cells, loss of neurons and apoptotic cell death, which were not observed after administration of the vehicle. No significant difference was found after IV or ICV administration of the anionic micelles with regard to haematology, clinical chemistry parameters or at the pathological examinations, as compared to control animals. Our study suggests that ICV delivery of cationic particles to the brain tissue is associated with toxicity at the injection site.
Nanotoxicology.Nanotoxicology.2014 Nov;8(7):764-74. doi: 10.3109/17435390.2013.829589.
We investigated the potential for systemic and local toxicity after administration of empty nanosized anionic and cationic PEGylated-micelles and non-PEGylated liposomes, without a ligand attached, intended for use in drug-delivery systems. The particles were administered to 5-6-week-old male rats b
PMID 23889261

Induction of thyroid neoplasm following plant medicine marine algae (sargassum): a rare case and review of the literature.

Zhu G, Musumeci F, Byrne P1.Author information 1Institute of Oncology of George Zhu, 422407, Beijing, China. sansan4240732@163.com.AbstractIn this study induction of neoplasm in thyroid gland of one postoperative patient with breast cancer was conducted by marine algae (also seaweed, sargassum), which is presented here. A 41-year-old women was diagnosed as her right breast cancer complicated with lymph node metastasis in her right axilla on February, 1999. In June 19, 1999 she was given the combination chemotherapy of vincristine, cyclophosphamide, 5-Fluorouracil and cinobufacini drugs due to two lymph nodes on her right superclavicular following radical mastectomy. During chemotherapy she was also taken the adjuvant treatment of traditional medicine. Traditional medicine consisted of seaweed plant drugs (containing iodine 362,400 ug/kg). As to intermittent maintance treatment the total dosage of seaweed herb was at least exceeded 500 gram. Induction of thyroid tumor (thumb size) was found in June, 2001. A thyroidectomy due to thyroma was successfully performed. Histologically there revealed thyroid tissue without the evidence of metastasis of breast cancer. She had a 5-year survivor. The data indicated oncogenic function of some traditional herbs, and further experience of traditional medicine in treating thyroid disease especially in thyroid cancer.
Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Oct;14(9):859-63.
In this study induction of neoplasm in thyroid gland of one postoperative patient with breast cancer was conducted by marine algae (also seaweed, sargassum), which is presented here. A 41-year-old women was diagnosed as her right breast cancer complicated with lymph node metastasis in her right axil
PMID 24433506