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an operation to repair a damaged blood vessel or unblock a coronary artery

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/25 12:34:42」(JST)

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Vasculogenesis is the process of blood vessel formation occurring by a de novo production of endothelial cells.^[1]

Process

Though similar to angiogenesis, the two are different in one aspect: The term angiogenesis denotes the formation of new blood vessels from pre-existing ones,^[2] whereas vasculogenesis is the term used for the formation of new blood vessels when there are no pre-existing ones.^[3] For example, if a monolayer of endothelial cells begins sprouting to form capillaries, angiogenesis is occurring. Vasculogenesis, in contrast, is when endothelial precursor cells (angioblasts) migrate and differentiate in response to local cues (such as growth factors and extracellular matrices) to form new blood vessels. These vascular trees are then pruned and extended through angiogenesis.

Occurrences

Vasculogenesis occurs during embryologic development of the circulatory system.

Vasculogenesis can also occur in the adult organism from circulating endothelial progenitor cells (derivatives of stem cells) able to contribute, albeit to varying degrees, to neovascularization. Examples of where vasculogenesis can occur in adults are:

Tumor growth (see HP59)
Revascularization following trauma, e.g., after cardiac ischemia
Endometriosis - It appears that that up to 37% of the microvascular endothelium of the ectopic endometrial tissue originates from endothelial progenitor cells.^[4]

References

^ John S. Penn (11 March 2008). Retinal and Choroidal Angiogenesis. Springer. pp. 119–. ISBN 978-1-4020-6779-2. Retrieved 26 June 2010.
^ Birbrair, A.; Zhang, T.; Wang, Z.-M.; Messi, M. L.; Olson, J. D.; Mintz, A.; Delbono, O. (2014). "Type-2 pericytes participate in normal and tumoral angiogenesis". AJP: Cell Physiology 307 (1): C25. doi:10.1152/ajpcell.00171.2013.
^ "Endoderm -- Developmental Biology -- NCBI Bookshelf". Retrieved 2010-04-07.
^ Laschke, M. W.; Giebels, C.; Menger, M. D. (2011). "Vasculogenesis: A new piece of the endometriosis puzzle". Human Reproduction Update 17 (5): 628–636. doi:10.1093/humupd/dmr023. PMID 21586449. edit

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1. 気管支肺異形成症の病因および臨床的特徴 pathogenesis and clinical features of bronchopulmonary dysplasia
2. 子癇前症の病因 pathogenesis of preeclampsia
3. 難治性狭心症マネージメントのための血管新生療法 therapeutic angiogenesis for management of refractory angina
4. 冠側副循環 coronary collateral circulation
5. 胎盤の発達および生理学 placental development and physiology

English Journal

Inducing the migration behavior of endothelial cells by tuning the ligand density on a density-gradient poly(ethylene glycol) surface.

Li T1, Xu K1, Fu Y2, Cai K3.
Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2016 Jul 1;143:557-64. doi: 10.1016/j.colsurfb.2016.03.074. Epub 2016 Mar 26.
The migration of endothelial cells (ECs) is crucially important for many biological processes, including early embryonic vasculogenesis, wound healing and angiogenesis. To investigate the effect of the surface poly(ethylene glycol) (mPEG-CHO) density on the migration of ECs, we developed a convenien
PMID 27058513

Mesenchymal stem cells generate pericytes to promote tumor recurrence via vasculogenesis after stereotactic body radiation therapy.

Wang HH1, Cui YL2, Zaorsky NG3, Lan J4, Deng L4, Zeng XL1, Wu ZQ1, Tao Z1, Guo WH5, Wang QX1, Zhao LJ1, Yuan ZY1, Lu Y4, Wang P1, Meng MB6.
Cancer letters.Cancer Lett.2016 Jun 1;375(2):349-59. doi: 10.1016/j.canlet.2016.02.033. Epub 2016 Mar 17.
BACKGROUND: Stereotactic body radiation therapy (SBRT) is postulated to enhance the recruitment of mesenchymal stem cells (MSCs) into the tumor microenvironment, which promote tumor recurrence. The aim of this study is to determine the molecular mechanisms behind SBRT stimulating MSC migration and d
PMID 26996301

De novo development of a cerebral arteriovenous malformation following radiation therapy: Case report and an update to classical arteriovenous malformation nomenclature.

Koch MJ1, Agarwalla PK2, Stapleton CJ2, Ogilvy CS3, Loeffler JS4.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.J Clin Neurosci.2016 Jun;28:162-7. doi: 10.1016/j.jocn.2015.11.021. Epub 2016 Feb 6.
Cerebral arteriovenous malformations (AVM) are traditionally considered primary congenital lesions that result from embryological aberrations in vasculogenesis. Recent insights, however, suggest that these lesions may be secondary to a vascular insult such as ischemia or trauma. Herein, the authors
PMID 26860850

Japanese Journal

血管パターン形成の理論モデル

福岡医学雑誌 = Fukuoka acta medica 107(9), 161-168, 2016-09-25
NAID 120005898466

Angiogenesis in refractory depression: A possible phenotypic target to avoid the blood brain barrier

Drug Discoveries & Therapeutics 10(2), 74-78, 2016
NAID 130005152847

Angiogenesis in refractory depression: A possible phenotypic target to avoid the blood brain barrier

Drug Discoveries & Therapeutics advpub(0), 2016
NAID 130005127114

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