WordNet

occurring or encountered or experienced or observed frequently or in accordance with regular practice or procedure; "grew the usual vegetables"; "the usual summer heat"; "came at the usual time"; "the childs usual bedtime"
of or relating to interstices
inflammation of the lungs; caused by a virus or an allergic reaction

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『いつもの』,通例の,おきまりの

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1. 特発性間質性肺炎：臨床症状および病理 idiopathic interstitial pneumonias clinical manifestations and pathology
2. 間質性肺疾患を有する成人に対するアプローチ：臨床的評価 approach to the adult with interstitial lung disease clinical evaluation
3. 間質性肺疾患を有する成人に対するアプローチ：診断的検査 approach to the adult with interstitial lung disease diagnostic testing
4. 非特異的間質性肺炎 nonspecific interstitial pneumonia
5. 関節リウマチにおける間質性肺疾患 interstitial lung disease in rheumatoid arthritis

English Journal

Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice.

Aalapati S, Ganapathy S, Manapuram S, Anumolu G, Prakya BM.Author information Department of Toxicology, International Institute of Biotechnology and Toxicology [IIBAT] , Chennai , India.AbstractMale CD1 mice were subjected to nose-inhalation exposure of CeO2 nanoparticles (NPs) for 0, 7, 14 or 28 days with 14 or 28 days of recovery time at an aerosol concentration of 2 mg/m(3). Markers of lung injury and pro-inflammatory cytokines (interleukin-1beta, tumour necrosis factor-alpha, interleukin-6 and macrophage inflammatory protein-2) in bronchoalveolar lavage fluid (BALF), oxidative stress in lungs, bio-accumulation, and histopathology of pulmonary and extrapulmonary tissues were assessed. BALF analysis revealed the induction of pulmonary inflammation, as evident by an increase in the influx of neutrophils with a significant secretion of pro-inflammatory cytokines that lead to generation of oxidative stress and cytotoxicity, as is evident by induction of lipid peroxidation, depletion of glutathione and increased BALF lactate dehydrogenase and protein. The histopathological examination revealed that these inhaled CeO2 NPs were located all over the pulmonary parenchyma, inducing a severe, chronic, active inflammatory response characterised by necrosis, proteinosis, fibrosis and well-formed discrete granulomas in the pulmonary tissue and tubular degeneration leading to coagulative necrosis in kidneys. Inductively coupled plasma optical emission spectrometer results showed a significant bio-accumulation of these particles in the pulmonary and extrapulmonary tissues, even after one month of post-inhalation exposure. Together, these findings suggest that inhalation exposure of CeO2 NPs can induce pulmonary and extrapulmonary toxicity.
Nanotoxicology.Nanotoxicology.2014 Nov;8(7):786-98. doi: 10.3109/17435390.2013.829877. Epub 2013 Aug 22.
Male CD1 mice were subjected to nose-inhalation exposure of CeO2 nanoparticles (NPs) for 0, 7, 14 or 28 days with 14 or 28 days of recovery time at an aerosol concentration of 2 mg/m(3). Markers of lung injury and pro-inflammatory cytokines (interleukin-1beta, tumour necrosis factor-alpha, interleuk
PMID 23914771

Cardiopulmonary toxicity of pulmonary exposure to occupationally relevant zinc oxide nanoparticles.

Chuang HC, Juan HT, Chang CN, Yan YH, Yuan TH, Wang JS, Chen HC, Hwang YH, Lee CH, Cheng TJ.Author information School of Respiratory Therapy, College of Medicine, Taipei Medical University , Taipei , Taiwan.AbstractExposure to zinc oxide (ZnO) metal fumes is linked to adverse human health effects; however, the hazards of ZnO nanoparticles (ZnONPs) remain unclear. To determine pulmonary exposure to occupationally relevant ZnONPs cause cardiopulmonary injury, Sprague-Dawley rats were exposed to ZnONPs via intratracheal (IT) instillation and inhalation. The relationship between intrapulmonary zinc levels and pulmonary oxidative-inflammatory responses 72 h after ZnONP instillation was determined in bronchoalveolar lavage fluid (BALF). Instilled ZnONPs altered zinc balance and increased the levels of total cells, neutrophils, lactate dehydrogenase (LDH) and total protein in BALF and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in blood after 72 h. The ZnONPs accumulated predominantly in the lungs over 24 h, and trivial amounts of zinc were determined in the heart, liver, kidneys and blood. Furthermore, the inflammatory-oxidative responses induced by occupationally relevant levels of 1.1 and 4.9 mg/m(3) of ZnONP inhalation for 2 weeks were determined in BALF and blood at 1, 7 and 30 days post-exposure. Histopathological examinations of the rat lungs and hearts were performed. Inhalation of ZnONP caused an inflammatory cytological profile. The total cell, neutrophil, LDH and total protein levels were acutely increased in the BALF, and there was an inflammatory pathology in the lungs. There were subchronic levels of white blood cells, granulocytes and 8-OHdG in the blood. Cardiac inflammation and the development of fibrosis were detected 7 days after exposure. Degeneration and necrosis of the myocardium were detected 30 days after exposure. The results demonstrate that ZnONPs cause cardiopulmonary impairments. These findings highlight the occupational health effects for ZnONP-exposed workers.
Nanotoxicology.Nanotoxicology.2014 Sep;8(6):593-604. doi: 10.3109/17435390.2013.809809. Epub 2013 Jun 25.
Exposure to zinc oxide (ZnO) metal fumes is linked to adverse human health effects; however, the hazards of ZnO nanoparticles (ZnONPs) remain unclear. To determine pulmonary exposure to occupationally relevant ZnONPs cause cardiopulmonary injury, Sprague-Dawley rats were exposed to ZnONPs via intrat
PMID 23738974

A3.34 The global microrna profile of skin in systemic sclerosis.

Salazar GA, Assassi S, Wu M, Hagan J, Mayes MD.Author information University of Texas Medical School at Houston, Houston TX, USA. Division of Rheumatology.AbstractBACKGROUND: The underlying pathogenesis of systemic sclerosis (SSc) remains poorly understood contributing to limited efficacy of therapeutic options. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in post-transcriptional gene regulation.(1,2) Two families of dysregulated miRNAs, miR-21 and miR-29, have been implicated in the pathogenesis of fibrotic diseases and replicated in SSc. (3-6,7,9) These studies focused on a miRNA of interest and global skin miRNA profiling in SSc has not been reported. Recent advances in quantitative polymerase chain reaction (qPCR) allow simultaneous measurement of hundreds of miRNAs. The objective of this study was to use this technology to identify the unbiased, global miRNA profiling of SSc skin and evaluate their potential role in its pathogenesis.
Annals of the rheumatic diseases.Ann Rheum Dis.2014 Mar 1;73 Suppl 1:A55-6. doi: 10.1136/annrheumdis-2013-205124.127.
BACKGROUND: The underlying pathogenesis of systemic sclerosis (SSc) remains poorly understood contributing to limited efficacy of therapeutic options. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in post-transcriptional gene regulation.(1,2) Two families of dysregulated m
PMID 24489251

Japanese Journal

UIP : 二次性vs.特発性の異同 (特集びまん性肺疾患の最新情報)

佐藤敬太,本間栄
呼吸器内科 25(2), 121-127, 2014-02
NAID 40019988689

BAL Fluid Concentrations of Cytokines in Patients with Nonspecific Interstitial Pneumonia, Usual Interstitial Pneumonia, Collagen Vascular Disease Associated with Interstitial Pneumonia, and Sarcoidosis

Fukushima Fumiya,Hirata Hiroyuki,Tatewaki Masamitsu,Fukushima Yasutsugu,Sugiyama Kumiya,Fukuda Takeshi
Dokkyo journal of medical sciences 39(3), 161-172, 2012-10-25
… However, their individual roles in idiopathic interstitial pneumonitis (IIP) and inthe other types of interstitial pneumonitis (IP), including collagen vascular disease associated interstitialpneumonitis (CVD-IP), remain unknown. …
NAID 110009493151

Epithelial-Mesenchymal Transition in Chronic Hypersensitivity Pneumonitis

Yasui Makito,Miyazaki Yasunari,Mitaka Keiko,Ishizuka Masahiro,Unoura Koji,Tamaoka Meiyo,Sumi Yuki,Inase Naohiko
Journal of medical and dental sciences 59(1), 29-41, 2012-03
… Chronic hypersensitivity pneumonitis (HP) causes progressive and irreversible pulmonary fibrosis, a disease also observed in conjunction with idiopathic pulmonary fibrosis (IPF). … In human, EMT cells in the AECs were significantly more prevalent in lungs specimens from patients with usual interstitial pneumonia pattern than in specimens from patients with nonspecific interstitial pneumonia pattern at the moderate stage of fibrosis. …
NAID 110008904368