WordNet

a substance that exerts some force or effect
a businessman who buys or sells for another in exchange for a commission (同)factor, broker
any agent or representative of a federal agency or bureau (同)federal agent
a representative who acts on behalf of other persons or organizations
an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
how long something has existed; "it was replaced because of its age"
a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
begin to seem older; get older; "The death of his wife caused him to age fast"
make older; "The death of his child aged him tremendously"
acting to increase the excretion of uric acid in the urine

PrepTutorEJDIC

『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる

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The potential drug-drug interactions of ginkgolide B mediated by renal transporters.

Qiu Z1, Wang L, Dai Y, Ren W, Jiang W, Chen X, Li N.
Phytotherapy research : PTR.Phytother Res.2015 May;29(5):662-7. doi: 10.1002/ptr.5294. Epub 2015 Jan 15.
Ginkgolide B (GB) is a selective and strong antagonist of platelet-activating factor with great benefits in CNS diseases treatment. The renal excretion constitutes the predominant secretory pathway of GB. Here, we investigated the potential role of renal drug transporters in GB urinary excretion. Th
PMID 25589475

The molecular insight into the antihyperuricemic and renoprotective effect of Shuang Qi gout capsule in mice.

Kodithuwakku ND1, Feng YD2, Zhang YY1, Pan M3, Fang WR4, Li YM5.
Journal of ethnopharmacology.J Ethnopharmacol.2015 Apr 2;163:278-89. doi: 10.1016/j.jep.2015.01.013. Epub 2015 Jan 19.
ETHNOPHARMACOLOGICAL RELEVANCE: Shuang-Qi gout capsule, a traditional Chinese medicine prescription, has been used in the treatment of, gout arthritis, arthralgia and inflammation. Since renal urate overload associated with severe disability including gout, elimination of excess renal uric acid is h
PMID 25614106

The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.

Itahana Y1, Han R1, Barbier S2, Lei Z3, Rozen S3, Itahana K1.
Oncogene.Oncogene.2015 Apr 2;34(14):1799-810. doi: 10.1038/onc.2014.119. Epub 2014 May 26.
Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular metabolism. One example of this is an anti
PMID 24858040