4型サイクリックヌクレオチドホスホジエステラーゼ
- 関
- phosphodiesterase 4
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- of a compound having atoms arranged in a ring structure
- recurring in cycles (同)cyclical
- conforming to the Carnot cycle
- forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
- marked by repeated cycles
- a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) (同)base
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
UpToDate Contents
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English Journal
- The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).
- Xie M, Blackman B, Scheitrum C, Mika D, Blanchard E, Lei T, Conti M, Richter W.
- The Biochemical journal.Biochem J.2014 May 1;459(3):539-50. doi: 10.1042/BJ20131681.
- PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed UCRs (upstream conserved regions). We have shown previously that PDE4D2, a short variant, is a monomer, whereas PDE4D3, a long variant, is a dim
- PMID 24555506
- Apremilast: first global approval.
- Poole RM1, Ballantyne AD.
- Drugs.Drugs.2014 May;74(7):825-37. doi: 10.1007/s40265-014-0218-4.
- Apremilast (Otezla(®)), an oral small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4), is under development with Celgene Corporation for the treatment of psoriatic arthritis, psoriasis, ankylosing spondylitis, Behçet's syndrome, atopic dermatitis, and rheumatoid arthritis.
- PMID 24797159
- Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation.
- Chaar V1, Laurance S, Lapoumeroulie C, Cochet S, De Grandis M, Colin Y, Elion J, Le Van Kim C, El Nemer W.
- The Journal of biological chemistry.J Biol Chem.2014 Apr 18;289(16):11512-21. doi: 10.1074/jbc.M113.506121. Epub 2014 Mar 10.
- Vaso-occlusive crises are the main acute complication in sickle cell disease. They are initiated by abnormal adhesion of circulating blood cells to vascular endothelium of the microcirculation. Several interactions involving an intricate network of adhesion molecules have been described between sick
- PMID 24616094
Japanese Journal
- Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex
- Takasaki Chihiro,Yamasaki Miwako,Uchigashima Motokazu,Konno Kohtarou,Yanagawa Yuchio,Watanabe Masahiko
- European Journal of Neuroscience 32(8), 1326-1336, 2010-10
- … In this study, we identified perineuronal oligodendrocytes as 2',3'-cyclic nucleotide 3'-phosphodiesterase(CNP)-positive cells attaching to neuronal perikarya immunostained for microtubule-associated protein 2, and examined their cytochemical and cytological properties in the mouse cerebral cortex. …
- NAID 120003370661
- Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery
- KANEDA Takeharu,KUBOTA Takashi,FUJIMOTO Kenji,URAKAWA Norimoto,NAKAJYO Shinjiro,SHIMIZU Kazumasa
- Journal of smooth muscle research = 日本平滑筋学会機関誌 46(1), 17-29, 2010-02-01
- … The effects of various selective phosphodiesterase (PDE) inhibitors on muscle contractility and cyclic nucleotide content in the porcine coronary artery were investigated. …
- NAID 10026187112
- Effects of Varioius Selective Phosphodiesterase Inhibitors on Relaxation and Cyclic Nucleotide Contents in Porcine Iris Sphincter
- Yogo Takuya,Kaneda Takeharu,Nezu Yoshinori [他],HARADA Yasuji,HARA Yasushi,TAGAWA Masahiro,URAKAWA Norimoto,SHIMIZU Kazumasa
- Journal of Veterinary Medical Science 71(11), 1449-1453, 2009
- … The effects of various selective phosphodiesterase (PDE) inhibitors on muscle contractility and cyclic nucleotide contents in porcine iris sphincter were investigated. …
- NAID 130000134316
Related Links
- 1. J Immunol. 2015 Jan 1;194(1):101-12. Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. Tan Y(1), Watkins AA(2), Freeman ...
- 1. PLoS One. 2012;7(1):e28899. doi: 10.1371/journal.pone.0028899. Epub 2012 Jan 11. Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
★リンクテーブル★
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ホスホジエステラーゼ4
- 関
- PDE4、type 4 cyclic nucleotide phosphodiesterase
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- 英
- type 4 cyclic nucleotide phosphodiesterase
- 関
- ホスホジエステラーゼ4
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- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
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- 関
- annular、circular、cyclical、cyclicity、cyclo、periodic、periodicity
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- 関
- form、mode、pattern、type
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ホスホジエステラーゼ PDE