Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/05 21:16:40」(JST)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia.

Paspalas CD, Wang M, Arnsten AF.SourceDepartment of Neurobiology, School of Medicine, Yale University, New Haven, CT 06510, USA.
Cerebral cortex (New York, N.Y. : 1991).Cereb Cortex.2013 Jul;23(7):1643-54. doi: 10.1093/cercor/bhs152. Epub 2012 Jun 12.
Schizophrenia associates with impaired prefrontal cortical (PFC) function and alterations in cyclic AMP (cAMP) signaling pathways. These include genetic insults to disrupted-in-schizophrenia (DISC1) and phosphodiesterases (PDE4s) regulating cAMP hydrolysis, and increased dopamine D1 receptor (D1R) e
PMID 22693343

Treatment of spondyloarthropathy: the potential for agents other than TNF inhibitors.

Her M, Kavanaugh A.SourceaDivision of Rheumatology, Pusan Paik Hospital, Inje University, Busan, South Korea bDivision of Rheumatology, Allergy, and Immunology, The University of California, San Diego, California, USA.
Current opinion in rheumatology.Curr Opin Rheumatol.2013 Jul;25(4):455-9. doi: 10.1097/BOR.0b013e3283620177.
PURPOSE OF REVIEW: Inhibitors of tumor necrosis factor (TNF) have demonstrated dramatic clinical efficacy in patients with spondyloarthropathy (SpA). However, not all patients respond, and some patients who initially improve, subsequently lose response. Therefore, there is still an unmet clinical ne
PMID 23680779

Inhibitory effects of hesperetin derivatives on guinea pig phosphodiesterases and Their ratios between high- and low-affinity rolipram binding.

Hsu HT, Wang WH, Han CY, Chen CN, Chen CM, Ko WC.SourceDepartment of Otolaryngology, Taipei Medical University Hospital, Taipei.
Journal of pharmaceutical sciences.J Pharm Sci.2013 Jul;102(7):2120-7. doi: 10.1002/jps.23591. Epub 2013 May 10.
The phosphodiesterase (PDE)4 molecule exists as two distinct conformers, PDE4H and PDE4L , which have high and low affinities, respectively, for the selective PDE4 inhibitor, rolipram. The inhibition of PDE4H and PDE4L is associated with adverse responses, such as nausea, vomiting, and gastric hyper
PMID 23666855