triple response of Lewis

膨疹・紅斑反応。ルイスの三重反応

WordNet

1. cause to stumble; "The questions on the test tripped him up" (同)trip_up
2. a hallucinatory experience induced by drugs; "an acid trip"
3. an unintentional but embarrassing blunder; "he recited the whole poem without a single trip"; "he arranged his robes to avoid a trip-up later"; "confusion caused his unfortunate misstep" (同)trip-up, stumble, misstep
4. a journey for some purpose (usually including the return); "he took a trip to the shopping center"
5. a light or nimble tread; "he heard the trip of womens feet overhead"
6. an exciting or stimulating experience (同)head trip
7. put in motion or move to act; "trigger a reaction"; "actuate the circuits" (同)actuate, trigger, activate, set_off, spark off, spark, trigger off, touch off
8. get high, stoned, or drugged; "He trips every weekend" (同)trip out, turn_on, get_off
9. English critic and novelist; author of theological works and of books for children (1898-1963) (同)C. S. Lewis, Clive Staples Lewis
10. United States athlete who won gold medals at the Olympics for his skill in sprinting and jumping (born in 1961) (同)Carl Lewis, Frederick Carleton Lewis
11. United States rock star singer and pianist (born in 1935) (同)Jerry Lee Lewis
12. United States labor leader who was president of the United Mine Workers of America from 1920 to 1960 and president of the Congress of Industrial Organizations from 1935 to 1940 (1880-1969) (同)John L. Lewis, John Llewelly Lewis
13. United States explorer and soldier who lead led an expedition from St. Louis to the mouth of the Columbia River (1774-1809) (同)Meriwether Lewis
14. United States novelist who satirized middle-class America in his novel Main Street (1885-1951) (同)Sinclair Lewis, Harry Sinclair Lewis
15. a result; "this situation developed in response to events in Africa"
16. a phrase recited or sung by the congregation following a versicle by the priest or minister
17. the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
18. hit a three-base hit
19. increase threefold; "Triple your income!" (同)treble
20. a base hit at which the batter stops safely at third base (同)three-base hit, three-bagger
21. a quantity that is three times as great as another

PrepTutorEJDIC

1. (一般に)『旅行』,旅 / (用件での)出張,通勤 / つまずき,踏みはずし / 過ち,失策 / (機械の)掛けはずし装置 / 《俗》(麻薬の)陶酔感(幻覚症状)の間 / (…に)『つまずく』,よろめく《+over(on)+名》 / (…を)間違える,誤る,しくじる《+over(on)+名》 / 《副詞[句]を伴って》軽快な足どりで歩く / 《俗》(麻薬で) 幻覚症状に陥る《+out》 / …‘を'『つまずかせる』《+名+up,+up+名》 / 〈人〉‘を'失敗させる,しくじらせる;〈人〉‘の'揚げ足を取る,あら捜しをする《+名+up,+up+名》 / 〈止め金・クラッチなど〉‘を'急にはずす,はずして作動させる
2. 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
3. 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
4. 3倍の / 3重の,3部から成る / 3倍の数(量) / (野球で)三塁打 / …‘を'3倍(3重)にする / 3倍(3重)になる / (野球で)三塁打を打つ

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/17 05:24:00」(JST)

wiki en

[Wiki en表示]

The triple response of Lewis is a cutaneous response that occurs from firm stroking of the skin, which produces an initial red line, followed by a flare around that line, and then finally a wheal.

The triple response of Lewis is due to the release of histamine.

Histamine, or 2-(imidazol-4-yl)ethanamine, is a dibasic vasoactive amine that is located in most body tissues but is highly concentrated in the lungs, skin, and gastrointestinal tract. Histamine is derived from the decarboxylation of the aminoacid histidine, a reaction catalyzed by the enzyme L-histidine decarboxylase. Histamine is a small molecule, stored as granules in mast cells and basophils.

Mast cells and basophils are the effector cells involved in the immediate hypersensitivity response. Found in tissues throughout the body, they are particularly associated with blood vessels and nerves and are in proximity to surfaces that border the external environment.

Explanation:

Injected intradermally histamine elicits the triple response consisting of:

1. Red spot: due to capillary dilatation
2. Flare: redness in the surrounding area due to arteriolar dilatation mediated by axon reflex.
3. Wheal: due to exudation of fluid from capillaries and venules

Hunting response of Lewis

The underlying pathophysiology of frostbite is a combination of freezing, vascular insufficiency (constriction and occlusion) and damage due to inflammatory mediators. As extremities cool, the ‘hunting response of Lewis’ (alternating vasoconstriction and vasodilation) occurs, ending with vasoconstriction.

See also

• Skin disease
• List of cutaneous conditions

References

UpToDate Contents

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• 3. ヘリコバクターピロリ感染の病態生理およびそれへの免疫応答 pathophysiology of and immune response to helicobacter pylori infection
• 4. 初回の非生物学的DMARD療法に耐性を示す成人における関節リウマチの治療 treatment of rheumatoid arthritis in adults resistant to initial nonbiologic dmard therapy
• 5. 赤血球抗原および抗体 red blood cell antigens and antibodies

English Journal

• Polypharmacy and comorbidity are associated with a lower early virologic response in hepatitis C patients treated with first generation protease inhibitor triple therapy: a preliminary analysis.

• Juneja M, Euliano R, Satoskar R, Lewis JH.SourceDepartment of Medicine, Medstar Georgetown University Hospital, 3800 Reservoir Road, NW, G3041 Gorman Bldg, 3rd floor, Washington, DC, 20007-2113, USA, Manie.Juneja@gunet.georgetown.edu.
• Digestive diseases and sciences.Dig Dis Sci.2013 Nov;58(11):3348-58. doi: 10.1007/s10620-013-2812-9. Epub 2013 Aug 8.
• BACKGROUND AND AIMS: The protease inhibitors (PIs) boceprevir and telaprevir are currently standard treatment as part of triple therapy regimens (TTx) for chronic HCV genotype 1 (GT1) patients. In this preliminary analysis, we have compared demographic variables, polypharmacy, and Charlson's comorbi
• PMID 23925819

• A Randomized Trial of Vitamin D3 Supplementation in Children: Dose-Response Effects on Vitamin D Metabolites and Calcium Absorption.

• Lewis RD, Laing EM, Hill Gallant KM, Hall DB, McCabe GP, Hausman DB, Martin BR, Warden SJ, Peacock M, Weaver CM.SourceThe University of Georgia (R.D.L., E.M.L., D.B.Hal. D.B.Hau.), Athens, Georgia 30602; Purdue University (K.M.H.G., G.P.M., B.R.M., C.M.W.), West Lafayette, Indiana 47907; and Indiana University (K.M.H.G., S.J.W., M.P.), Indianapolis, Indiana 42602.
• The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2013 Oct 3. [Epub ahead of print]
• Context:Changes in serum vitamin D metabolites and calcium absorption with varying doses of oral vitamin D3 in healthy children are unknown.Objective:Our objective was to examine the dose-response effects of supplemental vitamin D3 on serum vitamin D metabolites and calcium absorption in children li
• PMID 24092833

• A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models.

• Zhang X, Claerhout S, Prat A, Dobrolecki LE, Petrovic I, Lai Q, Landis MD, Wiechmann L, Schiff R, Giuliano M, Wong H, Fuqua SW, Contreras A, Gutierrez C, Huang J, Mao S, Pavlick AC, Froehlich AM, Wu MF, Tsimelzon A, Hilsenbeck SG, Chen ES, Zuloaga P, Shaw CA, Rimawi MF, Perou CM, Mills GB, Chang JC, Lewis MT.SourceLester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology, Pathology, and Molecular and Human Genetics, Baylor College of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• Cancer research.Cancer Res.2013 Aug 1;73(15):4885-97. doi: 10.1158/0008-5472.CAN-12-4081. Epub 2013 Jun 4.
• Breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. To overcome these limitations, we propagated a cohort of human breast tumors grown in the epithelium-
• PMID 23737486

Japanese Journal

• かゆい

• 小池 通夫
• 日本小児皮膚科学会雑誌 = Journal of
• NAID 10009421832

• 癩病変部の皮膚反応に関する研究　第1篇　Histamine皮内反応

• 藤田 恵一
• 日本皮膚科学会雑誌 69(9), 1305, 1959
• … 皮膚に刺戟が與えられた場合の局所血管反應の1つの形態にLewisの所謂triple responseがあり，これは次の3つの反應から成り立つている．即ち1）局所微細血管の擴張による発赤，2）局所血管透過性の増加による膨疹形成，及び3）血管の軸索反射性擴張による紅暈発生がこれである．Lewisは本反應が多様な機械的，化学的及び生理的の刺戟に対して何れも同様に発現 …
• NAID 130004685934

Related Links

• triple response (of Lewis) - definition of triple response (of ...

response /re·sponse/ (re-spons?) any action or change of condition evoked by a stimulus.respon?sive acute phase response a group of physiological processes occurring soon after the onset of infection, trauma, inflammatory ...

• triple response (of Lewis) - definition of triple response (of ...

Pronunciation of triple response (of Lewis). Translations of triple response (of Lewis). triple response (of Lewis) synonyms, triple response (of Lewis) antonyms. Information about triple response (of Lewis) in the free online English ...

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★リンクテーブル★

リンク元	「膨疹・紅斑反応」「ルイスの三重反応」
関連記事	「response」「triple」「Lewis」「trip」

「膨疹・紅斑反応」

　　[★]

英

wheal and flare response

同

ルイスの三重反応 triple response of Lewis

関

蕁麻疹、膨疹、紅斑

「ルイスの三重反応」

　　[★]

英

triple response of Lewis

関

膨疹・紅斑反応

「response」

　　[★]

• n.

• 返答、応答
• 反応、感応、反響。(刺激に対する)反応

　 　 　 　

「triple」

　　[★]

• 三重の、トリプル

関

triplex

　 　 　 　 　

「Lewis」

　　[★]

ルイス 　 　 　 　 　 　

「trip」

　　[★]