- 三重の
- 関
- triple
WordNet
- orach; saltbush (同)genus Atriplex
- hit a three-base hit
- increase threefold; "Triple your income!" (同)treble
- a base hit at which the batter stops safely at third base (同)three-base hit, three-bagger
- a quantity that is three times as great as another
PrepTutorEJDIC
- 3倍の,3重の / 《米》(各戸独立の)3階建てアパート / 〈U〉《しばしばT-》《英》《商標名》(自動車用の)3重ガラス
- 3倍の / 3重の,3部から成る / 3倍の数(量) / (野球で)三塁打 / …‘を'3倍(3重)にする / 3倍(3重)になる / (野球で)三塁打を打つ
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/28 20:44:38」(JST)
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- 1. 非結核性抗酸菌の微生物学 microbiology of nontuberculous mycobacteria
English Journal
- Spectroscopic studies on the binding interaction of novel 13-phenylalkyl analogs of the natural alkaloid berberine to nucleic acid triplexes.
- Bhowmik D1, Buzzetti F2, Fiorillo G2, Lombardi P2, Suresh Kumar G3.Author information 1Biophysical Chemistry Laboratory, Chemistry Division, CSIR - Indian Institute of Chemical Biology, Kolkata 700 032, India.2Naxopharma srl, Via G. Di Vittorio, 70, 20026 Novate Milanese (MI), Italy.3Biophysical Chemistry Laboratory, Chemistry Division, CSIR - Indian Institute of Chemical Biology, Kolkata 700 032, India. Electronic address: gskumar@iicb.res.in.AbstractIn this study we have characterized the capability of six 13-phenylalkyl analogs of berberine to stabilize nucleic acid triplex structures, poly(rA)⋅2poly(rU) and poly(dA)⋅2poly(dT). Berberine analogs bind to the RNA and DNA triplexes non-cooperatively. As the chain length of the substitution increased beyond CH2, the affinity enhanced up to critical length of (CH2)4, there after which the binding affinity decreased for both the triplexes. A remarkably stronger intercalative binding of the analogs compared to berberine to the triplexes was confirmed from ferrocyanide fluorescence quenching, fluorescence polarization and viscosity results. Circular dichroism results had indicated strong conformational changes in the triplexes on binding of the analogs. The analogs enhanced the stability of the Hoogsteen base paired third strand of both the triplexes while no significant change in the high-temperature duplex-to-single strand transitions was observed. Energetics of the interaction revealed that as the alkyl chain length increased, the binding was more entropy driven. This study demonstrates that phenylalkyl substitution at the 13-position of berberine increased the triplex binding affinity of berberine but a threshold length of the side chain is critical for the strong intercalative binding to occur.
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2014 Feb 24;120:257-64. doi: 10.1016/j.saa.2013.09.081. Epub 2013 Oct 7.
- In this study we have characterized the capability of six 13-phenylalkyl analogs of berberine to stabilize nucleic acid triplex structures, poly(rA)⋅2poly(rU) and poly(dA)⋅2poly(dT). Berberine analogs bind to the RNA and DNA triplexes non-cooperatively. As the chain length of the substitution in
- PMID 24184628
- Folding and Unfolding Pathways of the Human Telomeric G-Quadruplex.
- Gray RD1, Trent JO1, Chaires JB2.Author information 1James Graham Brown Cancer Center, University of Louisville, Louisville, KY USA 40202.2James Graham Brown Cancer Center, University of Louisville, Louisville, KY USA 40202. Electronic address: jchaires@louisville.edu.AbstractSequence analogues of human telomeric DNA such as d[AGGG(TTAGGG)3] (Tel22) fold into monomeric quadruplex structures in the presence of a suitable cation. To investigate the pathway for unimolecular quadruplex formation, we monitored the kinetics of K+-induced folding of Tel22 by circular dichroism (CD), intrinsic 2-aminopurine fluorescence, and fluorescence resonance energy transfer (FRET). The results are consistent with a four-step pathway U ↔ I1 ↔ I2 ↔ I3 ↔ F where U and F represent unfolded and folded conformational ensembles, and I1, I2, and I3 are intermediates. Previous kinetic studies have shown that I1 is formed in a rapid pre-equilibrium and may consist of an ensemble of "prefolded" hairpin structures brought about by cation-induced electrostatic collapse of the DNA. The current study shows that I1 converts to I2 with a relaxation time τ1=0.1s at 25°C in 25mM KCl. The CD spectrum of I2 is characteristic of an antiparallel quadruplex that could form as a result of intra-molecular fold-over of the I1 hairpins. I3 is relatively slowly formed (τ2≈3700s) and has CD and FRET properties consistent with those expected of a triplex structure as previously observed in equilibrium melting studies. I3 converts to F with τ3≈750s. Identical pathways with different kinetic constants involving a rapidly formed antiparallel intermediate were observed with oligonucleotides forming mixed parallel/antiparallel hybrid-1 and hybrid-2 topologies (e.g. d[TTGGG(TTAGGG)3A and d[TAGGG(TTAGGG)3TT]). Aspects of the kinetics of unfolding were also monitored by the spectroscopic methods listed above and by time-resolved fluorescence lifetime measurements using a complementary strand trap assay. These experiments reveal a slow, rate-limiting step along the unfolding pathway.
- Journal of molecular biology.J Mol Biol.2014 Jan 30. pii: S0022-2836(14)00047-3. doi: 10.1016/j.jmb.2014.01.009. [Epub ahead of print]
- Sequence analogues of human telomeric DNA such as d[AGGG(TTAGGG)3] (Tel22) fold into monomeric quadruplex structures in the presence of a suitable cation. To investigate the pathway for unimolecular quadruplex formation, we monitored the kinetics of K+-induced folding of Tel22 by circular dichroism
- PMID 24487181
- Healing process of a novel zero-porosity vascular graft.
- Morota T, Takamoto S.Author information Department of Cardiothoracic Surgery, The University of Tokyo, Tokyo, Japan.AbstractOBJECTIVES: We report on a study of thoracic aortic replacement in a canine model in order to demonstrate experimentally the process of tissue healing facilitated by the uniquely structured Triplex® graft.
- Interactive cardiovascular and thoracic surgery.Interact Cardiovasc Thorac Surg.2014 Jan 27. [Epub ahead of print]
- OBJECTIVES: We report on a study of thoracic aortic replacement in a canine model in order to demonstrate experimentally the process of tissue healing facilitated by the uniquely structured Triplex® graft.METHODS: Twelve Triplex® grafts were used in this study with 12 collagen-coated vascular graf
- PMID 24473473
Japanese Journal
- BASE PAIR RECOGNITION ABILITY OF 2-(METHYLAMINO)PYRIMIDIN-4-YL NUCLEOBASE IN PARALLEL TRIPLEX DNA (Dedicated to Professor Isao Kuwajima on the occasion of his 77th birthday)
- Hari Yoshiyuki,Kashima Satoshi,Matsuda Yuya [他]
- Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 90(1), 432-441, 2015-01-01
- NAID 40020330349
- Construction of a linkage map based on retrotransposon insertion polymorphisms in sweetpotato via high-throughput sequencing
- Monden Yuki,Hara Takuya,Okada Yoshihiro [他],Jahana Osamu,Kobayashi Akira,Tabuchi Hiroaki,Onaga Shoko,Tahara Makoto
- Breeding Science 65(2), 145-153, 2015
- … High-throughput sequencing and subsequent data analyses identified many Rtsp-1 retrotransposon insertion sites, and their allele dosages (simplex, duplex, triplex, or double-simplex) were determined based on segregation ratios in the mapping population. …
- NAID 130005068207
- Simultaneous Genotyping of Single-nucleotide Polymorphisms in Alcoholism-related Genes Using Duplex and Triplex Allele-specific PCR with Two-step Thermal Cycles
- SHIRASU Naoto,KUROKI Masahide
- Analytical Sciences 30(11), 1093-1096, 2014-11
- NAID 40020259720
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- 栄養補給の基本をしっかり押さえた「トリプルX」 自然をまるごと濃縮した理想の サプリメント、トリプルX。 選び抜かれた21種類のみずみずしい原料植物を閉じ込めた、 濃縮物は自然の力がみなぎっています。 基本のサプリメントとして、売り上げNo.1です。
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★リンクテーブル★
| リンク元 | 「三重」 |
| 拡張検索 | 「Atriplex属」「Atriplex」 |
| 関連記事 | 「triple」 |
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- 三重の、トリプル
- 関
- triplex