transferrin receptor

トランスフェリン受容体

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. a globulin in blood plasma that carries iron (同)beta_globulin, siderophilin

PrepTutorEJDIC

1. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/07 15:28:51」(JST)

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[Wiki en表示]

transferrin receptor (p90, CD71)
Identifiers
Symbol	TFRC
Alt. symbols	CD71, TFR1
Entrez	7037
HUGO	11763
OMIM	190010
RefSeq	NM_003234
UniProt	P02786
Other data
Locus	Chr. 3 q29

transferrin receptor 2
Identifiers
Symbol	TFR2
Alt. symbols	HFE3, TFRC2
Entrez	7036
HUGO	11762
OMIM	604720
RefSeq	NM_003227
UniProt	Q9UP52
Other data
Locus	Chr. 7 q22

Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis.

Regulation

Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis.

TfR production in the cell is regulated according to iron levels by iron response/regulatory element binding protein (IRE-BP), also referred to as Iron Regulatory Protein (IRP). This protein binds to the hairpin like structure (IRE) that is in the 3' UTR of the TfR receptor. Once binding occurs, degradation of mRNA of IRE is inhibited.

See also

• TFR2
• TFRC

References

Further reading

• Testa U, Kühn L, Petrini M, Quaranta MT, Pelosi E, Peschle C (July 1991). "Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages". J. Biol. Chem. 266 (21): 13925–30. PMID 1856222. 
• Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML (November 2006). "The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer". Clin. Immunol. 121 (2): 144–58. doi:10.1016/j.clim.2006.06.010. PMID 16904380. ; Figure 3: Cellular uptake of iron through the Tf system via receptor-mediated endocytosis.
• Daniels TR, Delgado T, Helguera G, Penichet ML (November 2006). "The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells". Clin. Immunol. 121 (2): 159–76. doi:10.1016/j.clim.2006.06.006. PMID 16920030. 

External links

• Transferrin receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
• Okam M (2001-01-29). "Transerrin and Iron Transport Physiology". Information Center for Sickle Cell and Thalassemic Disorders. Brigham and Women's Hospital and Harvard Medical School. Retrieved 2010-12-19. 

UpToDate Contents

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• 1. 鉄欠乏性貧血の原因および診断 causes and diagnosis of anemia due to iron deficiency
• 2. 鉄のバランス調節 regulation of iron balance
• 3. 慢性疾患の貧血（慢性炎症時の貧血） anemia of chronic disease anemia of chronic inflammation
• 4. 遺伝性ヘモクロマトーシスの遺伝学 genetics of hereditary hemochromatosis
• 5. 高齢の成人における貧血 anemia in the older adult

English Journal

• A Convenient Method For hTfR1 Inclusion Body Purification.

• Shao M1, Peng ZX, Shi CY, Tang R, Manzo LM, Liu Y.
• Preparative biochemistry & biotechnology.Prep Biochem Biotechnol.2015 Nov 17;45(8):743-753.
• Human transferrin receptor, referred as hTfR1, is ubiquitously expressed at low levels in most normal human tissues; however, the expression level of hTfR1 at the blood-brain barrier (BBB) and in tumor tissues is relatively higher. hTfR1 is a type II homodimeric transmembrane protein. The extracellu
• PMID 25207990

• The Megalobrama amblycephala transferrin and transferrin receptor genes: Molecular cloning, characterization and expression during early development and after Aeromonas hydrophila infection.

• Ding Z1, Zhao X1, Su L1, Zhou F1, Chen N1, Wu J1, Fu X1, Wu F1, Wang W2, Liu H3.
• Developmental and comparative immunology.Dev Comp Immunol.2015 Apr;49(2):290-7. doi: 10.1016/j.dci.2014.12.010. Epub 2014 Dec 18.
• Both transferrin (TF) and transferrin receptor (TFR) play vital roles in iron homeostasis, which is essential for cellular growth and survival. Besides, TF and TFR are also reported to be involved in immune response against bacterial infection. In the present study, we cloned and characterized the T
• PMID 25530094

• Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation.

• Shi ZH1, Shi FF, Wang YQ, Sheftel AD, Nie G, Zhao YS, You LH, Gou YJ, Duan XL, Zhao BL, Xu HM, Li CY, Chang YZ.
• Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2015 Mar;72(5):983-97. doi: 10.1007/s00018-014-1730-0. Epub 2014 Sep 12.
• Mitochondrial ferritin (FtMt) has a significant effect on the regulation of cytosolic and mitochondrial iron levels. However, because of the deficiency of iron regulatory elements (IRE) in FtMt's gene sequence, the exact function of FtMt remains unclear. In the present study, we found that FtMt dram
• PMID 25213357

Japanese Journal

• The A Allele of the -576G>A Polymorphism of the Transferrin Gene Is Associated with the Increased Risk of Age-Related Macular Degeneration in Smokers

• WYSOKINSKI Daniel,SZAFLIK Jerzy,SKLODOWSKA Anna,KOLODZIEJSKA Urszula,DORECKA Mariola,ROMANIUK Dorota,WOZNIAK Katarzyna,BLASIAK Janusz,SZAFLIK Jacek Pawel
• Tohoku journal of experimental medicine 223(4), 253-261, 2011-04-01
• NAID 10027990523

• A Novel Hybrid Peptide That Binds Transferrin Receptor and Induces Rapid Permeation of Cancer Cell Membrane

• KAWAMOTO Megumi,HORIBE Tomohisa,KOHNO Masayuki,KAWAKAMI Koji
• Peptide science : proceedings of the ... Japanese Peptide Symposium 2010, 241, 2011-03-01
• NAID 10028238014

Related Links

• TFRC transferrin receptor [Homo sapiens (human)]

Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. ... Gene ID: 7037, updated on 19-Jan-2014 Summary Other designations transferrin receptor (p90, CD71), transferrin receptor ...

• Transferrinとは - goo Wikipedia (ウィキペディア)

Transport mechanism [edit] When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell (e.g., to erythroid precursors in the bone marrow), it binds to it and, as a consequence, is transported into ...

Related Pictures

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★リンクテーブル★

リンク元	「トランスフェリン受容体」「TfR」
拡張検索	「bacterial transferrin receptor complex」
関連記事	「transferrin」

「トランスフェリン受容体」

　　[★]

英

transferrin receptor, TfR

同

トランスフェリンレセプター

関

トランスフェリン、鉄

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トランスフェリンレセプター : 約 4,290 件
トランスフェリン受容体 : 約 6,780 件

概念

• 赤芽球などヘム合成の盛んな細胞に発現

判別

高値

• 鉄欠乏性貧血
• エリスロポエチン高値

低値

• 慢性疾患に伴う二次性貧血 ACD

「TfR」

　　[★] トランスフェリン受容体、トランスフェリンレセプター、transferrin receptor

「bacterial transferrin receptor complex」

　　[★]

• 細菌トランスフェリン受容体複合体

「transferrin」

　　[★] トランスフェリン