tolerability

耐用性、耐容性、認容性、許容性、許容度

関

acceptability、acceptance、allowance、permissivity、tolerance、tolerant

WordNet

1. the act of tolerating something
2. the power or capacity of an organism to tolerate unfavorable environmental conditions
3. willingness to recognize and respect the beliefs or practices of others
4. a permissible difference; allowing some freedom to move within limits (同)leeway, margin, tolerance
5. the act of allowing; "He objected to the allowance of smoking in the dining room"
6. an amount added or deducted on the basis of qualifying circumstances; "an allowance for profit" (同)adjustment
7. a sum granted as reimbursement for expenses
8. an amount allowed or granted (as during a given period); "travel allowance"; "my weekly allowance of two eggs"; "a childs allowance should not be too generous"
9. put on a fixed allowance, as of food
10. the act of taking something that is offered; "her acceptance of the gift encouraged him"; "he anticipated their acceptance of his offer"
11. banking: a time draft drawn on and accepted by a bank (同)banker''s acceptance
12. the state of being acceptable and accepted; "torn jeans received no acceptance at the country club"
13. (contract law) words signifying consent to the terms of an offer (thereby creating a contract)
14. showing respect for the rights or opinions or practices of others
15. showing the capacity for endurance; "injustice can make us tolerant and forgiving"; "a man patient of distractions" (同)patient of
16. able to tolerate environmental conditions or physiological stress; "the plant is tolerant of saltwater"; "these fish are quite tolerant as long as extremes of pH are avoided"; "the new hybrid is more resistant to drought" (同)resistant
17. satisfactoriness by virtue of conforming to approved standards (同)acceptableness

PrepTutorEJDIC

1. (自分と異なる他人の意見・行動などを許す)寛大,寛容・我慢（がまん）,忍耐力 / (薬品・毒物などに対する)耐性,抗毒性 / 公差,許容誤差
2. 『割り当て』;(定期的な)手当,こづかい / 値引き,割引き
3. 〈U〉受け取ること,認めること,受け入れられていること;同意 / 〈U〉(手形の)引受け;〈C〉引受済み手形
4. 寛大な,寛容な;(…に)寛大な《+of(to)+名》 / (薬品・毒物などの作用に)耐性がある,抵抗力のある
5. 受け入れられること,受容性

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/24 23:17:47」(JST)

wiki en

[Wiki en表示]

Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient. Tolerability of a particular drug can be discussed in a general sense, or it can be a quantifiable measurement as part of a clinical study. Usually, it is measured by the rate of "dropouts," or patients that forfeit participation in a study due to extreme adverse effects. Tolerability, however, is often relative to the severity of the medical condition a drug is designed to treat. For instance, cancer patients will generally tolerate an immense amount of pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache, will not.

As an example, tricyclic antidepressants (TCAs) are very poorly tolerated and often produce severe side effects including sedation, orthostatic hypotension, and anticholinergic effects, whereas newer antidepressants have far fewer adverse effects and are well tolerated.

See also

• Side effect

References

UpToDate Contents

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English Journal

• The efficacy and tolerability of pomalidomide in relapsed/refractory myeloma patients in a "real-world" study: the Royal Marsden Hospital experience.

• Sriskandarajah P1,2, Pawlyn C1,2, Mohammed K1, Dearden CE1, Davies FE1,3, Morgan GJ1,3, Boyd KD1, Kaiser MF1,2.
• Leukemia & lymphoma.Leuk Lymphoma.2017 Feb;58(2):494-497. Epub 2016 Jul 20.
• PMID 27439571

• A novel nanoparticles impregnated ocular insert for enhanced bioavailability to posterior segment of eye: In vitro, in vivo and stability studies.

• Rathod LV1, Kapadia R1, Sawant KK2.
• Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2017 Feb 1;71:529-540. doi: 10.1016/j.msec.2016.10.017. Epub 2016 Oct 15.
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• Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

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• Neuropharmacology.Neuropharmacology.2017 Feb;113(Pt A):206-216. doi: 10.1016/j.neuropharm.2016.10.013. Epub 2016 Oct 13.
• Although the sodium channel blocker, mexiletine, is the first choice drug in myotonia, some myotonic patients remain unsatisfied due to contraindications, lack of tolerability, or incomplete response. More therapeutic options are thus needed for myotonic patients, which require clinical trials based
• PMID 27743929

Japanese Journal

• 残遺型,多剤併用,多量投与,治療抵抗性又は高齢の統合失調症患者を対象にasenapine舌下錠を52週間投与した場合の安全性及び有効性を検討する第Ⅲ相試験(P06238試験)

• 臨床精神薬理 19(6), 771-787, 2016-06
• NAID 40020910138

• 統合失調症患者を対象にasenapine舌下錠を52週間投与した場合の安全性及び有効性を検討する第Ⅲ相延長投与試験(P06125試験)

• 臨床精神薬理 19(6), 753-770, 2016-06
• NAID 40020910114

• 治癒切除できたIA期小細胞肺癌の病理学的検討

• 肺癌 56(3), 205-209, 2016
• NAID 130005163241

Related Links

• tolerabilityの意味・用例｜英辞郎 on the WEB：アルク

tolerability 【名】耐性、耐容性、認容性、許容性、忍容性 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。

• safety and tolerability - 日本語翻訳 – Linguee辞書

"safety and tolerability" への豊富な翻訳例文 – 和英辞書と日本語翻訳サーチエンジン ... また、これまでと同様、 患者さんの安全性を最優先 に考え、ピオグリタゾンを含む全ての当社製品に 関 す る安全性と 忍容 性 の評価を継続する ...

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★リンクテーブル★

リンク元	「acceptance」「認容性」「許容度」「tolerant」「allowance」

「acceptance」

　　[★]

• n.

• 受諾、承認、受理、受け入れ、許容性、認容性

関

accept、acceptability、acknowledge、admission、approval、approve、authorization、tolerability、tolerant

　 　 　 　 　

「認容性」

　　[★]

英

tolerability、acceptability、acceptance、tolerant

関

受け入れ、寛容、寛容性、許容度、承認、受諾、耐性、耐容性、許容性、受理、耐用性

「許容度」

　　[★]

英

tolerance、tolerability、allowance、permissivity

関

寛容、寛容性、許容、耐性、耐容性、認容性、耐容能、許容性、トレランス、耐用性

「tolerant」

　　[★]

• 寛容性のある、認容性のある、耐性の、寛容な

関

acceptability、acceptance、permissiveness、resistance、resistant、tolerability、tolerance

　 　 　 　

「allowance」

　　[★]

• n.

• 許容、許容度

関

allow、permission、permissivity、permit、sanction、tolerability、tolerance、tolerate