甲状腺刺激ホルモン受容体
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- anterior pituitary hormone that stimulates the function of the thyroid gland (同)thyrotropic hormone, thyrotrophin, thyrotrophic hormone, thyroid-stimulating_hormone, TSH
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/20 21:53:24」(JST)
[Wiki en表示]
Not to be confused with Thyrotropin-releasing hormone or Thyrotropin-releasing hormone receptor.
| Thyroid stimulating hormone receptor |
Rendering based on PDB 1XUM. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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2XWT, 3G04
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| Identifiers |
| Symbols |
TSHR; CHNG1; LGR3; hTSHR-I |
| External IDs |
OMIM: 603372 MGI: 98849 HomoloGene: 315 IUPHAR: TSH receptor ChEMBL: 1963 GeneCards: TSHR Gene |
| Gene Ontology |
| Molecular function |
• thyroid-stimulating hormone receptor activity
• protein binding
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| Cellular component |
• plasma membrane
• integral to plasma membrane
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| Biological process |
• G-protein coupled receptor signaling pathway
• G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• cell-cell signaling
• positive regulation of cell proliferation
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
7253 |
22095 |
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| Ensembl |
ENSG00000165409 |
ENSMUSG00000020963 |
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| UniProt |
P16473 |
P47750 |
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| RefSeq (mRNA) |
NM_000369 |
NM_001113404 |
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| RefSeq (protein) |
NP_000360 |
NP_001106875 |
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| Location (UCSC) |
Chr 14:
81.42 – 81.61 Mb |
Chr 12:
91.4 – 91.54 Mb |
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| PubMed search |
[1] |
[2] |
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The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins[1] and is coupled to the Gs protein.[2]
It is primarily found on the surface of the thyroid epithelial cells.
Contents
- 1 Function
- 2 See also
- 3 References
- 4 Further reading
- 5 External links
Function[edit]
Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.
See also[edit]
References[edit]
- ^ Farid NR, Szkudlinski MW (2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707.
- ^ Calebiro D, Nikolaev VO, Lohse MJ (July 2010). "Imaging of persistent cAMP signaling by internalized G protein-coupled receptors". J. Mol. Endocrinol. 45 (1): 1–8. doi:10.1677/JME-10-0014. PMID 20378719.
Further reading[edit]
- Führer D, Wonerow P, Willgerodt H, Paschke R (1998). "Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.". J. Clin. Endocrinol. Metab. 82 (12): 4234–8. doi:10.1210/jc.82.12.4234. PMID 9398746.
- Farid NR, Kascur V, Balazs C (2000). "The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations.". Eur. J. Endocrinol. 143 (1): 25–30. doi:10.1530/eje.0.1430025. PMID 10870027.
- Szkudlinski MW, Fremont V, Ronin C, Weintraub BD (2002). "Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.". Physiol. Rev. 82 (2): 473–502. doi:10.1152/physrev.00031.2001. PMID 11917095.
- Tonacchera M, Vitti P, De Servi M, et al. (2004). "Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.". J. Endocrinol. Invest. 26 (2 Suppl): 2–6. PMID 12762632.
- Arturi F, Scarpelli D, Coco A, et al. (2004). "Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.". Thyroid 13 (4): 341–3. doi:10.1089/105072503321669811. PMID 12804102.
- Vaidya B, Campbell V, Tripp JH, et al. (2004). "Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.". Clin. Endocrinol. (Oxf) 60 (6): 711–8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335.
- Takeshita A, Nagayama Y, Fujiyama K, et al. (1992). "Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript.". Biochem. Biophys. Res. Commun. 188 (3): 1214–9. doi:10.1016/0006-291X(92)91360-3. PMID 1445355.
- Graves PN, Tomer Y, Davies TF (1992). "Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.". Biochem. Biophys. Res. Commun. 187 (2): 1135–43. doi:10.1016/0006-291X(92)91315-H. PMID 1530609.
- Loosfelt H, Pichon C, Jolivet A, et al. (1992). "Two-subunit structure of the human thyrotropin receptor". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3765–9. doi:10.1073/pnas.89.9.3765. PMC 525571. PMID 1570295.
- Nagayama Y, Russo D, Wadsworth HL, et al. (1991). "Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding". J. Biol. Chem. 266 (23): 14926–30. PMID 1651314.
- Murakami M, Mori M (1990). "Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease". Biochem. Biophys. Res. Commun. 171 (1): 512–8. doi:10.1016/0006-291X(90)91423-P. PMID 1697467.
- Heldin NE, Gustavsson B, Westermark K, Westermark B (1992). "A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism". J. Clin. Endocrinol. Metab. 73 (6): 1374–6. doi:10.1210/jcem-73-6-1374. PMID 1955520.
- Libert F, Passage E, Lefort A, et al. (1991). "Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization". Cytogenet. Cell Genet. 54 (1–2): 82–3. doi:10.1159/000132964. PMID 2249482.
- Frazier AL, Robbins LS, Stork PJ, et al. (1991). "Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing". Mol. Endocrinol. 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030.
- Misrahi M, Loosfelt H, Atger M, et al. (1990). "Cloning, sequencing and expression of human TSH receptor". Biochem. Biophys. Res. Commun. 166 (1): 394–403. doi:10.1016/0006-291X(90)91958-U. PMID 2302212.
- Nagayama Y, Kaufman KD, Seto P, Rapoport B (1990). "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor". Biochem. Biophys. Res. Commun. 165 (3): 1184–90. doi:10.1016/0006-291X(89)92727-7. PMID 2558651.
- Libert F, Lefort A, Gerard C, et al. (1990). "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies". Biochem. Biophys. Res. Commun. 165 (3): 1250–5. doi:10.1016/0006-291X(89)92736-8. PMID 2610690.
- Cuddihy RM, Bryant WP, Bahn RS (1996). "Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor". Thyroid 5 (4): 255–7. doi:10.1089/thy.1995.5.255. PMID 7488864.
- Bahn RS, Dutton CM, Heufelder AE, Sarkar G (1994). "A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy". J. Clin. Endocrinol. Metab. 78 (2): 256–60. doi:10.1210/jc.78.2.256. PMID 7508946.
- Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S (1995). "Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene". N. Engl. J. Med. 332 (3): 155–60. doi:10.1056/NEJM199501193320305. PMID 7528344.
External links[edit]
- "Glycoprotein Hormone Receptors: TSH". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Thyrotropin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
- GRIS: Glycoprotein-hormone Receptor Information System
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Cell surface receptor: G protein-coupled receptors
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Class A:
Rhodopsin like |
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| Class B: Secretin like |
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Orphan
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- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
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Other
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- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
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Class C: Metabotropic
glutamate / pheromone |
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Taste
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- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
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Other
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- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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Class F:
Frizzled / Smoothened |
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Frizzled
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- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
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Smoothened
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptide receptors
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| G protein-coupled receptor |
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Hormone receptors
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Hypothalamic
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CRH · FSH · LHRH · TRH · Somatostatin
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Pituitary
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Vasopressin (1A, 1B, 2) · Oxytocin · LHCG · TSH
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Other
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Atrial natriuretic factor (NPR3) · Calcitonin · Cholecystokinin (A, B) · VIP
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Opioid receptors
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Delta · Kappa · Mu · Nociceptin
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Other neuropeptide receptors
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Angiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · Neurotensin
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| Type I cytokine receptor |
GH · Prolactin
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| Enzyme-linked receptor |
Atrial natriuretic factor (NPR1, NPR2)
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| Other |
Sigma (1, 2)
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells.
- Carretero L1, Llavona P1, López-Hernández A1, Casado P2, Cutillas PR2, de la Peña P1, Barros F1, Domínguez P3.
- Cellular signalling.Cell Signal.2015 May 27;27(9):1720-1730. doi: 10.1016/j.cellsig.2015.05.014. [Epub ahead of print]
- The transduction pathway mediating the inhibitory effect that TRH exerts on r-ERG channels has been thoroughly studied in GH3 rat pituitary cells but some elements have yet to be discovered, including those involved in a phosphorylation event(s). Using a quantitative phosphoproteomic approach we stu
- PMID 26022182
- Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.
- Duncan Bassett JH1, van der Spek A2, Logan JG1, Gogakos A1, Chakraborty JB1, Murphy E1, van Zeijl C2, Down J3, Croucher PI3, Boyde A4, Boelen A2, Williams GR1.
- Endocrinology.Endocrinology.2015 May 27:en20141943. [Epub ahead of print]
- The ancestral glycoprotein hormone thyrostimulin is a heterodimer of unique GPA2 and GPB5 subunits with high affinity for the thyrotropin receptor (TSHR). Transgenic over-expression of GPB5 in mice results in cranial abnormalities, but the role of thyrostimulin in bone remains unknown. We hypothesiz
- PMID 26018249
- Skin fibrosis correlates with circulating thyrotropin levels in systemic sclerosis: translational association with Hashimoto's thyroiditis.
- Bagnato GL1, Roberts WN, Fiorenza A, Arcuri C, Certo R, Trimarchi F, Ruggeri RM, Bagnato GF.
- Endocrine.Endocrine.2015 May 21. [Epub ahead of print]
- Systemic sclerosis (SSc) is a connective tissue disease, characterized by cutaneous and multi-organ fibrosis, and vascular abnormalities. Skin thickening is a characteristic feature of SSc and resembles myxedematous skin. Our aim was to correlate the degree of skin involvement in SSc patients with s
- PMID 25994300
Japanese Journal
- 久能 芙美,岡田 洋右,新生 忠司,黒住 旭,田中 良哉
- 産業医科大学雑誌 37(1), 49-53, 2015-03-01
- … FT4)6.15ng/ml, 抗TSH受容体抗体(TSH receptor antibody; …
- NAID 110009924218
- A family of RTHβ with p.R316C mutation presenting occasional syndrome of inappropriate secretion of TSH
- Ueda Yohei,Tagami Tetsuya,Tamanaha Tamiko,Kakita Maiko,Tanase-Nakao Kanako,Nanba Kazutaka,Usui Takeshi,Naruse Mitsuhide,Shimatsu Akira
- Endocrine Journal 62(3), 251-260, 2015
- … The syndrome of inappropriate secretion of thyrotropin (SITSH) is a hallmark of resistance to thyroid hormone (RTH) due to mutations in the β isoform of the thyroid hormone receptor (TRβ). …
- NAID 130005060859
- 久能 芙美,岡田 洋右,新生 忠司 [他],黒住 旭,田中 良哉
- Journal of UOEH 37(1), 49-53, 2015
- … FT4） 6.15 ng/ml，抗TSH受容体抗体 （TSH receptor antibody; …
- NAID 130004923376
Related Links
- The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH ...
- Recommended first-line test for detection of thyrotropin receptor (TSHR) antibodies, and used in the following situations: -Differential diagnosis of etiology of thyrotoxicosis in patients with ambiguous clinical findings and/or contraindicated (eg, ...
Related Pictures
★リンクテーブル★
[★]
- 英
- thyroid-stimulating hormone receptor thyrotropin receptor TSH receptor TSH-R
- 関
- サイロトロピン受容体 thyrotropin receptor TR、TSH受容体、TSHレセプター、甲状腺刺激ホルモンレセプター、サイロトロピンレセプター
- 甲状腺刺激ホルモン TSH、甲状腺、下垂体前葉
[★]
- 関
- thyroid-stimulating hormone receptor、thyrotropin receptor
[★]
- 関
- thyrotropin receptor、TSH receptor
[★]
甲状腺刺激ホルモン受容体抗体
[★]
甲状腺刺激ホルモン