tensilon test

テンシロンテスト

WordNet

1. undergo a test; "She doesnt test well"
2. any standardized procedure for measuring sensitivity or memory or intelligence or aptitude or personality etc; "the test was standardized on a large sample of students" (同)mental test, mental testing, psychometric test
3. the act of undergoing testing; "he survived the great test of battle"; "candidates must compete in a trial of skill" (同)trial
4. the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial" (同)trial, run
5. a hard outer covering as of some amoebas and sea urchins
6. put to the test, as for its quality, or give experimental use to; "This approach has been tried with good results"; "Test this recipe" (同)prove, try, try out, examine, essay
7. achieve a certain score or rating on a test; "She tested high on the LSAT and was admitted to all the good law schools"
8. determine the presence or properties of (a substance)
9. show a certain characteristic when tested; "He tested positive for HIV"
10. an examination of the characteristics of something; "there are laboratories for commercial testing"; "it involved testing thousands of children for smallpox"
11. the act of subjecting to experimental test in order to determine how well something works; "they agreed to end the testing of atomic weapons"
12. tested and proved useful or correct; "a tested method" (同)tried, well-tried
13. tested and proved to be reliable (同)time-tested, tried, tried and true

PrepTutorEJDIC

1. (人の能力などの)『試験』,考査,テスト / (物事の)『試験』,検済,試錬,実験《+of+名》 / 化学分析;試薬 / =test match / …‘を'『試験する』,検査する / …‘を'化学分析する / (…の)試験を受ける,試験をする《+for+名》
2. testis の複数形

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/09 21:48:47」(JST)

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Edrophonium

Systematic (IUPAC) name
N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium
Clinical data
Trade names	Tensilon
AHFS/Drugs.com	FDA Professional Drug Information
Identifiers
CAS Registry Number	116-38-1 Y
ATC code	None
PubChem	CID: 8307
DrugBank	DB01010 Y
ChemSpider	8006 Y
UNII	QO611KSM5P Y
KEGG	D00994 Y
ChEBI	CHEBI:4759 Y
ChEMBL	CHEMBL1128 Y
Chemical data
Formula	C10H16NO+
Molecular mass	166.24 g/mol
SMILES [Cl-].Oc1cccc(c1)[N+](C)(CC)C
InChI InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H Y Key:BXKDSDJJOVIHMX-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Edrophonium is a readily reversible acetylcholinesterase inhibitor. It prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction. It is sold under the trade names Tensilon and Enlon (according to FDA Orange Book).

Clinical uses

Edrophonium (by the so-called Tensilon test) is used to differentiate myasthenia gravis from cholinergic crisis and Lambert-Eaton myasthenic syndrome. In myasthenia gravis, the body produces autoantibodies which block, inhibit or destroy nicotinic acetylcholine receptors in the neuromuscular junction. Edrophonium—an effective acetylcholinesterase inhibitor—will reduce the muscle weakness by blocking the enzymatic effect of acetylcholinesterase enzymes, prolonging the presence of acetylcholine in the synaptic cleft. It binds to a Serine-103 allosteric site, while pyridostigmine and neostigmine bind to the AchE active site for their inhibitory effects. In a cholinergic crisis, where a person has too much neuromuscular stimulation, edrophonium will make the muscle weakness worse by inducing a depolarizing block.

Lambert-Eaton myasthenic syndrome (LEMS), is similar to myasthenia gravis in that it is an autoimmune disease. However, in LEMS the neuron is unable to release enough acetylcholine for normal muscle function due to autoantibodies attacking P/Q-type calcium channel that are necessary for acetylcholine release. This means there is insufficient calcium ion influx into presynaptic terminal resulting in reduced exocytosis of acetylcholine containing vesicles. Consequently, there will typically be not as much increase in muscle strength observed after edrophonium injection, if any with LEMS.

The drug may also be used for postoperative decurarization.

Chemistry

Edrophonium, ethyl-(3-hydroxyphenyl)dimethylammonium chloride, is made by reacting 3-dimethylaminophenol with ethyl bromide, which forms ethyl(3-hydroxyphenyl)dimethylammonium bromide, the bromine atom of which is replaced with a chlorine atom by reacting it with silver chloride, giving edrophonium.

• J.A. Aeschlimann, A. Stempel, U.S. Patent 2,647,924 (1953).

Pharmacokinetics

The drug has a brief duration of action, about 10–30 mins.

Sources

1. Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W. B. Saunders Company. ISBN 0-7216-7757-6
2. Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

Reference

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 重症筋無力症の診断 diagnosis of myasthenia gravis
• 2. 眼筋型重症筋無力症 ocular myasthenia gravis
• 3. 重症筋無力症の鑑別診断 differential diagnosis of myasthenia gravis
• 4. 世界各地における蛇咬傷：臨床症状および診断 snakebites worldwide clinical manifestations and diagnosis
• 5. 世界中でのヘビ咬傷：マネージメント snakebites worldwide management

English Journal

• PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome.

• Régal L1, Shen XM, Selcen D, Verhille C, Meulemans S, Creemers JW, Engel AG.
• Neurology.Neurology.2014 Apr 8;82(14):1254-60. doi: 10.1212/WNL.0000000000000295. Epub 2014 Mar 7.
• OBJECTIVE: To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy.METHODS: We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated
• PMID 24610330

• In vivo and in vitro effects of neostigmine on gastrointestinal tract motility of horses.

• Nieto JE1, Morales B, Yamout SZ, Stanley SD, Harmon FA, Snyder JR.
• American journal of veterinary research.Am J Vet Res.2013 Apr;74(4):579-88. doi: 10.2460/ajvr.74.4.579.
• OBJECTIVE: To determine the response to neostigmine of the contractile activity of the jejunum and pelvic flexure and the effects of a continuous rate infusion (CRI) of neostigmine in horses.ANIMALS: 7 adult horses and tissue from 12 adult horses.PROCEDURES: A CRI of neostigmine (0.008 mg/kg/h) or p
• PMID 23531066

• Abnormal sympathetic hyper-reactivity in patients with myasthenia gravis: a prospective study.

• Shukla G1, Gupta S, Goyal V, Singh S, Srivastava A, Behari M.
• Clinical neurology and neurosurgery.Clin Neurol Neurosurg.2013 Feb;115(2):179-86. doi: 10.1016/j.clineuro.2012.05.013. Epub 2012 Jun 5.
• INTRODUCTION: Patients with myasthenia gravis, especially those in crises, are not infrequently observed to demonstrate wide fluctuation in heart rate and blood pressure.OBJECTIVE: This study was conducted to assess autonomic function in patients with myasthenia gravis.METHODS: Patients with myasthe
• PMID 22676958

Japanese Journal

• 抗MuSK抗体陽性全身型重症筋無力症の抗コリンエステラーゼ薬の効果

• 小西 哲郎,高坂 雅之,山川 健太郎 [他],松井 大,太田 潔江
• 臨床神経学 49(10), 660-663, 2009-10-01
• NAID 10026290576

• 閉口障害を契機に診断された重症筋無力症の2例

• 齋藤 高,浅田 洸一,臼井 弘幸 [他],豊田 長隆,栃原 しほみ,石橋 克禮
• 日本口腔外科学会雑誌 54(5), 339-343, 2008-05-20
• … Finally, they were given a diagnosis of MG by a neurologist on the basis of the Tensilon test.<BR>Oral surgeons have to consider MG in patients who have masticatory dysfunction with ocular symptoms. …
• NAID 10027088726

• 胸腺摘出術を行った全外眼筋麻痺を呈した眼筋型重症筋無力症の一例

• 溝渕 宗秀,河合 一重,敷島 敬悟,本田 英比古,長谷川 節
• 神経眼科 = Neuro-ophthalmology Japan 13(2), 201-205, 1996-06-25
• NAID 10016339214

Related Links

• Tensilon Test - definition of Tensilon Test in the Medical ...

Tensilon Test Definition Tensilon is the trade name for edrophonium chloride. The Tensilon test is an injection of edrophonium chloride used to diagnosis myasthenia gravis (MG). Purpose Tensilon blocks the action of an enzyme ...

• Tensilon test: MedlinePlus Medical Encyclopedia

How the Test is Performed A medicine called Tensilon (also called edrophonium) or a dummy medicine (inactive placebo) is given during this test. The health care provider gives the medicine through one of your veins ...

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リンク元	「テンシロンテスト」
関連記事	「testing」「test」「Tensilon」

「テンシロンテスト」

　　[★]

英

tensilon test

同

エドロホニウム試験 edrophonium test、アンチレックス試験 antilex test

関

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テンシロン試験 : 約 940 件
テンシロンテスト : 約 1,620 件
エドロホニウム試験 : 16 件
エドロホニウムテスト : 13 件
アンチレックス試験 : 4 件
アンチレックステスト : 7 件

臨床での利用

• 重症筋無力症を診断するための検査
• 重症筋無力症であれば、エドロフォニウムの静注により筋力が増す (SPC.158)

「testing」

　　[★]

• n.

• 試験

関

assessment、data quality、exam、examination、examine、experimental design、matched group、measurement、research design、scoring method、test、trial

　 　

「test」

　　[★] テスト 　 　 　 　 　 　 　 　 　 　

「Tensilon」

　　[★] エドロホニウム。テンシロン