タンデム・ア型カリウムチャネル

WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
(mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function
one behind the other; "ride tandem on a bicycle built for two"; "riding horses down the path in tandem" (同)in tandem
an arrangement of two or more objects or persons one behind another
any tiny hole admitting passage of a liquid (fluid or gas)
any small opening in the skin or outer surface of an animal
a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
(国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)
前後一留に; / 縦並びの,前後に座席のある / 縦につないだ2頭の馬;縦列2頭立ての馬車 / 二人乗り自転車
《pore over+名》(…を)熟読する,注意深く考える・没頭する, 熟考［熟視，熟読］する
気孔,毛穴
ポタシウム,カリウム(金属元素;化学記号はK)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/24 10:17:30」(JST)

wiki en

The two-pore-domain potassium channel (not to be confused with the small family of two-pore channels) a family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.^[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins .^{[citation needed]} Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:^[1]

Gene	Channel^[2]	Family	Aliases
KCNK1	K_2p1.1	TWIK^[3]^[4]	TWIK-1
KCNK2	K_2p2.1	TREK^[3]^[4]	TREK-1
KCNK3	K_2p3.1	TASK^[3]^[4]	TASK-1
KCNK4	K_2p4.1	TREK^[3]^[4]	TRAAK^[5]
KCNK5	K_2p5.1	TASK^[3]^[4]	TASK-2^[6]
KCNK6	K_2p6.1	TWIK^[3]^[4]	TWIK-2
KCNK7	K_2p7.1	TWIK^[3]^[4]
KCNK9	K_2p9.1	TASK^[3]^[4]	TASK-3
KCNK10	K_2p10.1	TREK^[3]^[4]	TREK-2
KCNK12	K_2p12.1	THIK	THIK-2
KCNK13	K_2p13.1	THIK	THIK-1
KCNK15	K_2p15.1	TASK^[3]^[4]	TASK-5
KCNK16	K_2p16.1	TALK^[3]^[4]	TALK-1
KCNK17	K_2p17.1	TALK^[3]^[4]	TALK-2, TASK-4
KCNK18	K_2p18.1		TRIK, TRESK^[3]^[4]^[7]^[8]

References

^ ^a ^b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
^ Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, and others (2003). "International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels". Pharmacological Reviews 55 (4): 583–6. doi:10.1124/pr.55.4.9. PMID 14657415.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m Enyedi P, Czirják G (2010). "Molecular background of leak K⁺ currents: two-pore domain potassium channels". Physiological Reviews 90 (2): 559–605. doi:10.1152/physrev.00029.2009. PMID 20393194.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m Lotshaw DP (2007). "Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels". Cell Biochemistry and Biophysics 47 (2): 209–56. doi:10.1007/s12013-007-0007-8. PMID 17652773.
^ Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (1998). "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids". The EMBO Journal 17 (12): 3297–308. doi:10.1093/emboj/17.12.3297. PMC 1170668. PMID 9628867.
^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nature Reviews Neuroscience 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
^ Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K (2003). "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord". The Journal of Biological Chemistry 278 (30): 27406–12. doi:10.1074/jbc.M206810200. PMID 12754259.
^ Czirják G, Tóth ZE, Enyedi P (2004). "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin". The Journal of Biological Chemistry 279 (18): 18550–8. doi:10.1074/jbc.M312229200. PMID 14981085.

External links

Tandem Pore Domain Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
"Two-P Potassium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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English Journal

Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels.

Bobak N, Bittner S, Andronic J, Hartmann S, Muhlpfordt F, Schneider-Hohendorf T, Wolf K, Schmelter C, Gobel K, Meuth P, Zimmermann H, Doring F, Wischmeyer E, Budde T, Wiendl H, Meuth SG, Sukhorukov VL.SourceUniversity of Muenster, Department of Neurology - Inflammatory Disorders of the Nervous System and Neurooncology, Domagkstr, 13, 48149 Muenster, Germany.
Biochimica et biophysica acta.Biochim Biophys Acta.2011 Aug;1808(8):2036-44. Epub 2011 May 5.
A variety of ion channels are supposed to orchestrate the homoeostatic volume regulation in T lymphocytes. However, the relative contribution of different potassium channels to the osmotic volume regulation and in particular to the regulatory volume decrease (RVD) in T cells is far from clear. This
PMID 21575593

Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons.

La JH, Gebhart GF.SourceCenter for Pain Research, Department of Anesthesiology, University of Pittsburgh, Pennsylvania, USA. laj@upmc.edu
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2011 Jul;301(1):G165-74. Epub 2011 Apr 21.
TREK-1, TREK-2 and TRAAK are mechanosensitive two-pore domain K(+) (K(2P)) channels thought to be involved in the attenuation of mechanotransduction. Because colon inflammation is associated with colon mechanohypersensitivity, we hypothesized that the role of these channels in colon sensory (dorsal
PMID 21512155