sunscreening agent

• 日焼け止め

関

sunscreen

WordNet

1. a cream spread on the skin; contains a chemical (as PABA) to filter out ultraviolet light and so protect from sunburn (同)sunblock, sun blocker
2. a substance that exerts some force or effect
3. a businessman who buys or sells for another in exchange for a commission (同)factor, broker
4. any agent or representative of a federal agency or bureau (同)federal agent
5. a representative who acts on behalf of other persons or organizations
6. an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
7. how long something has existed; "it was replaced because of its age"
8. a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
9. begin to seem older; get older; "The death of his wife caused him to age fast"
10. make older; "The death of his child aged him tremendously"

PrepTutorEJDIC

1. 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
2. 〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/03 16:41:39」(JST)

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For suntan lotion that intensifies sun exposure, see Indoor tanning lotion. For the electronic music group, see Sunblock (band). For the song, see Wear Sunscreen.

Sunscreen
Sunscreen on back under normal and UV light
Synonyms	Sun screen, sunblock, suntan lotion, sunburn cream, sun cream, block out

Sunscreen, also known as sunblock and suntan lotion, is a lotion, spray, gel or other topical product that absorbs or reflects some of the sun's ultraviolet (UV) radiation and thus helps protect against sunburn, especially for fair-skinned individuals. Diligent use of sunscreen can also slow or temporarily prevent the development of wrinkles and sagging skin.

Depending on the mode of action, sunscreens can be classified into physical sunscreens (i.e., those that reflect the sunlight) or chemical sunscreens (i.e., those that absorb the UV light).

Medical organizations such as the American Cancer Society recommend the use of sunscreen because it aids in the prevention of squamous cell carcinomas. Many sunscreens do not block UVA radiation, which does not primarily cause sunburn but can increase the rate of melanoma and photodermatitis. The use of broad-spectrum (UVA/UVB) sunscreens can address this concern.

Sunscreens are commonly rated and labeled with a sun protection factor (SPF) that measures the fraction of sunburn-producing UV rays that reach the skin. For example, "SPF 15" means that 1/15th of the burning radiation reaches the skin through the recommended thickness of sunscreen. Other rating systems indicate the degree of protection from non-burning UVA radiation.

Health effects

See also: Health effects of sunlight exposure

Benefits

Sunscreen use can help prevent melanoma and squamous cell carcinoma, two types of skin cancer. There is little evidence that it is effective in preventing basal cell carcinoma.

A 2013 study concluded that the diligent, everyday application of sunscreen can slow or temporarily prevent the development of wrinkles and sagging skin. The study involved 900 white people in Australia and required some of them to apply a broad-spectrum sunscreen every day for four and a half years. It found that people who did so had noticeably more resilient and smoother skin than those assigned to continue their usual practices.

Minimizing UV damage is especially important for children and fair-skinned individuals and those who have sun sensitivity for medical reasons.

Potential risks

In 2009, the Therapeutic Goods Administration of Australia updated a review of sunscreen safety studies and concluded: "The potential for titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles in sunscreens to cause adverse effects depend primarily upon the ability of the nanoparticles to reach viable skin cells. To date, the current weight of evidence suggests that TiO2 and ZnO nanoparticles do not reach viable skin cells." Sunscreen ingredients typically undergo extensive review by government regulators in multiple countries, and ingredients that present significant safety concerns (such as PABA) tend to be withdrawn from the consumer market.

Concerns have also been raised about potential vitamin D deficiency arising from prolonged use of sunscreen. Typical use of sunscreen does not usually result in vitamin D deficiency; however, extensive usage may. Sunscreen prevents ultraviolet light from reaching the skin, and even moderate protection can substantially reduce vitamin D synthesis. However, adequate amounts of vitamin D can be produced with moderate sun exposure to the face, arms and legs, averaging 5–30 minutes twice per week without sunscreen. (The darker the complexion, or the weaker the sunlight, the more minutes of exposure are needed, approximating 25% of the time for minimal sunburn. Vitamin D overdose is impossible from UV exposure; the skin reaches an equilibrium where the vitamin degrades as fast as it is created.)

Measurements of protection

Sunscreen helps prevent sunburn, such as this, which has blistered.

Sun protection factor and labeling

Two photographs showing the effect of applying sunscreens in visible light and in UVA. The photograph on the right was taken using ultraviolet photography shortly after application of sunscreen to half of the face.

The sun protection factor (SPF rating, introduced in 1974) is a measure of the fraction of sunburn-producing UV rays that reach the skin. For example, "SPF 15" means that 1/15th of the burning radiation will reach the skin, assuming sunscreen is applied evenly at a thick dosage of 2 milligrams per square centimeter (mg/cm²). A user can determine the effectiveness of a sunscreen "by multiplying the SPF factor by the length of time it takes for him or her to suffer a burn without sunscreen." Thus, if a person develops a sunburn in 10 minutes when not wearing a sunscreen, the same person in the same intensity of sunlight will avoid sunburn for 150 minutes if wearing a sunscreen with an SPF of 15. It is important to note that sunscreens with higher SPF do not last or remain effective on the skin any longer than lower SPF and must be continually reapplied as directed, usually every two hours.

The SPF is an imperfect measure of skin damage because invisible damage and skin aging are also caused by ultraviolet type A (UVA, wavelengths 315–400 or 320–400 nm), which does not primarily cause reddening or pain. Conventional sunscreen blocks very little UVA radiation relative to the nominal SPF; broad-spectrum sunscreens are designed to protect against both UVB and UVA. According to a 2004 study, UVA also causes DNA damage to cells deep within the skin, increasing the risk of malignant melanomas. Even some products labeled "broad-spectrum UVA/UVB protection" have not always provided good protection against UVA rays. Titanium dioxide probably gives good protection, but does not completely cover the UVA spectrum, as early 2000s research suggests that zinc oxide is superior to titanium dioxide at wavelengths 340–380 nm.

Owing to consumer confusion over the real degree and duration of protection offered, labeling restrictions are enforced in several countries. In the EU, sunscreen labels can only go up to SPF 50+ (initially listed as 30 but soon revised to 50). Australia's Therapeutic Goods Administration increased the upper limit to 50+ in 2012. In its 2007 and 2011 draft rules, the US Food and Drug Administration (FDA) proposed a maximum SPF label of 50, to limit unrealistic claims. (As of February 2017, the FDA has not adopted the SPF 50 limit.) Others have proposed restricting the active ingredients to an SPF of no more than 50, due to lack of evidence that higher dosages provide more meaningful protection.

UV sunlight spectrum (on a summer day in the Netherlands), along with the CIE Erythemal action spectrum. The effective spectrum is the product of the former two.

The SPF can be measured by applying sunscreen to the skin of a volunteer and measuring how long it takes before sunburn occurs when exposed to an artificial sunlight source. In the US, such an in vivo test is required by the FDA. It can also be measured in vitro with the help of a specially designed spectrometer. In this case, the actual transmittance of the sunscreen is measured, along with the degradation of the product due to being exposed to sunlight. In this case, the transmittance of the sunscreen must be measured over all wavelengths in sunlight's UVB–UVA range (290–400 nm), along with a table of how effective various wavelengths are in causing sunburn (the erythemal action spectrum) and the standard intensity spectrum of sunlight (see the figure). Such in vitro measurements agree very well with in vivo measurements.

Numerous methods have been devised for evaluation of UVA and UVB protection. The most-reliable spectrophotochemical methods eliminate the subjective nature of grading erythema.

The ultraviolet protection factor (UPF) is a similar scale developed for rating fabrics for sun protective clothing. According to recent testing by Consumer Reports, UPF ~30 is typical for protective fabrics, while UPF ~6 is typical for standard summer fabrics.

Mathematically, the SPF (or the UPF) is calculated from measured data as

$\mathrm {SPF} ={\frac {\int A(\lambda )E(\lambda )d\lambda }{\int A(\lambda )E(\lambda )/\mathrm {MPF} (\lambda )\,d\lambda }},$

where $E(\lambda )$ is the solar irradiance spectrum, $A(\lambda )$ the erythemal action spectrum, and $\mathrm {MPF} (\lambda )$ the monochromatic protection factor, all functions of the wavelength $\lambda$. The MPF is roughly the inverse of the transmittance at a given wavelength.

The above means that the SPF is not simply the inverse of the transmittance in the UVB region. If that were true, then applying two layers of SPF 5 sunscreen would always be equivalent to SPF 25 (5 times 5). The actual combined SPF may be lower than the square of the single-layer SPF.

UVA protection

Persistent pigment darkening

The persistent pigment darkening (PPD) method is a method of measuring UVA protection, similar to the SPF method of measuring sunburn protection. Originally developed in Japan, it is the preferred method used by manufacturers such as L'Oréal.

Instead of measuring erythema or reddening of the skin, the PPD method uses UVA radiation to cause a persistent darkening or tanning of the skin. Theoretically, a sunscreen with a PPD rating of 10 should allow a person 10 times as much UVA exposure as would be without protection. The PPD method is an in vivo test like SPF. In addition, Colipa has introduced a method that, it is claimed, can measure this in vitro and provide parity with the PPD method.

SPF equivalence

The UVA seal used in the EU

A tube of SPF 15 sun lotion

As part of revised guidelines for sunscreens in the EU, there is a requirement to provide the consumer with a minimum level of UVA protection in relation to the SPF. This should be a "UVA PF" of at least 1/3 of the SPF to carry the UVA seal.

A set of final US FDA rules effective from summer 2012 defines the phrase "broad spectrum" as providing UVA protection proportional to the UVB protection, using a standardized testing method.

Star rating system

In the UK and Ireland, the Boots star rating system is a proprietary in vitro method used to describe the ratio of UVA to UVB protection offered by sunscreen creams and sprays. Based on original work by Brian Diffey at Newcastle University, the Boots Company in Nottingham, UK, developed a method that has been widely adopted by companies marketing these products in the UK.

One-star products provide the lowest ratio of UVA protection, five-star products the highest. The method was recently revised in light of the Colipa UVA PF test and the revised EU recommendations regarding UVA PF. The method still uses a spectrophotometer to measure absorption of UVA versus UVB; the difference stems from a requirement to pre-irradiate samples (where this was not previously required) to give a better indication of UVA protection and photostability when the product is used. With the current methodology, the lowest rating is three stars, the highest being five stars.

In August 2007, the FDA put out for consultation the proposal that a version of this protocol be used to inform users of American product of the protection that it gives against UVA; but this was not adopted, for fear it would be too confusing.

PA system

Asian brands, particularly Japanese ones, tend to use The Protection Grade of UVA (PA) system to measure the UVA protection that a sunscreen provides. The PA system is based on the PPD reaction and is now widely adopted on the labels of sunscreens. According to the Japan Cosmetic Industry Association, PA+ corresponds to a UVA protection factor between two and four, PA++ between four and eight, and PA+++ more than eight. This system was revised in 2013 to include PA++++ which corresponds to a PPD rating of sixteen or above.

Sunblock

Sunblock typically refers to opaque sunscreen that is effective at blocking both UVA and UVB rays and uses a heavy carrier oil to resist being washed off. Titanium dioxide and zinc oxide are two minerals that are used in sunblock.

The use of the word "sunblock" in the marketing of sunscreens is controversial. Since 2013, the FDA has banned such use because it can lead consumers to overestimate the effectiveness of products so labeled. Nonetheless, many consumers use the words sunblock and sunscreen synonymously.

For total protection against damage from the sun, the skin needs to be protected from UVA, UVB, and also IRA (infrared-A light). Roughly 35% of solar energy is IRA.

Active ingredients

In addition to moisturizers and other inactive ingredients, sunscreens contain one or more of the following active ingredients, which are either chemical or mineral in nature:

• Organic chemical compounds that absorb ultraviolet light.
• Inorganic particulates that reflect, scatter, and absorb UV light (such as titanium dioxide, zinc oxide, or a combination of both).
• Organic particulates that mostly absorb UV light like organic chemical compounds, but contain multiple chromophores that reflect and scatter a fraction of light like inorganic particulates. An example is Tinosorb M. The mode of action is about 90% by absorption and 10% by scattering.

The principal active ingredients in sunscreens are usually aromatic molecules conjugated with carbonyl groups. This general structure allows the molecule to absorb high-energy ultraviolet rays and release the energy as lower-energy rays, thereby preventing the skin-damaging ultraviolet rays from reaching the skin. So, upon exposure to UV light, most of the ingredients (with the notable exception of avobenzone) do not undergo significant chemical change, allowing these ingredients to retain the UV-absorbing potency without significant photodegradation. A chemical stabilizer is included in some sunscreens containing avobenzone to slow its breakdown; examples include formulations containing Helioplex and AvoTriplex. The stability of avobenzone can also be improved by bemotrizinol, octocrylene and various other photostabilisers. Most organic compounds in sunscreens slowly degrade and become less effective over the course of several years if stored properly, resulting in the expiration dates calculated for the product.

Sunscreening agents are used in some hair care products such as shampoos, conditioners and styling agents to protect against protein degradation and color loss. Currently, benzophenone-4 and ethylhexyl methoxycinnamate are the two sunscreens most commonly used in hair products. The common sunscreens used on skin are rarely used for hair products due to their texture and weight effects.

The following are the FDA allowable active ingredients in sunscreens:

UV-filter	Other names	Maximum concentration	Permitted in these countries	Results of safety testing	UVA	UVB
p-Aminobenzoic acid	PABA	15% (EU: banned from sale to consumers from 8 October 2009)	USA, AUS	Protects against skin tumors in mice. Shown to increase DNA defects, however, and is now less commonly used.		X
Padimate O	OD-PABA, octyldimethyl-PABA, σ-PABA	8% (EU, USA, AUS) 10% (JP) (Not currently supported in EU and may be delisted)	EU, USA, AUS, JP			X
Phenylbenzimidazole sulfonic acid	Ensulizole, Eusolex 232, PBSA, Parsol HS	4% (US, AUS) 8% (EU) 3% (JP)	EU, USA, AUS, JP	Genotoxic in bacteria		X
Cinoxate	2-Ethoxyethyl p-methoxycinnamate	3% (US) 6% (AUS)	USA, AUS		X	X
Dioxybenzone	Benzophenone-8	3%	USA, AUS		X	X
Oxybenzone	Benzophenone-3, Eusolex 4360, Escalol 567	6% (US) 10% (AUS, EU) 5% (JP)	EU, USA, AUS, JP		X	X
Homosalate	Homomethyl salicylate, HMS	10% (EU, JP) 15% (US, AUS)	EU, USA, AUS, JP			X
Menthyl anthranilate	Meradimate	5%	USA, AUS		X
Octocrylene	Eusolex OCR, 2-Cyano-3,3-diphenyl acrylic acid, 2-ethylhexylester	10%	EU, USA, AUS, JP	Increases ROS	X	X
Octyl methoxycinnamate	Octinoxate, EMC, OMC, Ethylhexyl methoxycinnamate, Escalol 557, 2-Ethylhexyl-paramethoxycinnamate, Parsol MCX	7.5% (US) 10% (EU, AUS) 20% (JP)	EU, USA, AUS, JP			X
Octyl salicylate	Octisalate, 2-Ethylhexyl salicylate, Escalol 587,	5% (EU, USA, AUS) 10% (JP)	EU, USA, AUS, JP			X
Sulisobenzone	2-Hydroxy-4-Methoxybenzophenone-5-sulfonic acid, 3-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid, Benzophenone-4, Escalol 577	5% (EU) 10% (US, AUS, JP)	EU, USA, AUS, JP		X	X
Trolamine salicylate	Triethanolamine salicylate	12%	USA, AUS			X
Avobenzone	1-(4-methoxyphenyl)-3-(4-tert-butyl phenyl)propane-1,3-dione, Butyl methoxy dibenzoylmethane, BMDBM, Parsol 1789, Eusolex 9020	3% (US) 5% (EU, AUS) 10% (JP)	EU, USA, AUS, JP	Not available	X
Ecamsule	Mexoryl SX, Terephthalylidene Dicamphor Sulfonic Acid	10%	EU, AUS (US: approved in certain formulations up to 3% via New Drug Application (NDA) Route)	Protects against skin tumors in mice	X
Titanium dioxide	CI77891	25% (US) No limit (JP)	EU, USA, AUS, JP		X	X
Zinc oxide		25% (US) No limit (AUS, JP)	EU, USA, AUS, JP	Protects against skin tumors in mice	X	X

Zinc oxide was approved as a UV filter by the EU in 2016.

Other ingredients approved within the EU and other parts of the world, that have not been included in the current FDA Monograph:

UV-filter	Other names	Maximum concentration	Permitted in
4-Methylbenzylidene camphor	Enzacamene, Parsol 5000, Eusolex 6300, MBC	4%*	EU, AUS
Tinosorb M	Bisoctrizole, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, MBBT	10%*	EU, AUS, JP
Tinosorb S	Bis-ethylhexyloxyphenol methoxyphenol triazine, Bemotrizinol, BEMT, anisotriazine	10% (EU, AUS) 3% (JP)*	EU, AUS, JP
Tinosorb A2B	Tris-Biphenyl Triazine	10%	EU
Neo Heliopan AP	Bisdisulizole Disodium, Disodium phenyl dibenzimidazole tetrasulfonate, bisimidazylate, DPDT	10%	EU, AUS
Mexoryl XL	Drometrizole Trisiloxane	15%	EU, AUS
Benzophenone-9	Uvinul DS 49, CAS 3121-60-6, Sodium Dihydroxy Dimethoxy Disulfobenzophenone	10%	JP
Uvinul T 150	Octyl triazone, ethylhexyl triazone, EHT	5% (EU, AUS) 3% (JP)*	EU, AUS
Uvinul A Plus	Diethylamino Hydroxybenzoyl Hexyl Benzoate	10% (EU,JP)	EU, JP
Uvasorb HEB	Iscotrizinol, Diethylhexyl butamido triazone, DBT	10% (EU) 5% (JP)*	EU, JP
Parsol SLX	Dimethico-diethylbenzalmalonate, Polysilicone-15	10%	EU, AUS, JP
Amiloxate	Isopentyl-4-methoxycinnamate, Isoamyl p-Methoxycinnamate, IMC, Neo Heliopan E1000	10%*	EU, AUS

^* Time and Extent Application (TEA), Proposed Rule on FDA approval originally expected 2009, now expected 2015.

Many of the ingredients awaiting approval by the FDA were relatively new, and developed to absorb UVA. The 2014 Sunscreen Innovation Act was passed to accelerate the FDA approval process.

Application

The dose used in FDA sunscreen testing is 2 mg/cm² of exposed skin. If one assumes an "average" adult build of height 5 ft 4 in (163 cm) and weight 150 lb (68 kg) with a 32-inch (82-cm) waist, that adult wearing a bathing suit covering the groin area should apply approximately 30 g (or 30 ml, approximately 1 oz) evenly to the uncovered body area. This can be more easily thought of as a "golf ball" size amount of product per body, or at least six teaspoonfuls. Larger or smaller individuals should scale these quantities accordingly. Considering only the face, this translates to about 1/4 to 1/3 of a teaspoon for the average adult face.

Some studies have shown that people commonly apply only 1/4 to 1/2 of the amount recommended for achieving the rated sun protection factor (SPF), and in consequence the effective SPF should be downgraded to a square root or 4th root of the advertised value. A later study found a significant exponential relation between SPF and the amount of sunscreen applied, and the results are closer to linearity than expected by theory.

Regulation

United States

Sunscreen labeling standards have been evolving in the United States since the FDA first adopted the SPF calculation in 1978. The FDA issued a comprehensive set of rules in June 2011, taking effect in 2012–2013, designed to help consumers identify and select suitable sunscreen products offering protection from sunburn, early skin aging, and skin cancer:

• To be classified as "broad spectrum", sunscreen products must provide protection against both UVA and UVB, with specific tests required for both.
• Claims of products being "waterproof" or "sweatproof" are prohibited, while "sunblock" and "instant protection" and "protection for more than 2 hours" are all prohibited without specific FDA approval.
• "Water resistance" claims on the front label must indicate how long the sunscreen remains effective and specify whether this applies to swimming or sweating, based on standard testing.
• Sunscreens must include standardized "Drug Facts" information on the container. However, there is no regulation that deems it necessary to mention whether the contents contain nanoparticles of mineral ingredients. (The EU has stricter regulation against the use of nanoparticles, and in 2009 introduced labeling requirements for nanoparticle ingredients in certain sunscreens and cosmetics.)

Environmental effects

Certain sunscreens in water under ultraviolet light can increase the production of hydrogen peroxide, which damages phytoplankton. Oxybenzone damages coral. Nanoparticles of titanium dioxide, an ingredient in some sunscreens, can accumulate in coastal waters and be ingested by marine animals.

History

Early civilizations used a variety of plant products to help protect the skin from sun damage. For example, ancient Greeks used olive oil for this purpose, and ancient Egyptians used extracts of rice, jasmine, and lupine plants whose products are still used in skin care today. Zinc oxide paste has also been popular for skin protection for thousands of years.

Early synthetic sunscreens were first used in 1928. The first major commercial product was brought to market in 1936, introduced by the founder of L'Oreal, French chemist Eugène Schueller.

Among widely used modern sunscreens, one of the earliest was produced in 1944 for the US military by Benjamin Green, an airman and later a pharmacist, as the hazards of sun overexposure became apparent to soldiers in the Pacific tropics at the height of World War II. The product, named Red Vet Pet (for red veterinary petrolatum), had limited effectiveness, working as a physical blocker of ultraviolet radiation. It was a disagreeable red, sticky substance similar to petroleum jelly. Sales boomed when Coppertone improved and commercialized the substance under the Coppertone girl and Bain de Soleil branding in the early 1950s.

In 1946, Swiss chemist Franz Greiter introduced what may have been the first effective modern sunscreen. The product, called Gletscher Crème (Glacier Cream), subsequently became the basis for the company Piz Buin, which is still today a marketer of sunscreen products, named in honor of the mountain where Greiter allegedly received the sunburn that inspired his concoction. In 1974, Greiter adapted earlier calculations from Friedrich Ellinger and Rudolf Schulze and introduced the "sun protection factor" (SPF), which has become a worldwide standard for measuring the effectiveness of sunscreen. It has been estimated that Gletscher Crème had an SPF of 2.

Water-resistant sunscreens were introduced in 1977, and recent development efforts have focused on overcoming later concerns by making sunscreen protection both longer-lasting and broader-spectrum, as well as more appealing to use.

Research

New products are in development such as sunscreens based on bioadhesive nanoparticles. These function by encapsulating commercially used UV filters, while being not only adherent to the skin but also non-penetrant. This strategy inhibits primary UV-induced damage as well as secondary free radicals.

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English Journal

• Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts.

• Britto SM1, Shanthakumari D2, Agilan B3, Radhiga T3, Kanimozhi G3, Prasad NR4.
• Mutation research.Mutat Res.2017 Sep;821:28-35. doi: 10.1016/j.mrgentox.2017.06.002. Epub 2017 Jun 27.
• PMID 28735741

• Phototoxic assessment of a sunscreen formulation and its excipients: An in vivo and in vitro study.

• Hossy BH1, da Costa Leitão AA2, Dos Santos EP3, Matsuda M4, Rezende LB5, Rurr JSC2, Pinto AV6, Ramos-E-Silva M1, de Pádula M7, de Oliveira Miguel NC8.
• Journal of photochemistry and photobiology. B, Biology.J Photochem Photobiol B.2017 Aug;173:545-550. doi: 10.1016/j.jphotobiol.2017.06.043. Epub 2017 Jun 29.
• PMID 28692926

• Photolysis and cellular toxicities of the organic ultraviolet filter chemical octyl methoxycinnamate and its photoproducts.

• Stein HV1, Berg CJ, Maung JN, O'Connor LE, Pagano AE, MacManus-Spencer LA, Paulick MG.
• Environmental science. Processes & impacts.Environ Sci Process Impacts.2017 Jun 21;19(6):851-860. doi: 10.1039/c7em00059f.
• PMID 28534578

Japanese Journal

• ナノテクノロジーを活用した高耐水性サンスクリーン剤の開発 (シンポジウム:ナノテクノロジーの化粧品,医薬品への応用:香粧品分野への応用)

• 石井 宏明
• 日本香粧品学会誌 29(3), 215-220, 2005-09-00
• NAID 40006991571

• ナノテクを利用したラスティングサンスクリーン剤の開発 (特集/ナノテクノロジーと香粧品科学)

• 黒田 章裕,朝倉 浩一
• フレグランスジャーナル 31(8), 49-54, 2003-08-00
• NAID 80016097317

• 滑水現象を利用した耐水性サンスクリーン剤の開発 (特集 紫外線の防御とケア)

• 黒田 章裕
• フレグランスジャーナル 30(7), 28-32, 2002-07-00
• NAID 40005512116

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★リンクテーブル★

リンク元	「日焼け止め」
関連記事	「agent」「age」

「日焼け止め」

　　[★]

英

sunscreen、sunscreening agent

「agent」

　　[★]

• n.

• 代行者、代理人。代理業者
• 政府職員、官吏
• ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、～剤。病原体

関

agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle

　 　 　 　 　 　

「age」

　　[★]

• n.

• 年齢、歳

• v.

• 加齢する、熟成する

関

aged、ageing、aging、year old