特殊顆粒
WordNet
- stated explicitly or in detail; "needed a specific amount"
- a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"
- (sometimes followed by `to'
- being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"
- relating to or distinguishing or constituting a taxonomic species; "specific characters"
- a tiny grain
PrepTutorEJDIC
- 《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)
- 小粒,微粒
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/12 18:35:06」(JST)
[Wiki en表示]
Specific granules are secretory vesicles found exclusively in cells of the immune system called granulocytes. They are also known as secondary granules.
It is sometimes described as applying specifically to neutrophils,[1] and sometimes the term is applied to other types of cells.[2]
These granules store a mixture of cytotoxic molecules, including many enzymes and antimicrobial peptides, that are released by a process called degranulation following activation of the granulocyte by an immune stimulus.
Specific granules are also known as "secondary granules".[3]
Contents
- 1 Contents
- 2 Clinical significance
- 3 References
- 4 External links
Contents
Examples of cytotoxic molecule stored by specific granules in different granulocytes include:
- Neutrophil: alkaline phosphatase, lactoferrin, lysozyme, NADPH oxidase
- Eosinophil: cathepsin, major basic protein
- Basophil: heparin, histamine (not directly cytotoxic)
Clinical significance
A specific granule deficiency can be associated with CEBPE.[4]
References
- ^ "Definition: specific granule from Online Medical Dictionary".
- ^ Okuda M, Takenaka T, Kawabori S, Ogami Y (July 1981). "Ultrastructural study of the specific granule of the human eosinophil". J. Submicrosc. Cytol. 13 (3): 465–71. PMID 7334549.
- ^ John P. Greer; Maxwell Myer Wintrobe (1 December 2008). Wintrobe's clinical hematology. Lippincott Williams & Wilkins. pp. 173–. ISBN 978-0-7817-6507-7. Retrieved 10 November 2010.
- ^ Online 'Mendelian Inheritance in Man' (OMIM) SPECIFIC GRANULE DEFICIENCY; SGD -245480
External links
- Neutrophil granules at sav.sk
Antimicrobial peptides: Granulocyte granule contents
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Azurophilic granules (1°) |
- Myeloperoxidase
- Defensins
- neutral serine proteases (Proteinase 3)
- Lysozyme
- Bactericidal/permeability-increasing protein
- Collagenase
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Specific granules (2°) |
Neutrophil |
- Alkaline phosphatase
- Lactoferrin
- Lysozyme
- NADPH oxidase
- Collagenase
- Cathelicidin
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|
Eosinophil |
- Cathepsin
- Major basic protein
- Eosinophil cationic protein
- Eosinophil peroxidase
- Eosinophil-derived neurotoxin
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Basophil |
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- see also platelet alpha-granule, dense granule
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Index of cells from bone marrow
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Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
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|
Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
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Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
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|
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UpToDate Contents
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English Journal
- Quantification of heterotypic granule fusion in human neutrophils by imaging flow cytometry.
- Björnsdottir H1, Welin A2, Dahlgren C2, Karlsson A2, Bylund J1.
- Data in brief.Data Brief.2015 Dec 17;6:386-93. doi: 10.1016/j.dib.2015.12.003. eCollection 2016.
- Human neutrophils are filled with intracellular storage organelles, called granules and secretory vesicles, which differ in their content of soluble matrix proteins and membrane-bound molecules. To date, at least four distinct granule/vesicle subsets have been identified. These organelles may secret
- PMID 26862586
- Pattern of CXCR7 Gene Expression in Mouse Brain Under Normal and Inflammatory Conditions.
- Banisadr G1, Podojil JR2, Miller SD2, Miller RJ3.
- Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.J Neuroimmune Pharmacol.2016 Mar;11(1):26-35. doi: 10.1007/s11481-015-9616-y. Epub 2015 May 22.
- The chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 acting via its G-protein coupled receptor (GPCR) CXCR4 has been implicated in neurogenesis, neuromodulation, brain inflammation, HIV-1 encephalopathy and tumor growth. CXCR7 was identified as an alternate receptor for SDF-1/CXCL12. Character
- PMID 25997895
- Mechanisms of immune escape in central nervous system infection with neurotropic JC virus variant.
- Jelcic I1, Jelcic I1, Kempf C1, Largey F1, Planas R1, Schippling S1, Budka H2, Sospedra M1, Martin R1.
- Annals of neurology.Ann Neurol.2016 Feb 13. doi: 10.1002/ana.24574. [Epub ahead of print]
- OBJECTIVE: Symptomatic infections of the central nervous system (CNS) with JC polyomavirus (JCV) usually occur as a result of immunocompromise and manifest as progressive multifocal leukoencephalopathy (PML) or granule cell neuronopathy (GCN). After immune reconstitution, some of these cases may sho
- PMID 26874214
Japanese Journal
- 精神疾患の中間表現型としての未成熟歯状回(2012年度 第2回フォーラム基礎心理学のための基礎研究-網膜,遺伝子,インタフェース-)
- 昌子 浩孝,萩原 英雄,高雄 啓三,WALTON Noah M.,松本 光之,宮川 剛
- 基礎心理学研究 32(1), 101-119, 2013-09-30
- … In these mutant mice, almost all neurons in the dentate gyrus are at a pseudo-immature properties, whihc we referred to as "immature dentate gyrus (iDG)." To date, the iDG phenotype have been found in mustant strains including Schnurri-2 knockout, SNAP-25 mutant, and forebrain-specific calcineurin knockout mice which show similar behavioral phenotypes. …
- NAID 110009685451
- 海馬歯状回穎粒細胞の樹状突起上における空間情報・非空間情報の相互作用
- 早川 博章,上條 中庸,佐村 俊和,相原 威
- 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 112(390), 199-204, 2013-01-17
- 海馬歯状回穎粒細胞の樹状突起は、嗅内野II層から場所などの空間情報と匂いなどの非空間情報の2系統の異なった入力を受ける。そしてこれらの情報は、樹状突起の遠位部と中位部にわかれてそれぞれ独立に入力することが知られている。先行研究において、この空間情報を記憶する際に匂いを嗅がせると海馬依存的な再認課題の成績が有意に向上することが報告されていることから、非空間情報が空間情報の処理に影響を与えている可能性 …
- NAID 110009728146
- 海馬歯状回穎粒細胞の樹状突起上における空間情報・非空間情報の相互作用
- 早川 博章,上條 中庸,佐村 俊和,相原 威
- 電子情報通信学会技術研究報告. NLP, 非線形問題 112(389), 199-204, 2013-01-17
- 海馬歯状回穎粒細胞の樹状突起は、嗅内野II層から場所などの空間情報と匂いなどの非空間情報の2系統の異なった入力を受ける。そしてこれらの情報は、樹状突起の遠位部と中位部にわかれてそれぞれ独立に入力することが知られている。先行研究において、この空間情報を記憶する際に匂いを嗅がせると海馬依存的な再認課題の成績が有意に向上することが報告されていることから、非空間情報が空間情報の処理に影響を与えている可能性 …
- NAID 110009727603
Related Links
- Neutrophil-specific granule deficiency (SGD, previously called lactoferrin deficiency) is a rare congenital disorder. The cardinal clinical feature is increased susceptibility to pyogenic infections. Patients often present with large ...
- 17,91) Electron microscopic analysis of the neutrophilic inclusions shows them to lack a limiting membrane, be free of specific granules, and contain parallel ... Disclaimer All content on this website, including dictionary, thesaurus ...
Related Pictures
★リンクテーブル★
[★]
- 英
- specific granule
- 関
- 二次顆粒
[★]
- 英
- secondary granule
- 同
- 特殊顆粒 specific granule
- 関
- 骨髄球
[★]
- 関
- specific granule deficiency
[★]
- (~に関して)明確な、はっきりとした(exact precise)、具体的な(in, about)
- (比較)(限定)特定の(particular)、一定の(⇔general)
- (~に)特有の、独特の(to)
- (比較)(医学)(~に)渡航のある(for)。特殊な
- (生物)(生物)種の
- 医学)特異の
- (物理)比の。物質固有の。単位質量・長さ・面積・容積で
n.
- 関
- specifically、specificity
[★]
- 関
- granular