- 部位特異的な
WordNet
- serve in a specific professional capacity; "the priest sat for confession"; "she sat on the jury"
- be around, often idly or without specific purpose; "The object sat in the corner"; "We sat around chatting for another hour" (同)sit around
- be seated (同)sit_down
- be in session; "When does the court of law sit?"
- be located or situated somewhere; "The White House sits on Pennsylvania Avenue"
- stated explicitly or in detail; "needed a specific amount"
- a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"
- (sometimes followed by `to'
- being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"
- relating to or distinguishing or constituting a taxonomic species; "specific characters"
- the piece of land on which something is located (or is to be located); "a good site for the school" (同)land site
- physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides" (同)situation
PrepTutorEJDIC
- (…に)『座る』,座っている《+『at』(『on, in』)+『名』》・着席する《+『down』》・(…に)〈鳥などが〉『止まる』,休む《+『on』+『名』》・〈めんどりが〉卵を抱く,巣に就く / 《場所の副詞[句]を伴って》(ある場所に)『位置する』・ (画家・写真家のために)ポーズをとる・しっとしている,動かないでいる・(議員・委員などの)職に就いている《+『on』+『名』》・〈議会・法廷などが〉開会(開廷)される・(…に)負担となる,重荷となる《+『on』(『upon』)+『名』》・〈衣服などが〉(…に)合う,似合う《+『on』+『名』》・〈人〉‘を'座らせる,着席させる《+『down』+『名,』+『名』+『down』》・〈馬〉‘に'乗る・《英》〈試験〉‘を'受ける
- 《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)
- (町・建物などの)『場所』;敷地,用地 / 遺跡;(事件などの)現場 / 〈建物など〉‘を'位置させる(locate)
- =ti
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/16 01:19:53」(JST)
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- 1. 前立腺癌のスクリーニング screening for prostate cancer
- 2. 原発不明の低分化癌 poorly differentiated carcinoma of unknown primary site
- 3. 原発不明の低分化腫瘍 poorly differentiated neoplasms of unknown primary site
- 4. 原発不明の腺癌 adenocarcinoma of unknown primary site
- 5. 膣後壁欠損の外科的管理 surgical management of posterior vaginal defects
English Journal
- A portable and chromogenic enzyme-based sensor for detection of abrin poisoning.
- Cho H1, Jaworski J2.Author information 1Department of Chemical Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea; Institute of Nanoscience and Technology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea.2Department of Chemical Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea; Institute of Nanoscience and Technology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea. Electronic address: justynj@hanyang.ac.kr.AbstractA first of its kind portable, colorimetric detection system has been developed for the rapid diagnosis of abrin poisoning. Abrin, a natural biotoxin that is homologous to ricin yet more lethal, has high potential for becoming a weapon of bioterrorism given its ease of production. Using an immobilization strategy that implements non-natural amino acids for site-specific conjugation, we have created a reusable N-methyltryptophan oxidase based magnetic bead system that is capable of detecting L-abrine, a marker for abrin poisoning, at concentrations as low as 4μM in mock urine. Furthermore, we propose that this detection strategy may be readily adaptable for sensing other targets of interest. This unique diagnostic test for abrin poisoning has demonstrated key benefits of portability and simple visual readout. These significant advantages can thus provide the potential for more rapid assessment and corresponding poison management if dedicated toxicology laboratories are not an option.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:667-73. doi: 10.1016/j.bios.2013.11.058. Epub 2013 Nov 27.
- A first of its kind portable, colorimetric detection system has been developed for the rapid diagnosis of abrin poisoning. Abrin, a natural biotoxin that is homologous to ricin yet more lethal, has high potential for becoming a weapon of bioterrorism given its ease of production. Using an immobiliza
- PMID 24334282
- Chemiluminescence resonance energy transfer biosensing platform for site-specific determination of DNA methylation and assay of DNA methyltransferase activity using exonuclease III-assisted target recycling amplification.
- Chen C1, Li B2.Author information 1Key laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.2Key laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China. Electronic address: libaoxin@snnu.edu.cn.AbstractSite-specific determination of DNA methylation and assay of MTase activity can be used for determining specific cancer types, providing insights into the mechanism of gene repression, and developing novel drugs to treat methylation-related diseases. Herein, we develop a simple and highly sensitive chemiluminescence (CL) biosensing platform for site-specific determination of DNA methylation using Exonuclease III (Exo III)-assisted target recycling signal amplification. After bisulfite treatment of mixture of methylated DNA and unmethylated DNA, methylated DNA can hybridize with fluorescein (FAM)-labeled probe DNA to form double-stranded DNA (dsDNA), removing the FAM-labeled probe DNA from the surface of grapheme oxide, and the chemiluminescence resonance energy transfer (CRET) sensing signal can be observed and then amplified using Exo III-based recycling strategy. The biosensing platform exhibits excellent high sensitivity, and it can ever distinguish as low as 0.002% methylation level from the mixture, which is superior to most currently reported methods used for DNA methylation assay. In addition, the proposed method can also be used to sensitively assay MTase activity with determination limit of 0.007U/mL. This CL biosensing offers the advantages of being facile, sensitive, rapid and cost-effective. These features make the system promising for future use for early cancer diagnosis and discover of new anticancer drugs.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:48-54. doi: 10.1016/j.bios.2013.10.050. Epub 2013 Oct 31.
- Site-specific determination of DNA methylation and assay of MTase activity can be used for determining specific cancer types, providing insights into the mechanism of gene repression, and developing novel drugs to treat methylation-related diseases. Herein, we develop a simple and highly sensitive c
- PMID 24240168
- Label-free electrochemical biosensor using home-made 10-methyl-3-nitro-acridone as indicator for picomolar detection of nuclear factor kappa B.
- Chen JH, Zhang X, Cai S, Wu D, Lin J, Li C, Zhang J.Author information Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350004, China. Electronic address: cjh_huaxue@126.com.AbstractA new acridone derivative 10-methyl-3-nitro-acridone (MNA) with excellent electrochemical activity was synthesized in this paper. Using it as an electrochemical indicator, a signal-on and label-free electrochemical biosensor was developed for picomolar determination of nuclear factor kappa B (NF-κB) in serum. Initially, linear double-stranded DNA (dsDNA) probes, which contain a protein-binding site specific to NF-κB, were self-assembled on the surface of a glass carbon electrode (GCE). If the NF-κB was absent, the dsDNA probes were cut into ss-DNA fragments by the digestion of ExoIII, resulting in a low electrochemical signal of MNA due to the weak binding affinity of MNA to ss-DNA. On the contrary, in the presence of NF-κB, it could bind with the dsDNA probes at the specific site and hinder the digestion of ExoIII, resulting in a significant increase of electrochemical response due to the intercalation of MNA into the dsDNA probes. By employing the above strategy, this sensor could detect as low as 40 pM NF-κB with high specificity. To the best of our knowledge, the proposed sensor is the first attempt to use acridone derivative as an electrochemical indicator for NF-κB detection, which may represent a promising path toward clinical diagnosis and drug developments.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Mar 15;53:12-7. doi: 10.1016/j.bios.2013.09.038. Epub 2013 Sep 25.
- A new acridone derivative 10-methyl-3-nitro-acridone (MNA) with excellent electrochemical activity was synthesized in this paper. Using it as an electrochemical indicator, a signal-on and label-free electrochemical biosensor was developed for picomolar determination of nuclear factor kappa B (NF-κB
- PMID 24103574
Japanese Journal
- Neural, hormonal and experiential control of sex-typical expression of social behavior (Special issue : proceedings of parvo- and magnocellular symposium in Sendai : creating a new stream of neuroendocrinology)
- Interdisciplinary Information Sciences 21(3), 181-187, 2015-09
- NAID 110009966526
- 近接する2つの物体間の「力」と「電流」の関係(最近の研究から)
- 日本物理學會誌 70(8), 620-624, 2015-08-05
- NAID 110009976844
- Improved transgene integration into the Chinese hamster ovary cell genome using the Cre-loxP system(CELL AND TISSUE ENGINEERING)
- Journal of bioscience and bioengineering 120(1), 99-106, 2015-07
- NAID 110009973292
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Related Pictures
★リンクテーブル★
「site-directed」
- 部位特異的な
「部位特異的」
「type III site-specific deoxyribonuclease」
「type II site-specific deoxyribonuclease」
「type I site-specific deoxyribonuclease」
「site-specific mutagenesis」
「specific」
- adj.
- (～に関して)明確な、はっきりとした(exact precise)、具体的な(in, about)
- (比較)(限定)特定の(particular)、一定の(⇔general)
- (～に)特有の、独特の(to)
- (比較)(医学)(～に)渡航のある(for)。特殊な
- (生物)(生物)種の
- 医学)特異の
- (物理)比の。物質固有の。単位質量・長さ・面積・容積で
n.
「sit」
- vi.
- (過去-過去分詞sat)座る、位置する
「site」
- n.