WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 19th letter of the Roman alphabet (同)s
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

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1. インスリン様成長因子 Iの生理学 physiology of insulin like growth factor i
2. 移植免疫 transplantation immunobiology
3. T細胞受容体シグナル伝達 t cell receptor signaling
4. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
5. プロテインC欠乏症：臨床症状および診断 protein c deficiency clinical manifestations and diagnosis

MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K.

Guégan JP1, Ezan F, Gailhouste L, Langouët S, Baffet G.
Journal of cellular physiology.J Cell Physiol.2014 Jul;229(7):903-15. doi: 10.1002/jcp.24521.
The extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase pathway has been involved in the positive and negative regulation of cell proliferation. Upon mitogen stimulation, ERK1/ERK2 activation is necessary for G1- to S-phase progression whereas when hyperactived, thi
PMID 24501087

Adiponectin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the AMPK/mTOR pathway.

Zhan JK1, Wang YJ1, Wang Y1, Tang ZY1, Tan P1, Huang W1, Liu YS2.
Experimental cell research.Exp Cell Res.2014 May 1;323(2):352-8. doi: 10.1016/j.yexcr.2014.02.016. Epub 2014 Mar 4.
Vascular calcification is common in patients with peripheral artery diseases and coronary artery diseases. The osteoblastic differentiation of vascular smooth muscle cells (VSMCs) contributes significantly to vascular calcification. Adiponectin has been demonstrated to exert a protective effect in o
PMID 24607448

Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas.

Takahashi Y1, Kohashi K1, Yamada Y1, Endo M1, Setsu N1, Ishii T1, Yamamoto H1, Iwamoto Y2, Oda Y3.
Human pathology.Hum Pathol.2014 May;45(5):984-93. doi: 10.1016/j.humpath.2013.12.012. Epub 2014 Jan 8.
The Akt/mammalian target of rapamycin (mTOR) pathway plays important roles in modulating cellular function in response to extracellular signals such as growth factors and cytokines. The Akt/mTOR signaling pathway is activated in certain kinds of sarcomas. Myxofibrosarcoma is a soft tissue sarcoma, c
PMID 24746202

Ethionine-Induced ATP Depletion Represses mTOR Signaling in the Absence of Increases in AMP-Activated Protein Kinase Activity in the Rat Liver

YOSHIZAWA Fumiaki,MOCHIZUKI Shinji,DOI Masako,YAMAOKA Ippei,SUGAHARA Kunio
Bioscience, biotechnology, and biochemistry 73(9), 1984-1988, 2009-09-23
… of ethionine to female rats caused a rapid and severe decline in liver ATP and inhibited hepatic protein synthesis in association with hypophosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1), two key regulatory proteins involved in initiation of mRNA …
NAID 10027545444

Time Course of Leucine-induced 4E-BP1 and S6K1 Phosphorylation in the Liver and Skeletal Muscle of Rats

YOSHIZAWA Fumiaki,SEKIZAWA Haruhito,HIRAYAMA Sachiyo,HATAKEYAMA Atsushi,NAGASAWA Takashi,SUGAHARA Kunio
Journal of nutritional science and vitaminology 47(4), 311-315, 2001-08-01
… The phosphorylation of the eukaryotic initiation factor (eIF)4E-binding protein 1 (4E-BP 1) frees eIF4E and stimulates protein synthesis by accelerating translation initiation. …
NAID 10010806266