UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. うつ病における症状測定および治療のための尺度の使用（測定に基づくケア）using scales to monitor symptoms and treat depression measurement based care [show details]
… both the number of dose adjustments and the antidepressant doses were greater with measurement based care, but adverse effects were comparable for the two groups.… and Burden of Side Effects Rating scale has good internal consistency. Test-retest reliability over two to three weeks was significant…
2. 医師による自殺幇助と安楽死：患者の願いの理解と評価、それへの対応physician assisted dying understanding evaluating and responding to requests for medical aid in dying [show details]
… including recommended doses, ingestion strategies, and managing potential side effects,… where both are legal because of its reliability, efficiency, and relative absence of unwanted side effects and because the clinician is present…
3. 生物統計学および疫学に関する一般用語集glossary of common biostatistical and epidemiological terms [show details]
…are reliability and validity. Reliability refers to the extent to which repeated measurements of a relatively stable phenomenon fall closely to each other. Several different types of reliability can… prescribed treatment, not just the effects on those who adhered to it. A drug which has serious side-effects but is highly effective, for example, might look favorable in an "as treated" analysis but less…
4. 米国の病院における医療の質の測定measuring quality in hospitals in the united states [show details]
… with pneumonia who received their first antibiotic dose within four hours of hospital arrival.… Reliability is a key determinant of the likelihood that a particular hospital will be misclassified as high or low performing strictly due to chance. As a general rule, the reliability of a hospital…
5. パーソナリティ障害の病理学的特徴を評価するためのディメンション方式・カテゴリー方式のハイブリッド型診断評価法dimensional categorical approach to assessing personality disorder pathology [show details]
…highly reliable: In a reliability study of module I of the Structured Clinical Interview for the DSM-5 Alternative Model of Personality Disorders in Norway, interrater reliability of the four LPFS domains …

English Journal

Determination of kansuiphorin C and kansuinin A in rat feces using UFLC-MS/MS and its application in the comparative excretion study on normal and malignant ascites rats.

Zhang Y, Lou JW, Zhang Q, Li ZL, Bao BH, Cao YD, Yao WF, Tang YP, Zhang L.
Journal of pharmaceutical and biomedical analysis. 2019 Jun;170()254-263.
Malignant ascites (MA) is one of the severe complications of gastrointestinal tumors, affecting the patients' survival time and quality of life. Euphorbia kansui is a commonly used toxic Chinese herbal medicine for malignant ascites. Our previous study showed that the biological and toxicological ef
PMID 30947126

Limitations of pesticide genotoxicity testing using the bacterial in vitro method.

Ilyushina N, Egorova O, Rakitskii V.
Toxicology in vitro : an international journal published in association with BIBRA. 2019 Jun;57()110-116.
The results of genotoxicity assessment of 115 technical grade pesticide products (61 names) with the Ames test and mammalian erythrocyte micronucleus test in vivo are presented. In most cases, unidirectional results were found. However, some pesticides belonging to classes of neonicotinoids, derivat
PMID 30807808

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001-2018.

Al-Jaal BA, Jaganjac M, Barcaru A, Horvatovich P, Latiff A.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Apr;129()211-228.
Human exposure to mycotoxins occurs mostly through dietary intake, although exposure through dermal and inhalation routes has also been shown. Depending on the type of mycotoxins, the applied dose and duration of exposure, a particular toxin can cause either chronic or acute illnesses such as kidney
PMID 31034935

Japanese Journal

Effects of Oridonin on Hepatic Cytochrome P450 Expression and Activities in PXR-Humanized Mice

Zhang Yi-wen,Bao Mei-hua,Lou Xiao-ya,Cheng Yu,Yu Jing,Zhou Hong-hao
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 41(5), 707-712, 2018
… Therefore, this study has employed more reliable models PXR-humanized mouse to investigate the influence of oridonin on PXR and downstream metabolism enzyme. … The effects of oridonin on major downstream CYPs of PXR were examined at both the mRNA and enzyme activity levels by RT-PCR and HPLC-MS/MS. In general, there was no significant toxic reaction in liver of PXR-humanized mice. …
NAID 130006730738

A FURTHER STUDY ON THE RELIABILITY OF TOXICOKINETIC PARAMETERS FOR PREDICTING HEPATOTOXICITY IN RATS RECEIVING A 28-DAY REPEATED ADMINISTRATION OF DDT

Tomiyama Naruto,Takeda Makio,Watanabe Momiko [他],KOBAYASHI Hiroko,HARADA Takanori
Journal of toxicological sciences 29(5), 505-516, 2004-12-27
… DDT (T-DDT) in plasma and liver of rats in a 7-day repeated dose study at 1000 ppm To confirm the reliability of AUC for predicting toxic responses at different dose levels, we conducted a further 28-day repeated dose study of p, p'-DDT in male F344 rats at dietary levels of 50, 160, and 500 ppm Concentrations of DDT and its metabolites in plasma, brain, liver, and fat for each dose group were measured at various time intervals during the study …
NAID 130000065387

A COMPARATIVE STUDY ON THE RELIABLILITY OF TOXICOKINETIC PARAMETERS FOR PREDICTING HEPATOTOXICITY OF DDT IN RATS RECEIVING A SINGLE OR REPEATED ADMINISTRATION

Tomiyama Naruto,Watanabe Momiko,Takeda Makio [他],HARADA Takanori,KOBAYASHI Hiroko
Journal of toxicological sciences 28(5), 403-413, 2003-12-26
… Increases in the absolute and relative (ratio to body weight) liver weights were observed as a typical toxic response after a single or repeated exposure to DDT. … between the relative liver weight and AUC of DDT or the total DDT (T-DDT) in the plasma and liver were found to be more consistent and higher than those with their concentrations in the repeated dose study. … values in correlation with their AUCs after a single exposure were lower than those in the repeated dose study. …
NAID 110001802905