recombinant human acid alpha-glucosidase

組換え型ヒト酸性αグルコシダーゼ

関

alglucosidase alfa、human acid alpha-glucosidase、rhGAA

WordNet

1. sing with closed lips; "She hummed a melody"
2. a humming noise; "the hum of distant traffic" (同)humming
3. be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
4. sound with a monotonous hum (同)thrum
5. make a low continuous sound; "The refrigerator is humming"
6. relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
7. characteristic of humanity; "human nature"
8. having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"
9. first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
10. the 1st letter of the Greek alphabet
11. the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
12. early testing stage of a software or hardware product; "alpha version"
13. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
14. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
15. having the characteristics of an acid; "an acid reaction"
16. of or relating to recombinant DNA
17. a cell or organism in which genetic recombination has occurred

PrepTutorEJDIC

1. 〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
2. (動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類
3. アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
4. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
5. 遺伝子の新結合による

UpToDate Contents

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• 1. Lysosomal acid alpha-glucosidase deficiency (Pompe disease, glycogen storage disease II, acid maltase deficiency)
• 2. グリコーゲン脱分枝酵素欠損症（糖原病III型） glycogen debrancher deficiency glycogen storage disease iii
• 3. 糖尿病の治療におけるα-グルコシダーゼ阻害剤およびリパーゼ阻害剤 alpha glucosidase inhibitors and lipase inhibitors for treatment of diabetes mellitus
• 4. 2型糖尿病における持続性高血糖のマネージメント management of persistent hyperglycemia in type 2 diabetes mellitus
• 5. 2型糖尿病の予防 prevention of type 2 diabetes mellitus

English Journal

• Long-Term Prognosis of Patients with Infantile-Onset Pompe Disease Diagnosed by Newborn Screening and Treated since Birth.

• Chien YH1, Lee NC1, Chen CA2, Tsai FJ3, Tsai WH4, Shieh JY5, Huang HJ6, Hsu WC7, Tsai TH8, Hwu WL9.
• The Journal of pediatrics.J Pediatr.2014 Nov 4. pii: S0022-3476(14)01035-X. doi: 10.1016/j.jpeds.2014.10.068. [Epub ahead of print]
• OBJECTIVE: To determine the benefit of newborn screening for the long-term prognosis of patients with classic infantile-onset Pompe disease (IOPD).STUDY DESIGN: A cohort of patients with classic IOPD were diagnosed by newborn screening, treated with recombinant human acid α-glucosidase (rhGAA), and
• PMID 25466677

• Transient low-dose methotrexate generates B regulatory cells that mediate antigen-specific tolerance to alglucosidase alfa.

• Joly MS1, Martin RP1, Mitra-Kaushik S1, Phillips L1, D'Angona A1, Richards SM1, Joseph AM2.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Oct 15;193(8):3947-58. doi: 10.4049/jimmunol.1303326. Epub 2014 Sep 10.
• Biologic drugs, including enzyme-replacement therapies, can elicit anti-drug Abs (ADA) that may interfere with drug efficacy and impact patient safety. In an effort to control ADA, we focused on identifying regimens of immune tolerance induction that may be readily available for clinical use. Data g
• PMID 25210119

• New therapeutic approaches for Pompe disease: enzyme replacement therapy and beyond.

• Kishnani PS, Beckemeyer AA.
• Pediatric endocrinology reviews : PER.Pediatr Endocrinol Rev.2014 Sep;12 Suppl 1:114-24.
• Pompe disease is an autosomal recessive disorder of glycogen metabolism caused by a deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). Prior to 2006, therapy was palliative. Severely affected infants with Pompe succumbed to cardiomyopathy or respiratory failure by one year of age. Enzy
• PMID 25345093

Japanese Journal

• Recombinant human acid alpha-glucosidase enzyme therapy for infantile glycogen storage disease type II : results of a phase I/II clinical trial

• AMALFITANO A
• Genet Med 3, 132-138, 2001
• NAID 30009278176

• Recombinant human acid alpha-glucosidase : high level production in mouse milk. biochemical characteristics. correction of enzyme deficiency in GSDII KO mice

• BIJVOET AGA.
• Hum MoI Genet 7, 1815-1824, 1998
• NAID 30018400636

Related Links

• Recombinant human acid [alpha]-glucosidase: major clinical ...

1. Neurology. 2007 Jan 9;68(2):99-109. Epub 2006 Dec 6. Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Kishnani PS, Corzo D, Nicolino M, Byrne B, Mandel H, Hwu WL, Leslie ...

• European Medicines Agency - Human medicines - EU/3/01/018

Product details for <p>Recombinant human acid alpha-glucosidase</p> Active substance Recombinant human acid alpha-glucosidase Medicine Name Myozyme Disease/condition Treatment of glycogen storage disease type II ...

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★リンクテーブル★

リンク元	「rhGAA」「組換え型ヒト酸性αグルコシダーゼ」「alglucosidase alfa」「human acid alpha-glucosidase」
関連記事	「human」「recombinant」「alpha」

「rhGAA」

　　[★]

• 組換え型ヒト酸性αグルコシダーゼ

関

alglucosidase alfa、human acid alpha-glucosidase、recombinant human acid alpha-glucosidase

「組換え型ヒト酸性αグルコシダーゼ」

　　[★]

英

recombinant human acid alpha-glucosidase、rhGAA

関

アルグルコシダーゼアルファ、ヒト酸性αグルコシダーゼ

「alglucosidase alfa」

　　[★]

アルグルコシダーゼアルファ

関

human acid alpha-glucosidase、recombinant human acid alpha-glucosidase、rhGAA

「human acid alpha-glucosidase」

　　[★]

ヒト酸性αグルコシダーゼ

関

alglucosidase alfa、recombinant human acid alpha-glucosidase、rhGAA

「human」

　　[★]

• n.

• ヒト

• adj.

• ヒトの、ヒト型の

関

ape、hominid、Hominidae、homo、Homo sapiens、human being、human race、human-type、man、Pongidae

　 　 　 　

「recombinant」

　　[★]

• adj.

• 組換え型の

• n.

• 組換え体、リコンビナント

関

recombinantly、recombination、recombinational、recombinogenic

　 　 　

「alpha」

　　[★]

α、アルファ

関

alfa