癌原遺伝子産物c-Akt
WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- in favor of a proposition, opinion, etc.
- an argument in favor of a proposal
- in favor of (an action or proposal etc.); "a pro vote"
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- indicating the first or earliest or original; "`proto is a combining form in a word like `protolanguage that refers to the hypothetical ancestor of another language or group of languages"
PrepTutorEJDIC
- carbonの化学記号
- =professional
- 賛成論;賛成票(者) / 賛成して
- 蛋白(たんばく)質
- answer / ampere
UpToDate Contents
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English Journal
- Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones.
- Cavazzoni A, Bonelli MA, Fumarola C, La Monica S, Airoud K, Bertoni R, Alfieri RR, Galetti M, Tramonti S, Galvani E, Harris AL, Martin LA, Andreis D, Bottini A, Generali D, Petronini PG.SourceDepartment of Experimental Medicine, Unit of Experimental Oncology, University of Parma, Italy.
- Cancer letters.Cancer Lett.2012 Oct 1;323(1):77-87. Epub 2012 Apr 3.
- Development of resistance to endocrine therapy is a clinical issue in estrogen receptor (ER)-positive breast cancer. Here we show that persistent activation of AKT/mTOR signaling is crucial to the acquisition of letrozole resistance in cell clones generated from MCF-7/AROM-1 aromatase-expressing bre
- PMID 22484466
- Gambogenic acid induces G1 arrest via GSK3β-dependent cyclin D1 degradation and triggers autophagy in lung cancer cells.
- Yu XJ, Han QB, Wen ZS, Ma L, Gao J, Zhou GB.SourceDivision of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
- Cancer letters.Cancer Lett.2012 Sep 28;322(2):185-94. Epub 2012 Mar 9.
- Cyclin D1, an oncogenic G1 cyclin which can be induced by environmental carcinogens and whose over-expression may cause dysplasia and carcinoma, has been shown to be a target for cancer chemoprevention and therapy. In this study, we investigated the effects and underlying mechanisms of action of a p
- PMID 22410463
Related Links
- Data indicate a link between proto-oncogene protein c-akt (AKT) mediated glycolytic metabolism and autophagy in the activated macrophages. Our study identified Akt1 as a novel target for the treatment of interstitial lung disease ...
- 1. Biochem J. 1998 Oct 1;335 ( Pt 1):1-13. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Coffer PJ(1), Jin J, Woodgett JR. Author information: (1)Department of Pulmonary ...
★リンクテーブル★
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- 英
- proto-oncogene protein c-Akt
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- 同
- Akt protein、Aktタンパク質
- Aktはアポトーシスを妨げ細胞周期をすすめるタンパク質をリン酸化。
- mTORと(mTORの標的である)p70S6kは細胞の増殖を促すタンパクの合成を亢進する。
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- 関
- oncogene product、oncoprotein
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