WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
PrepTutorEJDIC
- 蛋白(たんばく)質
- answer / ampere
UpToDate Contents
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English Journal
- PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.
- Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ.SourceKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education; Shanghai Jiao Tong University School of Medicine (SJTU-SM); Shanghai, China.
- Autophagy.Autophagy.2011 Oct 1;7(10). [Epub ahead of print]
- Autophagy is a highly conserved, closely regulated homeostatic cellular activity that allows for the bulk degradation of long-lived proteins and cytoplasmic organelles. Its roles in cancer initiation and progression and in determining the response of tumor cells to anticancer therapy are complicated
- PMID 21673516
Japanese Journal
- Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells
- Sugimoto Naotoshi,Miwa Shinji,Ohno-Shosaku Takako,Tsuchiya Hiroyuki,Hitomi Yoshiaki,Nakamura Hiroyuki,Tomita Katsuro,Yachie Akihiro,Koizumi Shoichi
- Neuroscience Letters 497(1), 55-59, 2011-06-15
- … Tumor suppressor protein phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a lipid phosphatase that inhibits the phosphoinositide 3-kinase (PI3K) pathway. … The phosphorylation of Akt, which is one of the key molecules downstream of PI3K, inhibits apoptosis. … Both cAMP stimulatory agents induced marked morphological changes in the cells, decreased cell number, decreased Akt phosphorylation, activated PTEN, cleaved caspase-3, and induced the condensation and fragmentation of nuclei. …
- NAID 120003141599
Related Links
- The phosphatases in the PHLPP family, PHLPP1 and PHLPP2 have been shown to directly de-phosphorylate, and therefore inactivate, distinct Akt isoforms. PHLPP2 dephosphorylates Akt1 and Akt3, ...
Related Pictures
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- 同
- Akt protein、Aktタンパク質
- Aktはアポトーシスを妨げ細胞周期をすすめるタンパク質をリン酸化。
- mTORと(mTORの標的である)p70S6kは細胞の増殖を促すタンパクの合成を亢進する。
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