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Contribution of domain 30 of tropoelastin to elastic fiber formation and material elasticity.

Muiznieks LD1, Miao M1, Sitarz EE1, Keeley FW1,2,3.
Biopolymers.Biopolymers.2016 May;105(5):267-75. doi: 10.1002/bip.22804.
Elastin is a fibrous structural protein of the extracellular matrix that provides reversible elastic recoil to vertebrate tissues such as arterial vessels, lung, and skin. The elastin monomer, tropoelastin, contains a large proportion of intrinsically disordered and flexible hydrophobic sequences th
PMID 26763595

NMR chemical shift analysis of the conformational transition between the monomer and tetramer of melittin in an aqueous solution.

Miura Y1.
European biophysics journal : EBJ.Eur Biophys J.2016 May;45(4):347-54. doi: 10.1007/s00249-015-1102-1. Epub 2015 Dec 11.
It is known that melittin in an aqueous solution undergoes a conformational transition between the monomer and tetramer by variation in temperature. The transition correlates closely with isomers of the proline residue; monomeric melittin including a trans proline peptide bond (trans-monomer) is inv
PMID 26658745

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.

Hegemann JD1, Fage CD, Zhu S, Harms K, Di Leva FS, Novellino E, Marinelli L, Marahiel MA.
Molecular bioSystems.Mol Biosyst.2016 Apr 22;12(4):1106-9. doi: 10.1039/c6mb00081a. Epub 2016 Feb 11.
Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulation
PMID 26863937

Mutation for Nonsyndromic Mental Retardation in the trans-2-Enoyl-CoA Reductase TER Gene Involved in Fatty Acid Elongation Impairs the Enzyme Activity and Stability, Leading to Change in Sphingolipid Profile

Abe Kensuke,Ohno Yusuke,Sassa Takayuki,Taguchi Ryo,Caliskan Minal,Ober Carole,Kihara Akio
Journal of biological chemistry 288(51), 36741-36749, 2013-12-20
… This mutation substitutes a leucine for a proline residue at amino acid 182 in the TER enzyme. …
NAID 120005385316

松本歯学 38(1), 1-11, 2012-04-30
… This enzyme was found only in cell extract and active on tripeptide substrates containing proline residue at P1 position, particularly H−Ala−Ala−Pro−p−nitroanilide. …
NAID 80022678550

Functional Analysis of the C-Terminal Region of γ-Glutamyl Kinase of Saccharomyces cerevisiae

KAINO Tomohiro,TASAKA Yumi,TATEHASHI Yuki [他],TAKAGI Hiroshi
Bioscience, biotechnology, and biochemistry 76(3), 454-461, 2012-03-23
… γ-Glutamyl kinase (GK) is the rate-limiting enzyme in proline synthesis in microorganisms. … and enzymatic analysis of recombinant proteins revealed that a 67-residue linker sequence between a 255-residue kinase domain and a 106-residue PUA domain is essential for GK activity. …
NAID 10030750315