プロカインペニシリンG
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- Crysticillin
WordNet
- a white crystalline powder (trade name Ethocaine) administered near nerves as a local anesthetic in dentistry and medicine (同)Ethocaine
- any of various antibiotics obtained from Penicillium molds (or produced synthetically) and used in the treatment of various infections and diseases
- a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated (同)gee, g-force
- the 7th letter of the Roman alphabet (同)g
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/12 07:37:53」(JST)
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Procaine benzylpenicillin
| Combination of |
| Benzylpenicillin |
antibiotic |
| Procaine |
anaesthetic |
| Clinical data |
| AHFS/Drugs.com |
monograph |
| Legal status |
|
| Identifiers |
| CAS number |
54-35-3 Y |
| ATC code |
J01CE09 QJ51CE09 |
| ChEMBL |
CHEMBL1628385 N |
| N (what is this?) (verify) |
Procaine benzylpenicillin (rINN), also known as procaine penicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
It is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, it is slowly absorbed into the circulation and hydrolysed to benzylpenicillin — thus it is used where prolonged low concentrations of benzylpenicillin are required.
This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]
Contents
- 1 Uses
- 2 Adverse effects
- 3 Compendial status
- 4 References
Uses
Specific indications for procaine penicillin include:[2]
- Syphilis
- In the United States, Bicillin C-R (a injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, since it contains only half the recommended dose of benzathine penicillin. Medication errors have been made due to the confusion between Bicillin L-A & Bicillin C-R.[3] As a result, changes in product packaging have been made; specifically, the statement "Not for the Treatment of Syphilis" has been added in red text to both the Bicillin CR and Billin CR 900/300 syringe labels.[4]
- Respiratory tract infections where compliance with oral treatment is unlikely
- Alongside Pen V and Erythromycin, Bicillin C-R is used to treat strep throat, given as one IM injection
- Cellulitis, erysipelas
- Procaine penicillin is also used as an adjunct in the treatment of anthrax.
Adverse effects
Further information: Penicillin drug reaction
At high doses procaine penicillin can cause seizures and CNS abnormalities due to procaine present in it.
Compendial status
- British Pharmacopoeia [5]
References
- ^ "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014.
- ^ Rossi S, editor, ed. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook. ISBN 0-9757919-2-3.
- ^ Centers for Disease Control and Prevention (CDC) (2005). "Inadvertent use of Bicillin C-R to treat syphilis infection—Los Angeles, California, 1999–2004". MMWR Morb. Mortal. Wkly. Rep. 54 (9): 217–9. PMID 15758893.
- ^ United States Food & Drug Administration. "FDA Strengthens Labels of Two Specific Types of Antibiotics to Ensure Proper Use." Published December 1, 2004. Last accessed June 18, 2007.
- ^ British Pharmacopoeia Commission Secretariat. "Index (BP 2009)". Retrieved 26 March 2010.
|
Antibacterials: cell envelope antibiotics (J01C-J01D)
|
|
| Intracellular |
- inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
|
|
| Glycopeptide |
- inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
|
|
β-lactams/
(inhibit PBP
cross-links) |
|
Penicillins
(penams)
|
|
Extended sp.
|
- aminopenicillins: Amoxicillin#
- Ampicillin# (Pivampicillin
- Hetacillin
- Bacampicillin
- Metampicillin
- Talampicillin)
- Epicillin
- carboxypenicillins: Carbenicillin (Carindacillin)
- Ticarcillin
- Temocillin
- ureidopenicillins: Azlocillin
- Piperacillin
- Mezlocillin
- other: Mecillinam (Pivmecillinam)
- Sulbenicillin
|
|
|
Narrow sp.
|
|
β-lactamase sensitive
|
- Benzylpenicillin (G)#: Clometocillin
- Benzathine benzylpenicillin#
- Procaine benzylpenicillin#
- Azidocillin
- Penamecillin
- Phenoxymethylpenicillin (V)#: Propicillin
- Benzathine phenoxymethylpenicillin
- Pheneticillin
|
|
|
β-lactamase resistant
|
- Cloxacillin# (Dicloxacillin
- Flucloxacillin)
- Oxacillin
- Meticillin
- Nafcillin
|
|
|
|
|
Penems
|
|
|
|
Carbapenems
|
- Biapenem
- Ertapenem
- antipseudomonal (Doripenem
- Imipenem
- Meropenem)
- Panipenem
|
|
|
Cephalosporins/Cephamycins
(cephems)
|
|
1st (PEcK)
|
- Cefazolin#
- Cefacetrile
- Cefadroxil
- Cefalexin
- Cefaloglycin
- Cefalonium
- Cefaloridine
- Cefalotin
- Cefapirin
- Cefatrizine
- Cefazedone
- Cefazaflur
- Cefradine
- Cefroxadine
- Ceftezole
|
|
|
2nd (HEN)
|
- Cefaclor
- Cefamandole
- Cefminox
- Cefonicid
- Ceforanide
- Cefotiam
- Cefprozil
- Cefbuperazone
- Cefuroxime
- Cefuzonam
- cephamycin (Cefoxitin
- Cefotetan
- Cefmetazole)
- carbacephem (Loracarbef)
|
|
|
3rd
|
- Cefixime#
- Ceftriaxone#
- antipseudomonal (Ceftazidime#
- Cefoperazone)
- Cefcapene
- Cefdaloxime
- Cefdinir
- Cefditoren
- Cefetamet
- Cefmenoxime
- Cefodizime
- Cefotaxime
- Cefpimizole
- Cefpiramide
- Cefpodoxime
- Cefsulodin
- Cefteram
- Ceftibuten
- Ceftiolene
- Ceftizoxime
- oxacephem (Flomoxef
- Latamoxef ‡)
|
|
|
4th (antipseudomonal)
|
- Cefepime
- Cefozopran
- Cefpirome
- Cefquinome
|
|
|
5th
|
- Ceftobiprole
- Ceftaroline fosamil
- Ceftolozane
|
|
|
Veterinary
|
- Ceftiofur
- Cefquinome
- Cefovecin
|
|
|
|
Monobactams
|
- Aztreonam
- Tigemonam
- Carumonam
- Nocardicin A
|
|
|
β-lactamase inh.
|
- penam (Sulbactam
- Tazobactam)
- clavam (Clavulanic acid)
|
|
|
Combinations
|
- Amoxicillin/clavulanic acid#
- Imipenem/cilastatin#
- Ampicillin/flucloxacillin
- Ampicillin/sulbactam (Sultamicillin)
- Piperacillin/tazobactam
|
|
|
| Other |
- polymyxins/detergent (Colistin
- Polymyxin B)
- depolarizing (Daptomycin)
- hydrolyze NAM-NAG (lysozyme)
- Gramicidin
- Isoniazid
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
gr+f/gr+a (t)/gr-p (c)/gr-o
|
drug (J1p, w, n, m, vacc)
|
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Dizziness and rash in an HIV positive man.
- Bradshaw D, Nwokolo N.SourceChelsea and Westminster Hospital, London SW10 9NH, UK. dan.bradshaw@doctors.org.uk
- BMJ (Clinical research ed.).BMJ.2012 Jun 28;344:e4167. doi: 10.1136/bmj.e4167.
- PMID 22745326
- Effects of dietary supplementation of Chinese medicinal herbs on polymorphonuclear neutrophil immune activity and small intestinal morphology in weanling pigs.
- Huang CW, Lee TT, Shih YC, Yu B.SourceDepartment of Animal Science, National Chung Hsing University, Taichung, Taiwan, China.
- Journal of animal physiology and animal nutrition.J Anim Physiol Anim Nutr (Berl).2012 Apr;96(2):285-94. doi: 10.1111/j.1439-0396.2011.01151.x. Epub 2011 May 2.
- The purpose of this study was to evaluate the effects of dietary Chinese medicinal herbs (CMH) supplementation composed of Panax ginseng, Dioscoreaceae opposite, Atractylodes macrocephala, Glycyrrhiza uralensis, Ziziphus jujube and Platycodon grandiflorum, on the performance, intestinal tract morpho
- PMID 21535231
Japanese Journal
- X-Ray Powder Diffraction Patterns for Certain .BETA.-Lactam, Tetracycline and Macrolide Antibiotic Drugs
- THANGADURAI S.,ABRAHAM J. T.,SRIVASTAVA A. K.,NATARAJA MOORTHY M.,SHUKLA S. K.,ANJANEYULU Y.
- Analytical Sciences 21(7), 833-838, 2005
- … X-ray powder diffraction (XRD) data for eight β-lactam viz., ampicillin sodium, ampicillin trihydrate, penicillin G procaine, benzathine penicillin, benzyl penicillin sodium, cefalexin, cefotaxime sodium and ceftriaxone sodium; …
- NAID 130004441100
- Capillary electrophoresis method for simultaneous determination of penicillin G, procaine and dihydrostreptomycin in veterinary drugs
- MICHALSKA Katarzyna,PAJCHEL Genowefa,TYSKI Stefan
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 800(1), 203-209, 2004-02-05
- NAID 10016547535
- Relationship between Percentages of Cures and Antimicrobial Treatment of Clinical Coliform Mastitis among Cows at Livestock Clinics on Hokkaido
- 萩原 精一,岡田 洋之
- 日本獣医師会雑誌 57(3), 170-174, 2004
- … It was positively associated with the average number of intramammary injections of penicillin-G-procaine (300, 000 U) +dihydro-streptomycin (300mg)(r= 0.38, <I>P</I><0.01). …
- NAID 130003848450
Related Links
- Procaine penicillin G explanation. Information about Procaine penicillin G in Free online English dictionary. What is Procaine penicillin G? Meaning of Procaine penicillin G medical term. What does Procaine penicillin G mean? ...
- Learn about Procaine Penicillin G (Canada) for animal usage including: active ingredients, directions for use, precautions, and storage information. ... Drugs.com provides accurate and independent information on more than 24,000 ...
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