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1. 角膜剥離および角膜異物：マネージメントcorneal abrasions and corneal foreign bodies management [show details]
…The approach to treatment of corneal abrasions is summarized in the algorithm Treatment options vary based upon the subtype of corneal abrasion. Children with corneal abrasions are treated similarly to adults …
2. 視覚変化が認められた小児患者に対するアプローチapproach to the pediatric patient with vision change [show details]
… ahead (in primary position). The degree of esotropia and abduction deficit are markers of severity of the paresis or palsy. The ocular examination typically reveals a primary position esotropia… Inspection may show enophthalmos. Careful examination of the globe for associated injuries (eg, corneal abrasion, hyphema) is also necessary. Orbital cellulitis can present with double vision in the setting …
3. 角膜剥離および角膜異物：臨床症状および診断corneal abrasions and corneal foreign bodies clinical manifestations and diagnosis [show details]
…Spontaneous corneal abrasions are also known as recurrent erosions. Corneal abrasions are common, accounting for 8 to 13 percent of eye presentations, depending upon the setting (eg, primary care offices …
4. 持続性の流涙がみられる小児に対するアプローチapproach to the child with persistent tearing [show details]
…are under the upper eyelid may cause vertically oriented linear corneal abrasions. Fluorescein examination may reveal the corneal abrasions; the foreign body is viewed either directly or with the slit lamp …
5. コンタクトレンズの合併症complications of contact lenses [show details]
… nearly one-third had experienced a contact lens-related condition that required a doctor visit . Primary care and emergency department clinicians are often the first to evaluate patients with contact lens-related … Corneal abrasions should be treated with topical antibiotics with pseudomonal coverage and removal of the contact lens. We recommend not patching the eye for small (<10 mm) corneal abrasions .…

English Journal

Quantitative proteomic analysis of human corneal epithelial cells infected with HSV-1.

Cui YH, Liu Q, Xu ZY, Li JH, Hu ZX, Li MJ, Zheng WL, Li ZJ, Pan HW.
Experimental eye research. 2019 May;().
HSV-1 infection in corneal epithelium initiates the process of herpes simplex keratitis. We investigated the dynamic change of the host proteins in corneal epithelial cells infected with HSV-1 to understand the virus-host interaction. iTRAQ coupled with LC-MS/MS was applied to quantitatively analyze
PMID 31085182

The US11 Gene of Herpes Simplex Virus 1 Promotes Neuroinvasion and Periocular Replication following Corneal Infection.

Charron AJ, Ward SL, North BJ, Ceron S, Leib DA.
Journal of virology. 2019 May;93(9).
Herpes simplex virus 1 (HSV-1) cycles between phases of latency in sensory neurons and replication in mucosal sites. HSV-1 encodes two key proteins that antagonize the shutdown of host translation, US11 through preventing PKR activation and ICP34.5 through mediating dephosphorylation of the α subun
PMID 30760571

Topical Tacrolimus for Chronic Allergic Conjunctival Disease with and without Atopic Dermatitis.

Shoji J, Ohashi Y, Fukushima A, Miyazaki D, Uchio E, Takamura E, Fujishima H, Namba K, Kumagai N, Ebihara N, Okamoto S.
Current eye research. 2019 Apr;()1-10.
Purpose/Aim: This study evaluated the efficacy of topical 0.1% tacrolimus ophthalmic suspension for treating chronic allergic conjunctival disease with and without atopic dermatitis. This study was conducted as a prospective observational post-market survey. Our large-scale study protocol was accept
PMID 30947551

Japanese Journal

Successful primary culture and autologous transplantation of corneal limbal epithelial cells from minimal biopsy for unilateral severe ocular surface disease