WordNet

born after a gestation period of less than the normal time; "a premature infant"
uncommonly early or before the expected time; "illness led to his premature death"; "alcohol brought him to an untimely end" (同)untimely
the state of being depleted
the act of decreasing something markedly
of or relating to or constituting a follicle

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1. 原発性早期卵巣障害（早期卵巣機能不全）の病因と原因 pathogenesis and causes of spontaneous primary ovarian insufficiency premature ovarian failure
2. 早期副腎皮質性第二次性徴 premature adrenarche
3. 濾胞性リンパ腫の臨床症状、病理学的特徴、診断、および予後 clinical manifestations pathologic features diagnosis and prognosis of follicular lymphoma
4. 心室性期外収縮 ventricular premature beats
5. 自発性早期卵巣障害（早期卵巣機能不全）の臨床症状および評価 clinical manifestations and evaluation of spontaneous primary ovarian insufficiency premature ovarian failure

Pharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signaling.

Adhikari D, Risal S, Liu K, Shen Y.SourceDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden. deepak.adhikari@medchem.umu.se
PloS one.PLoS One.2013;8(1):e53810. doi: 10.1371/journal.pone.0053810. Epub 2013 Jan 11.
The majority of ovarian primordial follicles must be preserved in a quiescent state to allow for the regular production of gametes over the female reproductive lifespan. However, the molecular mechanism that maintains the long quiescence of primordial follicles is poorly understood. Under certain pa
PMID 23326514

Targeted loss of androgen receptor signaling in murine granulosa cells of preantral and antral follicles causes female subfertility.

Walters KA, Middleton LJ, Joseph SR, Hazra R, Jimenez M, Simanainen U, Allan CM, Handelsman DJ.SourceANZAC Research Institute, Department of Andrology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia. kwalters@anzac.edu.au
Biology of reproduction.Biol Reprod.2012 Dec 27;87(6):151. doi: 10.1095/biolreprod.112.102012. Print 2012 Jun.
Ovarian granulosa cells display strong androgen receptor (AR) expression, suggesting a functional role for direct AR-mediated actions within developing mammalian follicles. By crossing AR-floxed and anti-Müllerian hormone (AMH)-Cre recombinase mice, we generated granulosa cell-specific androgen rec
PMID 23115271

Zschemisch NH, Glage S, Wedekind D, Weinstein EJ, Cui X, Dorsch M, Hedrich HJ.SourceInstitute of Laboratory Animal Science, Hannover Medical School, Carl-Neuberg-Str,1, 30625, Hannover, Germany. Zschemisch.Nils-Holger@mh-hannover.de
BMC immunology.BMC Immunol.2012 Nov 8;13:60. doi: 10.1186/1471-2172-13-60.
BACKGROUND: Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or cytoplasmatic microinjection into zygotes. Result
PMID 23136839