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a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19

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ポタシウム,カリウム(金属元素;化学記号はK)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/24 14:07:34」(JST)

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Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.^[1] Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body. Potassium canrenoate is not licensed in the UK, but may sometimes be prescribed off-licence to treat oedema. It is given intravenously.

References

^ R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991). Dictionary of Steroids. CRC Press. pp. 656–. ISBN 978-0-412-27060-4.

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English Journal

Microvascular responses to aldosterone in hamster cheek pouch microcirculation.

Lapi D, Emdin M, Mastantuono T, Sapio D, Santillo M, Colantuoni A.SourceDepartment of Neuroscience, "Federico II" University Medical School, Naples, Italy.
Clinical hemorheology and microcirculation.Clin Hemorheol Microcirc.2012 May 16. [Epub ahead of print]
The aim of the present study was to assess the in vivo effects of aldosterone topically applied on the hamster cheek pouch microcirculation under baseline conditions or during ischemia- reperfusion. Male Syrian hamsters were anesthetized, tracheotomized and intubated. They were studied under baselin
PMID 22596229

Japanese Journal

Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model

SUGIYAMA Atsushi,SATOH Yoshioki,TAKAHARA Akira,ANDO Kentaro,WANG Kai,HONSHO Sachiko,NAKAMURA Yuji,HASHIMOTO Keitaro
Journal of pharmacological sciences 96(4), 436-443, 2004-12-01
… In this study, we examined in vivo electropharmacological effects of an active derivative of spironolactone, potassium canrenoate, using a halothane-anesthetized canine model. … Potassium canrenoate was intravenously administered in three doses of 1, 10, and 100 mg/kg per 10 min with a pause of 20 min between doses (n = 5). …
NAID 10014075829

Related Pictures

★リンクテーブル★

リンク元	「カンレノ酸」「カンレノン酸カリウム」「canrenoate potassium」

「カンレノ酸」

Potassium canrenoate
Systematic (IUPAC) name
	potassium 3-[(8R,9S,10R,13S,14S,17R)-; 17-hydroxy-10,13-dimethyl-3-oxo-2,8,9,; 11,12,14,15,16-octahydro-1H-cyclopenta[a]; phenanthren-17-yl]propanoate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Intravenous
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal and fecal
Identifiers
CAS Number	2181-04-6
ATC code	C03DA02
PubChem	CID: 656614
DrugBank	DB09015
ChemSpider	570975
UNII	M671F9NLEA
ChEMBL	CHEMBL1371200
Synonyms	SC-14266
Chemical data
Formula	C22H29KO4
Molecular mass	396.5616 g/mol
	SMILES [K+].[O-]C(=O)CC[C@]3(O)CC[C@H]2[C@@H]4/C=C\C1=C\C(=O)CC[C@@]1([C@H]4CC[C@@]23C)C ;
	InChI InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1 ; Key:JTZQCHFUGHIPDF-RYVBEKKQSA-M ;
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英: canrenoate
化: カンレノン酸カリウム, potassium canrenoate、canrenoate potassium
同: ソルダクトン、ベネクトミン
関: 利尿薬

「カンレノン酸カリウム」

　　[★]

英: potassium canrenoate
関: カンレノ酸カリウム

「canrenoate potassium」

　　[★]

カンレノ酸カリウム

関: potassium canrenoate

[HillMakin1991-1] R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991). Dictionary of Steroids. CRC Press. pp. 656–. ISBN 978-0-412-27060-4.

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potassium canrenoate