Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?
Sansoè G1, Aragno M2, Mastrocola R2, Parola M2.
Clinical science (London, England : 1979).Clin Sci (Lond).2016 Jan 1;130(2):117-24. doi: 10.1042/CS20150479. Epub 2015 Oct 30.
Catecholamines trigger proximal tubular fluid retention and reduce renal excretion of solute-free water. In advanced cirrhosis, non-osmotic hypersecretion of vasopressin (antidiuretic hormone or ADH) is considered the cause of dilutional hyponatraemia, but ADH V2 receptor antagonists are not benefic
The Journal of investigative dermatology.J Invest Dermatol.2015 Jul;135(7):1781-9. doi: 10.1038/jid.2015.44. Epub 2015 Feb 10.
A major deleterious side effect of glucocorticoids is skin atrophy. Glucocorticoids activate the glucocorticoid and the mineralocorticoid (MR) receptor, both present in the epidermis. We hypothesized that glucocorticoid-induced epidermal atrophy may be related to inappropriate occupancy of MR by glu
Dose-dependency of clonidine's effects in ascitic cirrhotic rats: comparison with α1-adrenergic agonist midodrine.
Sansoè G1, Aragno M2, Mastrocola R2, Parola M2.
Liver international : official journal of the International Association for the Study of the Liver.Liver Int.2015 Jun 30. doi: 10.1111/liv.12905. [Epub ahead of print]
BACKGROUND & AIMS: Sympathetic nervous system (SNS) activation decreases response to diuretics, but both α1-adrenoceptor agonists and sympatholytic α2-adrenoceptor agonists are recommended in the management of ascitic cirrhosis. We intend to compare the effects of increasing doses of clonidine
Journal of pharmacological sciences 96(4), 436-443, 2004-12-01
… In this study, we examined in vivo electropharmacological effects of an active derivative of spironolactone, potassium canrenoate, using a halothane-anesthetized canine model. … Potassium canrenoate was intravenously administered in three doses of 1, 10, and 100 mg/kg per 10 min with a pause of 20 min between doses (n = 5). …
OE-275 A Spironolactone Derivative, Potassium Canrenoate, Prolongs the QT Interval but Shortens the Electrically Vulnerable Period of In Vivo Canine Hearts(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
… We examined the compatibility of a commercialized potassium canrenoate preparation (Soldactone^[○!R]) with 124 other kinds of currently prescribed injectable preparations as counter substances based upon the physico chemical parameters : actually, the appearance, pH, and the concentration of canrenoate were used as markers after mixing for 24 hours with other injectable preparations, since appearances can be deceptive. …
... performance liquid chromatography (HPLC) and fluorometry after oral administration of spironolactone (I) and potassium canrenoate (II) to human subjects. comparison of both assays for III in plasma as well as in urine after ...
Potassium Canrenoate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Potassium Canrenoate is available on the Drugs.com website. ... Drugs.com provides accurate and ...