pIgR

• 多量体免疫グロブリン受容体

関

polymeric immunoglobulin receptor

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/28 08:32:56」(JST)

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Polymeric immunoglobulin receptor
PDB rendering based on 1xed.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1XED, 2OCW, 3CHN, 3CM9
Identifiers
Symbols	PIGR; FLJ22667; MGC125361; MGC125362
External IDs	OMIM: 173880 MGI: 103080 HomoloGene: 1984 GeneCards: PIGR Gene
Gene Ontology Molecular function • protein binding Cellular component • extracellular region • integral to plasma membrane Biological process • protein secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5284	18703
Ensembl	ENSG00000162896	ENSMUSG00000026417
UniProt	P01833	O70570
RefSeq (mRNA)	NM_002644	NM_011082
RefSeq (protein)	NP_002635	NP_035212
Location (UCSC)	Chr 1: 207.1 – 207.12 Mb	Chr 1: 130.83 – 130.85 Mb
PubMed search	[1]	[2]

Polymeric immunoglobulin receptor is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which facilitates the secretion of immunoglobulin A and immunoglobulin M.

The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily (Hood et al., 1985). The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions.[supplied by OMIM]

References

Further reading

• Kaetzel CS (2005). "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces.". Immunol. Rev. 206: 83–99. doi:10.1111/j.0105-2896.2005.00278.x. PMID 16048543. 
• Krajci P, Kvale D, Taskén K, Brandtzaeg P (1992). "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)". Eur. J. Immunol. 22 (9): 2309–15. doi:10.1002/eji.1830220920. PMID 1355431. 
• Krajci P, Grzeschik KH, Geurts van Kessel AH, et al. (1991). "The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization.". Hum. Genet. 87 (6): 642–8. doi:10.1007/BF00201717. PMID 1682231. 
• Eiffert H, Quentin E, Wiederhold M, et al. (1991). "Determination of the molecular structure of the human free secretory component.". Biol. Chem. Hoppe-Seyler 372 (2): 119–28. doi:10.1515/bchm3.1991.372.1.119. PMID 1859628. 
• Bakos MA, Kurosky A, Goldblum RM (1991). "Characterization of a critical binding site for human polymeric Ig on secretory component". J. Immunol. 147 (10): 3419–26. PMID 1940346. 
• Krajci P, Solberg R, Sandberg M, et al. (1989). "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues". Biochem. Biophys. Res. Commun. 158 (3): 783–9. doi:10.1016/0006-291X(89)92790-3. PMID 2920039. 
• Davidson MK, Le Beau MM, Eddy RL, et al. (1989). "Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31----q41". Cytogenet. Cell Genet. 48 (2): 107–11. doi:10.1159/000132601. PMID 3197448. 
• Hood L, Kronenberg M, Hunkapiller T (1985). "T cell antigen receptors and the immunoglobulin supergene family". Cell 40 (2): 225–9. doi:10.1016/0092-8674(85)90133-3. PMID 3917857. 
• Eiffert H, Quentin E, Decker J, et al. (1985). "[The primary structure of human free secretory component and the arrangement of disulfide bonds]". Hoppe-Seyler's Z. Physiol. Chem. 365 (12): 1489–95. PMID 6526384. 
• Mizoguchi A, Mizuochi T, Kobata A (1982). "Structures of the carbohydrate moieties of secretory component purified from human milk". J. Biol. Chem. 257 (16): 9612–21. PMID 7107583. 
• Coyne RS, Siebrecht M, Peitsch MC, Casanova JE (1995). "Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I". J. Biol. Chem. 269 (50): 31620–5. PMID 7989333. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Piskurich JF, France JA, Tamer CM, et al. (1993). "Interferon-gamma induces polymeric immunoglobulin receptor mRNA in human intestinal epithelial cells by a protein synthesis dependent mechanism". Mol. Immunol. 30 (4): 413–21. doi:10.1016/0161-5890(93)90071-I. PMID 8455639. 
• Piskurich JF, Youngman KR, Phillips KM, et al. (1997). "Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon-gamma". Mol. Immunol. 34 (1): 75–91. doi:10.1016/S0161-5890(96)00079-X. PMID 9182878. 
• Hughes GJ, Frutiger S, Savoy LA, et al. (1997). "Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor". FEBS Lett. 410 (2–3): 443–6. doi:10.1016/S0014-5793(97)00629-7. PMID 9237679. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Ackermann LW, Wollenweber LA, Denning GM (1999). "IL-4 and IFN-gamma increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells". J. Immunol. 162 (9): 5112–8. PMID 10227981. 
• Røe M, Norderhaug IN, Brandtzaeg P, Johansen FE (1999). "Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction". J. Immunol. 162 (10): 6046–52. PMID 10229845. 
• Norderhaug IN, Johansen FE, Krajci P, Brandtzaeg P (1999). "Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interaction". European Journal of Immunology 29 (10): 3401–9. doi:10.1002/(SICI)1521-4141(199910)29:10<3401::AID-IMMU3401>3.0.CO;2-G. PMID 10540352. 
• Mostov KE, Friedlander M, Blobel G. (1984). "The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains". Nature 308 (5954): 37–43. doi:10.1038/308037a0. PMID 6322002. 
• Hughes GJ, Reason AJ, Savoy L, et al. (1999). "Carbohydrate moieties in human secretory component". Biochim. Biophys. Acta 1434 (1): 86–93. doi:10.1016/S0167-4838(99)00168-5. PMID 10556562. 

External links

• Polymeric Immunoglobulin Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 免疫グロブリンの構造 structure of immunoglobulins
• 2. IgGの構造および生物学的機能 structure and biologic functions of iga
• 3. 選択的IgA欠損症：臨床症状、病態生理、および診断 selective iga deficiency clinical manifestations pathophysiology and diagnosis
• 4. 原発性免疫不全の胃腸症状 gastrointestinal manifestations in primary immunodeficiency

English Journal

• Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma.

• Wang X, Du J, Gu P, Jin R, Lin X.
• Molecular medicine reports.Mol Med Rep.2014 Jun;9(6):2105-10. doi: 10.3892/mmr.2014.2110. Epub 2014 Apr 2.
• The prognosis of patients with osteosarcoma with distant metastasis and local recurrence remains poor. Increased expression of polymeric immunoglobulin receptor (pIgR) in tumor tissue has been detected in various types of cancer. However, the clinical significance of pIgR in osteosarcoma has yet to
• PMID 24699841

• Evaluation of Intra and Extraepitheilal Secretory IgA (SIgA) in Chlamydial Infections.

• Armitage CW1, O'Meara CP, Harvie MC, Timms P, Wijburg OL, Beagley KW.
• Immunology.Immunology.2014 May 14. doi: 10.1111/imm.12317. [Epub ahead of print]
• IgA is an important mucosal antibody that can neutralize mucosal pathogens by either preventing attachment to epithelia (immune exclusion) or alternatively inhibit intraepithelial replication following transcytosis by the polymeric immunoglobulin receptor (pIgR). Chlamydia trachomatis is a major hum
• PMID 24827556

• Intranasal coadministration of Cholera toxin with amoeba lysates modulates the secretion of IgA and IgG antibodies, production of cytokines and expression of pIgR in the nasal cavity of mice in the model of Naegleria fowleri meningoencephalitis.

• Carrasco-Yepez M1, Campos-Rodriguez R2, Lopez-Reyes I3, Bonilla-Lemus P1, Rodriguez-Cortes AY2, Contis-Montes de Oca A2, Jarillo-Luna A2, Miliar-Garcia A2, Rojas-Hernandez S4.
• Experimental parasitology.Exp Parasitol.2014 Apr 13. pii: S0014-4894(14)00091-5. doi: 10.1016/j.exppara.2014.04.002. [Epub ahead of print]
• The nasal mucosa is the first contact with antigens to induce IgA response. The role of this site has rarely been studied. We have shown than intranasal administration with Naegleria fowleri lysates plus Cholera toxin (CT) increased the protection (survival up to 100%) against N. fowleri infection i
• PMID 24731967

Japanese Journal

• 腸管免疫における上皮細胞の役割 (特集 腸管免疫の制御)

• 臨床免疫・アレルギー科 = Clinical immunology & allergology 64(4), 313-317, 2015-10
• NAID 40020622830

• The effects of moderate exercise on secretory IgA production in mice depends on dietary carbohydrate intake

• Journal of Clinical Biochemistry and Nutrition 57(1), 44-49, 2015
• NAID 130005085260

• The effects of moderate exercise on secretory IgA production in mice depends on dietary carbohydrate intake

• Journal of Clinical Biochemistry and Nutrition advpub(0), 2015
• NAID 130005074645

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polymeric immunoglobulin receptor pIgR

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多量体免疫グロブリンレセプター

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