pituitary ACTH hypersecretion

• 下垂体ACTH過剰分泌

関

Cushing disease

WordNet

1. of or relating to the pituitary gland; "pituitary hormone"
2. the master gland of the endocrine system; located at the base of the brain (同)pituitary_gland, pituitary body, hypophysis
3. excessive secretion

PrepTutorEJDIC

1. 脳下垂体の(から得られた) / =pituitary gland
2. American College Testing / Australian Capital Territory
3. 副腎皮質刺激ホルモン[剤]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/21 09:01:47」(JST)

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Pituitary ACTH hypersecretion
Classification and external resources
ICD-10	E24.0
ICD-9-CM	255.0
MeSH	D047748

Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.)

References

UpToDate Contents

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• 1. クッシング症候群の原因の特定 establishing the cause of cushings syndrome
• 2. クッシング症候群の治療の概要 overview of the treatment of cushings syndrome
• 3. Clinical manifestations and diagnosis of gonadotroph and other clinically nonfunctioning pituitary adenomas
• 4. クッシング病の一次治療：経蝶形骨洞手術および下垂体照射 primary therapy of cushings disease transsphenoidal surgery and pituitary irradiation
• 5. 鞍部腫瘤の原因、症状、および評価 causes presentation and evaluation of sellar masses

English Journal

• The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease.

• Hayashi K1, Inoshita N2, Kawaguchi K2, Ibrahim Ardisasmita A2, Suzuki H2, Fukuhara N2, Okada M2, Nishioka H1, Takeuchi Y1, Komada M2, Takeshita A1, Yamada S3.
• European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2016 Feb;174(2):213-26. doi: 10.1530/EJE-15-0689. Epub 2015 Nov 17.
• CONTEXT: Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently detected in one- to two-third(s) of corticotroph adenomas of Cushing's disease (CD). These mutations may lead to the deubiquitination of EGFR, thereby increasing EGFR signaling, which has been implicated in ACTH h
• PMID 26578638

• High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease.

• de Rotte AA1, Groenewegen A2, Rutgers DR2, Witkamp T2, Zelissen PM3, Meijer FJ4, van Lindert EJ5, Hermus A6, Luijten PR2, Hendrikse J2.
• European radiology.Eur Radiol.2016 Jan;26(1):271-7. doi: 10.1007/s00330-015-3809-x. Epub 2015 May 20.
• OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a
• PMID 25991481

• A role for 11C-methionine PET imaging in ACTH-dependent Cushing's syndrome.

• Koulouri O1, Steuwe A1, Gillett D1, Hoole AC1, Powlson AS1, Donnelly NA1, Burnet NG1, Antoun NM1, Cheow H1, Mannion RJ1, Pickard JD1, Gurnell M2.
• European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2015 Oct;173(4):M107-20. doi: 10.1530/EJE-15-0616. Epub 2015 Aug 5.
• OBJECTIVE: We report our experience of functional imaging with (11)C-methionine positron emission tomography-computed tomography (PET-CT) co-registered with 3D gradient echo (spoiled gradient recalled (SPGR)) magnetic resonance imaging (MRI) in the investigation of ACTH-dependent Cushing's syndrome.
• PMID 26245763

Japanese Journal

• rdwラットの下垂体および副腎機能

• , , [他], , , ,
• Experimental animals 59(1), 95-98, 2010-01-01
• … In the present study, adrenocorticotropic hormone (ACTH) and corticosterone responses to restraint stress (120 min) were examined in rdw adult male rats. … ACTH response to restraint stress was higher in rdw rats than in hetero control rats. … Both ACTH and corticosterone responses to restraint stress in rdw rats recovered to control levels after thyroxine (T4) replacement therapy. …
• NAID 10027852731

• Long-term Remission of Cyclic Cushing's Disease that was Diagnosed and Treated Surgically in Non-active Phase

• , , , , , , , , , , , , ,
• Endocrine Journal 54(3), 407-412, 2007
• … Cyclic Cushing's disease is a rare clinical entity that is defined as a periodic excessive production of adrenocorticotropic hormone (ACTH) and cortisol. … The diagnosis is very difficult because of the fluctuating secretion of ACTH and cortisol. … We report a 78-year-old woman with a pituitary adenoma presenting with cyclic Cushing's disease. …
• NAID 130004770036

• 甲状腺・副腎・性腺の機能的関連性に関する内分泌学的研究

• 藤平 篤志
• The Journal of reproduction and development 50(1), 9-20, 2004-02-01
• 本研究では、甲状腺・副腎・性腺の機能的関連性を明らかにすることを目的として、チオウラシル投与により実験的に甲状腺機能低下症を作出し、甲状腺機能低下時における視床下部・下垂体・副腎軸および視床下部・下垂体・性腺軸の機能について詳細な検討を行った。1.甲状腺と副腎の機能的関連性：甲状腺機能が低下した成熟雄ラットでは、副腎重量が有意に低下し、コルチコステロン分泌反応も対照群に比べて低下したが、ACH、C …
• NAID 10026620695

Related Links

• Pituitary ACTH Hypersecretion - MeSH Result

1: Pituitary ACTH Hypersecretion A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ...

• FAQ • Pituitary Acth Hypersecretion - MEDICAL ...

FAQ • Pituitary Acth Hypersecretion. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided. ... ...

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★リンクテーブル★

リンク元	「下垂体ACTH過剰分泌」
関連記事	「ACT」「AC」「pituitary」「ACTH」「hypersecretion」

「下垂体ACTH過剰分泌」

　　[★]

英

pituitary ACTH hypersecretion

関

クッシング病

「ACT」

　　[★]

• アクチノマイシン actinomycin
• 全血凝固時間 activated clotting time
• 前交連腱 anterior commissure tendon
• 交代遮閉試験 alternate cover test
• α1アンチキモトリプシン, alpha 1-antichymotrypsin, α1-antichymotrypsin

　

「AC」

　　[★]

• アデニル酸シクラーゼ
• 前交連 anterior commissure
• 腹囲 abdominal circumference

「pituitary」

　　[★]

• adj.

• 下垂体の

関

hypophyses、hypophysis、pituitary gland

　 　 　

「ACTH」

　　[★] 副腎皮質刺激ホルモン adrenocorticotropic hormone 　

「hypersecretion」

　　[★]

• 分泌過多、過分泌