WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
any high mountain

PrepTutorEJDIC

American College Testing / Australian Capital Territory
アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
高山,高峰

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/01 20:52:41」(JST)

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Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serpin superfamily.

It inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.^[1]

This protein is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.^[2]

Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.^[1]

Interactions

Alpha 1-antichymotrypsin has been shown to interact with DNAJC1.^[3]

References

^ ^a ^b Kalsheker N (1996). "Alpha 1-antichymotrypsin". Int. J. Biochem. Cell Biol. 28 (9): 961–4. doi:10.1016/1357-2725(96)00032-5. PMID 8930118.
^ "Entrez Gene: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12.
^ Kroczynska, Barbara; Evangelista Christina M, Samant Shalaka S, Elguindi Ebrahim C, Blond Sylvie Y (Mar. 2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. (United States) 279 (12): 11432–43. doi:10.1074/jbc.M310903200. ISSN 0021-9258. PMC 1553221. PMID 14668352. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1553221/.

External links

The MEROPS online database for peptidases and their inhibitors: I04.002
Alpha+1-antichymotrypsin at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on chromosome 14 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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5. α-1アンチトリプシン欠乏症の臨床症状、診断、および自然経過 clinical manifestations diagnosis and natural history of alpha 1 antitrypsin deficiency

English Journal

Hepatic acute phase proteins - Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling.

Bode JG, Albrecht U, Häussinger D, Heinrich PC, Schaper F.SourceDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Medical Faculty, Heinrich-Heine University, Moorenstraße 5, D-40225 Düsseldorf, Germany.
European journal of cell biology.Eur J Cell Biol.2012 Jun;91(6-7):496-505. Epub 2011 Nov 16.
The function of the liver as an important constituent of the immune system involved in innate as well as adaptive immunity is warranted by different highly specialized cell populations. As the major source of acute phase proteins, including secreted pathogen recognition receptors (PRRs), short pentr
PMID 22093287

The development of simple and sensitive small-molecule fluorescent probes for the detection of serum proteins after native polyacrylamide gel electrophoresis.

Wang F, Huang L, Na N, He D, Sun D, Ouyang J.SourceCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
The Analyst.Analyst.2012 May 21;137(10):2367-73. Epub 2012 Apr 5.
In this paper, a simple and sensitive small-molecule fluorescent probe, 2,5-dihydroxy-4'-dimethylaminochalcone (DHDMAC), was designed and synthesized for the detection of human serum proteins via hydrophobic interactions after polyacrylamide gel electrophoresis (PAGE). This probe produced lower fluo
PMID 22475746

Japanese Journal

Histiocytic Sarcoma in the Brain of a Cat

Ide Tetsuya,Uchida Kazuyuki,Tamura Shinji [他],NAKAYAMA Hiroyuki
Journal of Veterinary Medical Science 72(1), 99-102, 2010
… The magnetic resonance image examination revealed a relatively large T1-hypointense and T2-hyperintense mass lesion in the left interventricular foramen region, and there were no abnormalities in the chest and abdominal x-ray radiographic, funduscopic, and electric retinogram findings. …
NAID 130000134507

Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage

SLOWIK A
Stroke 36, 737-740, 2005
NAID 30022681864

Ibuprofen Suppresses Interleukin-1beta Induction of Pro-Amyloidogenic alpha (1)-Antichymotrypsin to Ameliorate beta-Amyloid (Abeta) Pathology in Alzheimer's Models

MORIHARA T
Neuropsychopharmacology 30, 1111-1120, 2005
NAID 30010246071

「ACT」

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
	; PDB rendering based on 1as4.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1AS4, 1QMN, 2ACH, 3CAA, 3DLW, 4CAA
Identifiers
Symbols	SERPINA3; AACT; ACT; GIG25
External IDs	OMIM: 107280 MGI: 105045 HomoloGene: 111129 ChEMBL: 5960 GeneCards: SERPINA3 Gene
Gene Ontology
Molecular function	• DNA binding; • serine-type endopeptidase inhibitor activity; • protein binding;
Cellular component	• extracellular region; • intracellular; • nucleus;
Biological process	• acute-phase response; • inflammatory response; • negative regulation of endopeptidase activity; • regulation of lipid metabolic process; • regulation of proteolysis; • maintenance of gastrointestinal epithelium;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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