α1アンチキモトリプシン、α1-アンチキモトリプシン
WordNet
- first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
- the 1st letter of the Greek alphabet
- the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
- early testing stage of a software or hardware product; "alpha version"
- any high mountain
PrepTutorEJDIC
- American College Testing / Australian Capital Territory
- アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
- 高山,高峰
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/01 20:52:41」(JST)
[Wiki en表示]
| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
PDB rendering based on 1as4. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1AS4, 1QMN, 2ACH, 3CAA, 3DLW, 4CAA
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| Identifiers |
| Symbols |
SERPINA3; AACT; ACT; GIG25 |
| External IDs |
OMIM: 107280 MGI: 105045 HomoloGene: 111129 ChEMBL: 5960 GeneCards: SERPINA3 Gene |
| Gene Ontology |
| Molecular function |
• DNA binding
• serine-type endopeptidase inhibitor activity
• protein binding
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| Cellular component |
• extracellular region
• intracellular
• nucleus
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| Biological process |
• acute-phase response
• inflammatory response
• negative regulation of endopeptidase activity
• regulation of lipid metabolic process
• regulation of proteolysis
• maintenance of gastrointestinal epithelium
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
12 |
20716 |
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| Ensembl |
ENSG00000196136 |
ENSMUSG00000021091 |
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| UniProt |
P01011 |
G3X8T9 |
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| RefSeq (mRNA) |
NM_001085.4 |
NM_009252.2 |
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| RefSeq (protein) |
NP_001076.2 |
NP_033278.2 |
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| Location (UCSC) |
Chr 14:
95.06 – 95.09 Mb |
Chr 12:
104.41 – 104.41 Mb |
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| PubMed search |
[1] |
[2] |
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Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serpin superfamily.
It inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.[1]
This protein is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.[2]
Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.[1]
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Contents
- 1 Interactions
- 2 References
- 3 Further reading
- 4 External links
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Interactions
Alpha 1-antichymotrypsin has been shown to interact with DNAJC1.[3]
References
- ^ a b Kalsheker N (1996). "Alpha 1-antichymotrypsin". Int. J. Biochem. Cell Biol. 28 (9): 961–4. doi:10.1016/1357-2725(96)00032-5. PMID 8930118.
- ^ "Entrez Gene: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12.
- ^ Kroczynska, Barbara; Evangelista Christina M, Samant Shalaka S, Elguindi Ebrahim C, Blond Sylvie Y (Mar. 2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. (United States) 279 (12): 11432–43. doi:10.1074/jbc.M310903200. ISSN 0021-9258. PMC 1553221. PMID 14668352. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1553221/.
Further reading
- Janciauskiene S, Wright HT (1999). "Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.". Bioessays 20 (12): 1039–46. doi:10.1002/(SICI)1521-1878(199812)20:12<1039::AID-BIES10>3.0.CO;2-Z. PMID 10048303.
- Kalsheker N, Morley S, Morgan K (2002). "Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin.". Biochem. Soc. Trans. 30 (2): 93–8. doi:10.1042/BST0300093. PMID 12023832.
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PDB gallery
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1as4: CLEAVED ANTICHYMOTRYPSIN A349R
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1qmn: ALPHA1-ANTICHYMOTRYPSIN SERPIN IN THE DELTA CONFORMATION (PARTIAL LOOP INSERTION)
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2ach: CRYSTAL STRUCTURE OF CLEAVED HUMAN ALPHA1-ANTICHYMOTRYPSIN AT 2.7 ANGSTROMS RESOLUTION AND ITS COMPARISON WITH OTHER SERPINS
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3caa: CLEAVED ANTICHYMOTRYPSIN A347R
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4caa: CLEAVED ANTICHYMOTRYPSIN T345R
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External links
- The MEROPS online database for peptidases and their inhibitors: I04.002
- Alpha+1-antichymotrypsin at the US National Library of Medicine Medical Subject Headings (MeSH)
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Serpins
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| inhibitory |
- Alpha 1-antichymotrypsin
- Alpha 1-antitrypsin
- Alpha 2-antiplasmin
- Antithrombin
- C1-inhibitor
- Heparin cofactor II
- Protein C inhibitor
- Plasminogen activator inhibitor-1
- Plasminogen activator inhibitor-2
- Protein Z-related protease inhibitor
- SERPINA1
- SERPINA2
- SERPINA3
- SERPINA4
- SERPINA5
- SERPINA6
- SERPINA7
- SERPINA8
- SERPINA9
- SERPINA14
- SERPINB1
- SERPINB2
- SERPINB3
- SERPINB4
- SERPINB5
- SERPINB6
- SERPINB7
- SERPINB8
- SERPINB9
- SERPINB13
- SERPINC1
- SERPIND1
- SERPINE1
- SERPINE2
- SERPINE2
- SERPINF1
- SERPING1
- SERPINH1
- SERPINI1
- SERPINI2
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| Cross class inhibitory |
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| noninhibitory |
- Heat shock protein 47
- Maspin
- Ovalbumin
- SERPINF1
- Thyroxine-binding globulin
- Transcortin
- SERPINF1
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see also disorders of globin and globulin proteins
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Proteins: Globular proteins
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| Serum globulins |
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Alpha globulins
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serpins: alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin) · alpha-2 (Alpha 2-antiplasmin) · Antithrombin (Heparin cofactor II)
carrier proteins: alpha-1 (Transcortin) · alpha-2 (Ceruloplasmin) · Retinol binding protein
other: alpha-1 (Orosomucoid) · alpha-2 (alpha-2-Macroglobulin, Haptoglobin)
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Beta globulins
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carrier proteins: Sex hormone-binding globulin · Transferrin
other: Angiostatin · Hemopexin · Beta-2 microglobulin · Factor H · Plasminogen · Properdin
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Gamma globulin
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Immunoglobulins
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Other
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Fibronectin (Fetal fibronectin) · Macroglobulin/Microglobulin · Transcobalamin
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| Other globulins |
Beta-lactoglobulin (Lactoferrin) · Thyroglobulin · Alpha-lactalbumin
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| Albumins |
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Egg white
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Conalbumin · Ovalbumin · Avidin
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Serum albumin
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Human serum albumin · Bovine serum albumin · Prealbumin
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Other
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C-reactive protein · Lactalbumin (Alpha-lactalbumin) · Parvalbumin · Ricin
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see also disorders of globin and globulin proteins
B proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrous
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Protein, glycoconjugate: glycoproteins and glycopeptides
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| Mucoproteins |
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Mucin
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- CD43
- CD164
- MUC1
- MUC2
- MUC3A
- MUC3B
- MUC4
- MUC5AC
- MUC5B
- MUC6
- MUC7
- MUC8
- MUC12
- MUC13
- MUC15
- MUC16
- MUC17
- MUC19
- MUC20
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Other
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- Haptoglobin
- Intrinsic factor
- Orosomucoid
- Peptidoglycan
- Phytohaemagglutinin
- Ovomucin
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| Proteoglycans |
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CS/DS
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- Decorin
- Biglycan
- Versican
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HS/CS
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CS
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- Chondroitin sulfate proteoglycans: Aggrecan
- Neurocan
- Brevican
- CD44
- CSPG4
- CSPG5
- Platelet factor 4
- Structural maintenance of chromosomes 3
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KS
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- Fibromodulin
- Lumican
- Keratocan
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HS
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| Other |
- Activin and inhibin
- ADAM
- Alpha 1-antichymotrypsin
- Apolipoprotein H
- CD70
- Asialoglycoprotein
- Avidin
- B-cell activating factor
- 4-1BB ligand
- Cholesterylester transfer protein
- Clusterin
- Colony-stimulating factor
- Hemopexin
- Lactoferrin
- Membrane glycoproteins
- Myelin protein zero
- Osteonectin
- Protein C
- Protein S
- Serum amyloid P component
- Sialoglycoprotein
- CD43
- Glycophorin
- Glycophorin C
- Thrombopoietin
- Thyroglobulin
- Thyroxine-binding proteins
- Transcortin
- Tumor necrosis factor-alpha
- Uteroglobin
- Vitronectin
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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- biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- amino acids / intermediates
- tetrapyrroles / intermediates
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Acute-phase proteins
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| Amyloid |
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| Other positive |
- Alpha 1-antichymotrypsin
- Alpha 1-antitrypsin
- Alpha 2-macroglobulin
- C-reactive protein
- Ceruloplasmin
- C3
- Ferritin
- Fibrin
- Haptoglobin
- Hemopexin
- Orosomucoid
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| Negative |
- Serum albumin
- Transferrin
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cell/phys/auag/auab/comp, igrc
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UpToDate Contents
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English Journal
- Hepatic acute phase proteins - Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling.
- Bode JG, Albrecht U, Häussinger D, Heinrich PC, Schaper F.SourceDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Medical Faculty, Heinrich-Heine University, Moorenstraße 5, D-40225 Düsseldorf, Germany.
- European journal of cell biology.Eur J Cell Biol.2012 Jun;91(6-7):496-505. Epub 2011 Nov 16.
- The function of the liver as an important constituent of the immune system involved in innate as well as adaptive immunity is warranted by different highly specialized cell populations. As the major source of acute phase proteins, including secreted pathogen recognition receptors (PRRs), short pentr
- PMID 22093287
- The development of simple and sensitive small-molecule fluorescent probes for the detection of serum proteins after native polyacrylamide gel electrophoresis.
- Wang F, Huang L, Na N, He D, Sun D, Ouyang J.SourceCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
- The Analyst.Analyst.2012 May 21;137(10):2367-73. Epub 2012 Apr 5.
- In this paper, a simple and sensitive small-molecule fluorescent probe, 2,5-dihydroxy-4'-dimethylaminochalcone (DHDMAC), was designed and synthesized for the detection of human serum proteins via hydrophobic interactions after polyacrylamide gel electrophoresis (PAGE). This probe produced lower fluo
- PMID 22475746
Japanese Journal
- Histiocytic Sarcoma in the Brain of a Cat
- Ide Tetsuya,Uchida Kazuyuki,Tamura Shinji [他],NAKAYAMA Hiroyuki
- Journal of Veterinary Medical Science 72(1), 99-102, 2010
- … The magnetic resonance image examination revealed a relatively large T1-hypointense and T2-hyperintense mass lesion in the left interventricular foramen region, and there were no abnormalities in the chest and abdominal x-ray radiographic, funduscopic, and electric retinogram findings. …
- NAID 130000134507
- Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage
- Ibuprofen Suppresses Interleukin-1beta Induction of Pro-Amyloidogenic alpha (1)-Antichymotrypsin to Ameliorate beta-Amyloid (Abeta) Pathology in Alzheimer's Models
Related Links
- Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases , such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects ...
- Alpha-1-antichymotrypsin His-Pro-less. Gene names ... Alpha-1-antichymotrypsin can bind DNA. ..... [2], "A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease." ...
Related Pictures
★リンクテーブル★
[★]
[★]
- 英
- alpha 1-antichymotrypsin, α1-antichymotrypsin ACT
- 同
- α1抗キモトリプシン、α1-アンチキモトリプシン
[★]
- 英
- alpha 1-antichymotrypsin
- 関
- α1アンチキモトリプシン
[★]
α、アルファ
- 関
- alfa
[★]