actinomycin

アクチノマイシンDアクチノマイシン  

WordNet

  1. any of various red antibiotics isolated from soil bacteria

PrepTutorEJDIC

  1. American College Testing / Australian Capital Territory

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/05 08:25:37」(JST)

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English Journal

  • Lipopolysaccharide (LPS)-stimulated iNOS Induction Is Increased by Glucosamine under Normal Glucose Conditions but Is Inhibited by Glucosamine under High Glucose Conditions in Macrophage Cells.
  • Hwang JS1, Kwon MY1, Kim KH1, Lee Y2, Lyoo IK2, Kim JE2, Oh ES3, Han IO4.
  • The Journal of biological chemistry.J Biol Chem.2017 Feb 3;292(5):1724-1736. doi: 10.1074/jbc.M116.737940. Epub 2016 Dec 7.
  • We investigated the regulatory effect of glucosamine (GlcN) for the production of nitric oxide (NO) and expression of inducible NO synthase (iNOS) under various glucose conditions in macrophage cells. At normal glucose concentrations, GlcN dose dependently increased LPS-stimulated production of NO/i
  • PMID 27927986
  • Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives.
  • Sidova V1, Zoufaly P1, Pokorny J1, Dzubak P2, Hajduch M2, Popa I1,2, Urban M1,2.
  • PloS one.PLoS One.2017 Feb 3;12(2):e0171621. doi: 10.1371/journal.pone.0171621. eCollection 2017.
  • In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding 30-bromoderivatives, their substitution with sodi
  • PMID 28158265
  • Etoposide, Methotrexate, and Dactinomycin Alternating With Cyclophosphamide and Vincristine (EMACO) for Male Patients With HCG-expressing, Chemoresistant Germ Cell Tumors.
  • Raggi D1, Giannatempo P, Miceli R, Farè E, Piva L, Biasoni D, Catanzaro M, Torelli T, Stagni S, Marongiu M, Gianni AM, Nicolai N, Salvioni R, Necchi A.
  • American journal of clinical oncology.Am J Clin Oncol.2017 Feb;40(1):60-65. doi: 10.1097/COC.0000000000000113.
  • OBJECTIVES: To retrospectively analyze the efficacy and safety results of the combination of methotrexate, dactinomycin, cyclophosphamide, and vincristine (EMACO) regimen for patients with human chorionic gonadotropin (HCG)-producing germ cell tumors and who had failed multiple courses of chemothera
  • PMID 25089532

Japanese Journal

  • 動注化学療法と子宮動脈塞栓術による保存的治療に成功した頸管妊娠の1例
  • 八幡 環,城 道久,八木 重孝 [他],南 佐和子,井箟 一彦
  • 産婦人科の進歩 66(1), 18-23, 2014
  • … を認め当院受診し,経腟超音波検査で頸管内に胎児心拍を伴う胎嚢を認め,MRI所見と合わせて頸管妊娠と診断した.本症例は胎児心拍で,血中hCG値も15000mIU/mlと高値であり,妊孕性温存を希望していたためActinomycin-Dを用いた動注化学療法を選択し,また活動性出血をコントロールする目的で子宮動脈塞栓術を併用した.治療後,子宮頸管からの出血は減少し,第2病日には頸管内の胎嚢は消失した.治療に伴う重篤な有 …
  • NAID 130003391461
  • MEA療法が奏功した難治性非セミノーマ精巣腫瘍の1例
  • 永井 康晴,南 高文,伊丹 祥隆 [他],小林 泰之,清水 信貴,山本 豊,林 泰司,野澤 昌弘,吉村 一宏,石井 徳味,植村 天受
  • 泌尿器科紀要 = Acta urologica Japonica 59(10), 693-697, 2013-10
  • … We experienced a case of testicular cancer that was successfully treated by salvage chemotherapy comprised of methotrexate, actinomycin D and etoposide (MEA). …
  • NAID 120005347148
  • Occurrence and biosynthesis of C-demethylactinomycins in actinomycin-producing Streptomyces chrysomallus and Streptomyces parvulus
  • CRNOVCIC Ivana,VATER Joachim,KELLER Ullrich
  • Journal of antibiotics 66(4), 211-218, 2013-04-25
  • NAID 10031168681

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InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13) 25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21- 31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89 - ...


Related Pictures

Actinomycin D | CAS 50-76-0 - Order from enzymes can beinhibited by actinomycin 체계적 명칭 ( IUPAC 명명법 )Actinomycin D [10mM] - G-Biosciences: API Figure 4 | Actinomycin D Structure of structure of a complex between actinomycin



★リンクテーブル★
リンク元アクチノマイシンD」「ACT」「Cosmegen

アクチノマイシンD」

  [★]

actinomycin D actinomycin-D ACT-D
アクチノマイシン actinomycinダクチノマイシン dactinomycin DACTCosmegen
コスメゲン Cosmegen


  • first aid step1 2006 p.307,309,326

分類

  • 抗生物質

構造

作用機序

  • intercalates in DNA

適応

  • Wilms' tumor, Ewing's sarcoma, rhabdomyosarcoma(first aid step1 2006 p.309) ← 子供の腫瘍

副作用

  • myelosuppression

ACT」

  [★]

 

Cosmegen」

  [★]

コスメゲン

actinomycinactinomycin Ddactinomycin