Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells.
Di Fiore R1, Drago-Ferrante R1, Pentimalli F2, Di Marzo D2, Forte IM2, Carlisi D3, De Blasio A1, Tesoriere G4, Giordano A4, Vento R1,4.
Journal of cellular physiology.J Cell Physiol.2016 Aug;231(8):1832-41. doi: 10.1002/jcp.25291. Epub 2016 Jan 28.
Osteosarcoma (OS), an aggressive highly invasive and metastatic bone-malignancy, shows therapy resistance and recurrence, two features that likely depend on cancer stem cells (CSCs), which hold both self-renewing and malignant potential. So, effective anticancer therapies against OS should specifica
Focal Adhesion Assembly Induces Phenotypic Changes and Dedifferentiation in Chondrocytes.
Shin H1, Lee MN1, Choung JS1, Kim S2, Choi BH3, Noh M4, Shin JH1.
Journal of cellular physiology.J Cell Physiol.2016 Aug;231(8):1822-31. doi: 10.1002/jcp.25290. Epub 2016 Feb 4.
The expansion of autologous chondrocytes in vitro is used to generate sufficient populations for cell-based therapies. However, during monolayer culture, chondrocytes lose inherent characteristics and shift to fibroblast-like cells as passage number increase. Here, we investigated passage-dependent
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