phosphoinositide-dependent kinase 1

PDK1

WordNet

1. relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
2. addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
3. contingent on something else (同)dependant, qualified
4. (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
5. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
6. the basic unit of money in Papua New Guinea

PrepTutorEJDIC

1. 『頼っている』,依存している,従属している / 扶養される人(家族)

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• 1. 黒色腫（メラノーマ）に対する遺伝的感受性 inherited susceptibility to melanoma
• 2. 進行腎細胞癌に対する抗血管新生療法および分子標的療法 anti angiogenic and molecularly targeted therapy for advanced renal cell carcinoma
• 3. 心筋障害のバイオマーカーとしてのトロポニンおよびクレアチンキナーゼ troponins and creatine kinase as biomarkers of cardiac injury
• 4. 前立腺癌の分子生物学 molecular biology of prostate cancer
• 5. 虚血プレコンディショニングの定義および病因 definition and pathogenesis of ischemic preconditioning

English Journal

• Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons.

• Yao Y, Shao C, Jothianandan D, Tcherepanov A, Shouval H, Sacktor TC.SourceDepartment of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, United States.
• Neuropharmacology.Neuropharmacology.2013 Jan;64(1):37-44. doi: 10.1016/j.neuropharm.2012.07.018. Epub 2012 Jul 27.
• PKMζ is an autonomously active, atypical protein kinase C (aPKC) isoform that is both necessary and sufficient for maintaining long-term potentiation (LTP) and long-term memory. The myristoylated ζ-pseudosubstrate peptide, ZIP, potently inhibits PKMζ biochemically in vitro, within cultured cells
• PMID 22846225

• Phosphoinositide-dependent Kinase-1 and Protein Kinase C δ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia.

• Webster BR, Osmond JM, Paredes DA, Deleon XA, Jackson-Weaver O, Walker BR, Kanagy NL.SourceUniversity of New Mexico.
• The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2012 Oct 23. [Epub ahead of print]
• Obstructive sleep apnea (OSA) is associated with cardiovascular complications including hypertension. Previous findings from our laboratory indicate that exposure to intermittent hypoxia (IH), to mimic OSA, increases blood pressure in rats. IH also increases endothelin-1 (ET-1) constrictor sensitivi
• PMID 23093023

Japanese Journal

• Pdk1 Kinase Regulates Basal Disease Resistance Through the OsOxi1-OsPti1a Phosphorylation Cascade in Rice

• MATSUI Hidenori,MIYAO Akio,TAKAHASHI Akira,HIROCHIKA Hirohiko
• Plant and cell physiology 51(12), 2082-2091, 2010-12-01
• NAID 10028056671

• 血管内皮細胞PDK1シグナルの生理的役割の解明 : 血管内皮細胞特異的PDK1欠損マウスを用いた検討

• 俵本 和仁
• 川崎医学会誌 36(4), 301-312, 2010
• NAID 110007990373

Related Links

• Phosphoinositide-dependent kinase-1 - Wikipedia, the free ...

In the field of biochemistry, 3-phosphoinositide dependent protein kinase-1, also known as PDPK1 is a protein which in humans is encoded by the PDPK1 gene. PDPK1 is also known as "PDK1" ("PDK" can be confused with pyruvate ...

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★リンクテーブル★

リンク元	「PDK1」
関連記事	「phosphoinositide」「dependent」「kinase」「dependent kinase」

「PDK1」

　　[★]

英

phosphoinositide-dependent kinase 1

関

PDK, PDK2

• AktのKDドメインのThr残基をリン酸化する (Shiojima et. al.,2008)

「phosphoinositide」

　　[★] ホスホイノシチド

同

phosphoinositides

• ホスホイノシチド、ホスホイノシタイド、イノシトールリン脂質

関

inositol phospholipid、phosphatidyl inositol、phosphatidylinositol、PI、PtdIns

• (イノシトールのリン酸化誘導体を含む脂質)

「dependent」

　　[★]

• adj.

• 依存性の、依存的な、依存型の、依存の

関

depend、dependence、dependency、dependently

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「dependent kinase」

　　[★]

• 依存性キナーゼ、依存性リン酸化酵素